The influence of sleep disturbances on the development of insulin resistance - a literature review
Keywordssleep, insulin resistance, sleep deprivation
Introduction and purpose of the work: Sleep is essential for the proper functioning of the body. Adequate quality and quantity of sleep affects metabolic processes, including glucose metabolism, as well as the sensitivity of tissues to insulin, the reduction of which is called insulin resistance. It leads to an increased production of glucose in order to maintain normal blood glucose levels. Insulin resistance is a modifiable risk factor of, inter alia, type 2 diabetes. The aim of this study is to summarize the current knowledge on the relationship between sleep deprivation and an increased risk of developing insulin resistance.
State of knowledge: Sleep undoubtedly has a strong influence on glucose metabolism and insulin sensitivity. Numerous studies show that even partial sleep deprivation lowers insulin sensitivity. The available literature shows that shift work and a shifted bedtime, combined with an insufficient amount of it, lead to a significant reduction in insulin sensitivity. The positive effect of increasing the time of night rest on the sensitivity of tissues to insulin may be an element of the prevention of diseases such as obesity or type 2 diabetes. Moreover, disturbances in sleep continuity lead to formation of insulin resistance. An example would be obstructive sleep apnea, the treatment of which affects metabolic processes.
Summary: Adequate sleep hygiene is an extremely important part of a healthy lifestyle. More research is needed on the relationship between sleep and the regulation of carbohydrate metabolism, due to the fact that the appropriate sleep-wake rhythm may give hope for improvement in health in people with metabolic disorders and may be an important protective factor for many diseases.
Vgontzas, A., Fernandez-Mendoza, J., Miksiewicz, T. et al. Unveiling the longitudinal association between short sleep duration and the incidence of obesity: the Penn State Cohort. Int J Obes 38, 825–832 (2014). https://doi.org/10.1038/ijo.2013.172
Stenvers DJ, Scheer FAJL, Schrauwen P, la Fleur SE, Kalsbeek A. Circadian clocks and insulin resistance. Nat Rev Endocrinol. 2019 Feb;15(2):75-89. doi: 10.1038/s41574-018-0122-1. PMID: 30531917.
Pizinger T, Kovtun K, RoyChoudhury A, Laferrère B, Shechter A, St-Onge MP. Pilot study of sleep and meal timing effects, independent of sleep duration and food intake, on insulin sensitivity in healthy individuals. Sleep Health. 2018 Feb;4(1):33-39. doi: 10.1016/j.sleh.2017.10.005. Epub 2017 Nov 20. PMID: 29332677; PMCID: PMC5771427.
Buxton OM, Pavlova M, Reid EW, Wang W, Simonson DC, Adler GK. Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes. 2010 Sep;59(9):2126-33. doi: 10.2337/db09-0699. Epub 2010 Jun 28. PMID: 20585000; PMCID: PMC2927933.
Khalyfa A, Gozal D, Masa JF, Marin JM, Qiao Z, Corral J, González M, Marti S, Kheirandish-Gozal L, Egea C, Sánchez-Quiroga MÁ, de Terreros FJG, Barca FJ. Sleep-disordered breathing, circulating exosomes, and insulin sensitivity in adipocytes. Int J Obes (Lond). 2018 Jun;42(6):1127-1139. doi: 10.1038/s41366-018-0099-9. Epub 2018 Jun 11. PMID: 29892042; PMCID: PMC6195831.
Broussard JL, Ehrmann DA, Van Cauter E, Tasali E, Brady MJ. Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study. Ann Intern Med. 2012 Oct 16;157(8):549-57. doi: 10.7326/0003-4819-157-8-201210160-00005. PMID: 23070488; PMCID: PMC4435718.
Ciaran J. McMullan, Gary C. Curhan, Eva S. Schernhammer, John P. Forman, Association of Nocturnal Melatonin Secretion With Insulin Resistance in Nondiabetic Young Women, American Journal of Epidemiology, Volume 178, Issue 2, 15 July 2013, Pages 231–238, https://doi.org/10.1093/aje/kws470
Rachel Leproult, PhD, Gaétane Deliens, PhD, Médhi Gilson, MS, Philippe Peigneux, PhD, Beneficial Impact of Sleep Extension on Fasting Insulin Sensitivity in Adults with Habitual Sleep Restriction, Sleep, Volume 38, Issue 5, 1 May 2015, Pages 707–715, https://doi.org/10.5665/sleep.4660
Rachel Leproult, Ulf Holmbäck, Eve Van Cauter; Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss. Diabetes 1 June 2014; 63 (6): 1860–1869. https://doi.org/10.2337/db13-1546
Cedernaes J, Lampola L, Axelsson EK, Liethof L, Hassanzadeh S, Yeganeh A, Broman JE, Schiöth HB, Benedict C. A single night of partial sleep loss impairs fasting insulin sensitivity but does not affect cephalic phase insulin release in young men. J Sleep Res. 2016 Feb;25(1):5-10. doi: 10.1111/jsr.12340. PMID: 26361380.
Reutrakul S, Van Cauter E. Sleep influences on obesity, insulin resistance, and risk of type 2 diabetes. Metabolism. 2018 Jul;84:56-66. doi: 10.1016/j.metabol.2018.02.010. Epub 2018 Mar 3. PMID: 29510179.
National Sleep Foundation. Sleep in America poll. Available from https://sleepfoundation.org/sleep-polls-data/sleep-in-america-poll/2009-health-andsafety; 2009, Accessed date: 30 June 2017.
Cappuccio FP, Taggart FM, Kandala NB, Currie A, Peile E, Stranges S, et al. Metaanalysis of short sleep duration and obesity in children and adults. Sleep 2008;31 (5):619–26.
Anothaisintawee T, Reutrakul S, Van Cauter E, Thakkinstian A. Sleep disturbances compared to traditional risk factors for diabetes development: systematic review and meta-analysis. Sleep Med Rev 2015;30:11–24.
How to Cite
Copyright (c) 2022 Katarzyna Skowrońska, Anna Chmura, Patrycja Baciur, Anna Karaś, Filip Białas
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Number of views and downloads: 138
Number of citations: 0