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Journal of Education, Health and Sport

The impact of L-Arginine supplementation on disorders associated with obesity
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The impact of L-Arginine supplementation on disorders associated with obesity

Authors

  • Justyna Żyga Wojewódzki Szpital Specjalistyczny: Lublin https://orcid.org/0000-0001-5453-1235

DOI:

https://doi.org/10.12775/JEHS.2022.12.09.027

Keywords

L-arginine, cardiovascular disease, metabolic disorder, insulin resistance, obesity

Abstract

Introduction: L-Arginine (2-amino-5-guanidinovaleric acid) is a conditionally essential amino acid and a natural constituent of dietary proteins, serving as a precursor for the synthesis not only of proteins, urea, polyamines, proline, glutamate and creatine. This amino acid is a substrate for nitric oxide production, an endogenous messenger molecule involved in a variety of endothelium mediated physiological effects in the vascular system. 

State of knowledge: The evidence suggests supplementation of L-Arginine may have a positive impact in conditions associated with obesity - type 2 diabetes, atherosclerosis or hypercholesterolaemia. The L-Arginine intake improves insulin sensitivity and may improve lipid profile reducing triglyceride serum levels. As a precursor for nitric oxide synthesis, a molecule involved in a variety of physiological effects in the vascular system, L-Arginine can have a positive impact on the cardiovascular system.

Conclusions: The evidence suggests that the L-Arginine may improve lipid profile reducing triglyceride serum levels. L-Arginine could be used as a strategy to improve endothelial function in the selected group of patients. Careful studies are necessary to assess its safety profile, determine under which conditions L-Arginine supplementation is appropriate and when it is undesirable. Attention should be focused to markers of oxidative stress and blood pressure stability.

References

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Jobgen W, Meininger CJ, Jobgen SC, et al. Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats. J Nutr. 2009;139(2):230-237;

Suliburska, J, Bogdanski, P, Szulinska, M. et al. Changes in mineral status are associated with improvements in insulin sensitivity in obese patients following L-arginine supplementation. Eur J Nutr 53, 387–393 (2014);

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Published

2022-08-31

How to Cite

1.
ŻYGA, Justyna. The impact of L-Arginine supplementation on disorders associated with obesity. Journal of Education, Health and Sport. Online. 31 August 2022. Vol. 12, no. 9, pp. 223-228. [Accessed 16 May 2025]. DOI 10.12775/JEHS.2022.12.09.027.
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Issue

Vol. 12 No. 9 (2022)

Section

Review Articles

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Copyright (c) 2022 Justyna Żyga

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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