Justification of the renoprotective action of the mixture of sodium chloride and sodium bicarbonate solutions in phenylhydrazine intoxication
DOI:
https://doi.org/10.12775/JEHS.2023.20.01.017Keywords
kidneys, phenylhydrazine, sodium chloride, sodium bicarbonate, renoprotectionAbstract
The authors conducted a study on 35 white Wistar outbred rats to investigate the possibility of correcting acute kidney damage induced by the administration of phenylhydrazine at a dose of 100 mg/kg by introducing a mixture of sodium chloride and sodium bicarbonate solutions into the body.
The research results identified changes in the kidneys upon phenylhydrazine administration, including the loss of some capillary glomeruli, eosinophilic deposits in Bowman's spaces and tubular lumens, and lymphoid infiltration in the interstitium. Rats receiving a mixture of sodium chloride and sodium bicarbonate solutions in their drinking water showed positive changes in their kidneys: no loss of capillary glomeruli was observed, and eosinophilic deposits were absent in most tubules. Lymphocyte aggregation was only observed around some renal vessels. The authors suggest that the intake of additional sodium and bicarbonate into the body, along with alkalinization of the primary urine, promotes the excretion of hemolysis products caused by phenylhydrazine, which contributes to renoprotection and preservation of renal parenchyma.
References
Gozhenko A.I., Dolomatov S.I., Lobanov A.K., Ponomarenko A.N., Karagauskas V.Yu. The influence of rifamycin on the functional state of the kidneys in white rats. Actual Problems of Transport Medicine. – 2005, 9(2). – p. 101-103.
Gozhenko A.I. Pathogenesis of toxic nephropathies. Actual Problems of Transport Medicine. – 2006, No. 4 – p. 25-30.
Kristal N.V., Gozhenko A.I., Sirman V.M. Pathophysiology of the kidney. Kyiv: 2017, 230 p.
Mulay S.R., ShiMax, Anders H.S. Novel insights into Crystalindced kidney injury. Kidney Di. (Basel). 2018; 4(2): 49-57. doi: 10/1159/000487671.
Gozhenko A.I. Energy supply of the main renal functions and processes in normal and kidney damage. Author's abstract for the degree of Doctor of Medical Sciences. Chernivtsi. – 1987. – 39 p.
Vozianov O.F., Gozhenko A.I., Fedoruk O.S. Acute kidney failure. Odesa. – 2003. – 398 p.
Gozhenko A.I. Pathophysiology of the kidneys: from experiment to clinic. Odesa. – 2013. 39 p.
Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. – Official Journal L 276, 20.10.2010. – P. 0033-0079.
Order of the Ministry of Education and Science, Youth and Sports No. 249 of March 1, 2012. – Official Gazette of Ukraine, April 6, 2012. – 2012. – No. 24. – p. 82, article 942. – code of the act 60909/2012.
Gozhenko A.I., Karagauskas V.Yu., Dolomatov S.I. The influence of water and osmotic loads in experimental nephropathy induced by mercury chloride. Nephrology. – 2002. – 6(3). – p. 72-74.
Lucas GNC, Leitao ACC, Alencar R.L., Xaviez RMF, Daher E.F., da Silva Junior G.B. Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs. J. Brasnephral. 2019; 41 (1): 124-130. Doi: 20.1590/2175-8239-JBN-2018-D 109.
Gozhenko A.I. Pathogenesis of toxic nephropathy. Actual Problems of Transport Medicine. 2006, No. 4. – p. 9-15.
Marky K., Spanou L. Acute kidney injury: Definition, Pathophysiology and Clinical Phenotypes. Clin. BioChem. Rev. 2016; 37 (2): 85-98.
Rochal Laurentino M., Castelo L.R., Silva Lee S.A., Cozzi, Bush E.L., Rabb H. Distant Organ Dysfunction in Acute Kidney Injury: A Review Am. J. Kidney Dis. 2018, 72(6): 846-56. doi: 10.1053/j.ajkd. 2018. 03.028/
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