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Journal of Education, Health and Sport

Justification of the renoprotective action of the mixture of sodium chloride and sodium bicarbonate solutions in phenylhydrazine intoxication
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  • Justification of the renoprotective action of the mixture of sodium chloride and sodium bicarbonate solutions in phenylhydrazine intoxication
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  3. Vol. 20 No. 1 (2023) /
  4. Research Articles

Justification of the renoprotective action of the mixture of sodium chloride and sodium bicarbonate solutions in phenylhydrazine intoxication

Authors

  • V. Sirman State Enterprise Ukrainian Research Institute of Transport Medicine Ministry of Health Ukraine, Odesa
  • B. Nasibullin State Institution Ukrainian Research Institute of Medical Rehabilitation and Resort Therapy of Ministry of Health of Ukraine, Odesa https://orcid.org/0000-0003-3963-2374
  • S. Gushcha State Institution Ukrainian Research Institute of Medical Rehabilitation and Resort Therapy of Ministry of Health of Ukraine, Odesa https://orcid.org/0000-0003-3097-5258
  • N. Badyuk State Enterprise Ukrainian Research Institute of Transport Medicine Ministry of Health Ukraine, Odesa https://orcid.org/0000-0002-8290-0605
  • Yu. Dekhtyar Odesa National Medical University, Odesa
  • A. Gozhenko State Enterprise Ukrainian Research Institute of Transport Medicine Ministry of Health Ukraine, Odesa https://orcid.org/0000-0001-7413-4173

DOI:

https://doi.org/10.12775/JEHS.2023.20.01.017

Keywords

kidneys, phenylhydrazine, sodium chloride, sodium bicarbonate, renoprotection

Abstract

The authors conducted a study on 35 white Wistar outbred rats to investigate the possibility of correcting acute kidney damage induced by the administration of phenylhydrazine at a dose of 100 mg/kg by introducing a mixture of sodium chloride and sodium bicarbonate solutions into the body.

The research results identified changes in the kidneys upon phenylhydrazine administration, including the loss of some capillary glomeruli, eosinophilic deposits in Bowman's spaces and tubular lumens, and lymphoid infiltration in the interstitium. Rats receiving a mixture of sodium chloride and sodium bicarbonate solutions in their drinking water showed positive changes in their kidneys: no loss of capillary glomeruli was observed, and eosinophilic deposits were absent in most tubules. Lymphocyte aggregation was only observed around some renal vessels. The authors suggest that the intake of additional sodium and bicarbonate into the body, along with alkalinization of the primary urine, promotes the excretion of hemolysis products caused by phenylhydrazine, which contributes to renoprotection and preservation of renal parenchyma.

References

Gozhenko A.I., Dolomatov S.I., Lobanov A.K., Ponomarenko A.N., Karagauskas V.Yu. The influence of rifamycin on the functional state of the kidneys in white rats. Actual Problems of Transport Medicine. – 2005, 9(2). – p. 101-103.

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Order of the Ministry of Education and Science, Youth and Sports No. 249 of March 1, 2012. – Official Gazette of Ukraine, April 6, 2012. – 2012. – No. 24. – p. 82, article 942. – code of the act 60909/2012.

Gozhenko A.I., Karagauskas V.Yu., Dolomatov S.I. The influence of water and osmotic loads in experimental nephropathy induced by mercury chloride. Nephrology. – 2002. – 6(3). – p. 72-74.

Lucas GNC, Leitao ACC, Alencar R.L., Xaviez RMF, Daher E.F., da Silva Junior G.B. Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs. J. Brasnephral. 2019; 41 (1): 124-130. Doi: 20.1590/2175-8239-JBN-2018-D 109.

Gozhenko A.I. Pathogenesis of toxic nephropathy. Actual Problems of Transport Medicine. 2006, No. 4. – p. 9-15.

Marky K., Spanou L. Acute kidney injury: Definition, Pathophysiology and Clinical Phenotypes. Clin. BioChem. Rev. 2016; 37 (2): 85-98.

Rochal Laurentino M., Castelo L.R., Silva Lee S.A., Cozzi, Bush E.L., Rabb H. Distant Organ Dysfunction in Acute Kidney Injury: A Review Am. J. Kidney Dis. 2018, 72(6): 846-56. doi: 10.1053/j.ajkd. 2018. 03.028/

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Published

2023-09-29

How to Cite

1.
SIRMAN, V., NASIBULLIN, B., GUSHCHA, S., BADYUK, N., DEKHTYAR, Yu. and GOZHENKO, A. Justification of the renoprotective action of the mixture of sodium chloride and sodium bicarbonate solutions in phenylhydrazine intoxication. Journal of Education, Health and Sport. Online. 29 September 2023. Vol. 20, no. 1, pp. 189-203. [Accessed 7 July 2025]. DOI 10.12775/JEHS.2023.20.01.017.
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Issue

Vol. 20 No. 1 (2023)

Section

Research Articles

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Copyright (c) 2023 V. Sirman, B. Nasibullin, S. Gushcha, N. Badyuk, Yu. Dekhtyar, A. Gozhenko

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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