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Journal of Education, Health and Sport

GLP-1 analogs in the treatment of obesity
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GLP-1 analogs in the treatment of obesity

Authors

  • Aleksandra Metelska Wojewódzki Szpital Specjalistyczny im. Stefana Kardynała Wyszyńskiego, al. Kraśnicka 100 w Lublinie https://orcid.org/0000-0002-3166-1296
  • Jakub Metelski Provincial Specialist Hospital of the name Stefan Cardinal Wyszyński, Aleja Kraśnicka 100, 20-718 Lublin https://orcid.org/0000-0002-7110-9332
  • Dominika Sereda Independent Public Clinical Hospital No. 4 in Lublin, Jaczewskiego 8, 20-954 Lublin https://orcid.org/0000-0003-4189-1674
  • Hubert Nieścior Medical University of Lublin, Aleje Racławickie 1, 20-059 Lublin https://orcid.org/0000-0002-4709-4396

DOI:

https://doi.org/10.12775/JEHS.2022.12.08.034

Keywords

glucagon-like peptide-1, obesity, GLP-1 receptor expression, GLP-1R driven food-oriented behaviors

Abstract

Introduction and purpose

Obesity is a chronic disease that causes the development of numerous complications such as cardiovascular disease, cancer and type 2 diabetes. The 2017 global nutrition report showed that 2 billion adults and 41 million children worldwide are overweight or obese. Due to the growing problem of obesity, pharmacotherapy is recommended in patients with BMI ≥30 kg / m2 or BMI> 27 kg / m2 with accompanying risk factors. The aim of the study is to discuss the role of GLP-1 analogues in the treatment of obesity.

Description of the state of knowledge 

GLP-1 receptor agonists that were initially related to the treatment of type 2 diabetes are now being used successfully in the treatment of obesity.

The GLP-1 hormone is released from intestinal enteroendocrine cells in response to an increase in glucose levels. Due to the wide neuroanatomical distribution of GLP-1R within the structures of the reward system, it is possible to suppress the need for food intake, which translates into a reduction in the amount of food consumed and a decrease in body weight. The most common side effects associated with the use of GLP-1 analogues include gastrointestinal symptoms such as nausea, vomiting, diarrhea and constipation, which rarely lead to discontinuation of treatment.

Summary

Numerous studies have shown that chronic systemic delivery of GLP-1 agonists led to weight loss and helped to maintain a lower body weight. Reduction in food intake is reported as the main mechanism. Discontinuation of the drug was associated with weight gain.

References

Rynkowska S, Tąpolska M, Owecki M, Epidemiology of obesity in Poland and in the world, Postępy Biologii Komórki Tom 46 2019 NR 3 (235–242). Polish.

Apovian CM. Obesity: definition, comorbidities, causes, and burden. Am J Manag Care. 2016 Jun;22(7 Suppl):s176-85. PMID: 27356115.

Ross R, Neeland IJ, Yamashita S, Shai I, Seidell J, Magni P, Santos RD, Arsenault B, Cuevas A, Hu FB, Griffin BA, Zambon A, Barter P, Fruchart JC, Eckel RH, Matsuzawa Y, Després JP. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity. Nat Rev Endocrinol. 2020 Mar;16(3):177-189. doi: 10.1038/s41574-019-0310-7. Epub 2020 Feb 4. PMID: 32020062; PMCID: PMC7027970.

Endalifer ML, Diress G. Epidemiology, Predisposing Factors, Biomarkers, and Prevention Mechanism of Obesity: A Systematic Review. J Obes. 2020 May 31;2020:6134362. doi: 10.1155/2020/6134362. PMID: 32566274; PMCID: PMC7281819.

Grill HJ. A Role for GLP-1 in Treating Hyperphagia and Obesity. Endocrinology. 2020 Aug 1;161(8):bqaa093. doi: 10.1210/endocr/bqaa093. PMID: 32516384; PMCID: PMC7899438.

Ruban A, Stoenchev K, Ashrafian H, Teare J. Current treatments for obesity. Clin Med (Lond). 2019 May;19(3):205-212. doi: 10.7861/clinmedicine.19-3-205. PMID: 31092512; PMCID: PMC6542229.

Müller TD, Finan B, Bloom SR, D'Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschöp MH. Glucagon-like peptide 1 (GLP-1). Mol Metab. 2019 Dec;30:72-130. doi: 10.1016/j.molmet.2019.09.010. Epub 2019 Sep 30. PMID: 31767182; PMCID: PMC6812410.

Skibicka KP. The central GLP-1: implications for food and drug reward. Front Neurosci. 2013 Oct 14;7:181. doi: 10.3389/fnins.2013.00181. PMID: 24133407; PMCID: PMC3796262.

Kadouh H, Chedid V, Halawi H, Burton DD, Clark MM, Khemani D, Vella A, Acosta A, Camilleri M. GLP-1 Analog Modulates Appetite, Taste Preference, Gut Hormones, and Regional Body Fat Stores in Adults with Obesity. J Clin Endocrinol Metab. 2020 May 1;105(5):1552–63. doi: 10.1210/clinem/dgz140. PMID: 31665455; PMCID: PMC7105351.

Wharton S, Davies M, Dicker D, Lingvay I, Mosenzon O, Rubino DM, Pedersen SD. Managing the gastrointestinal side effects of GLP-1 receptor agonists in obesity: recommendations for clinical practice. Postgrad Med. 2022 Jan;134(1):14-19. doi: 10.1080/00325481.2021.2002616. Epub 2021 Nov 29. PMID: 34775881.

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Published

2022-08-06

How to Cite

1.
METELSKA, Aleksandra, METELSKI, Jakub, SEREDA, Dominika and NIEŚCIOR, Hubert. GLP-1 analogs in the treatment of obesity. Journal of Education, Health and Sport. Online. 6 August 2022. Vol. 12, no. 8, pp. 334-342. [Accessed 21 May 2025]. DOI 10.12775/JEHS.2022.12.08.034.
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Issue

Vol. 12 No. 8 (2022)

Section

Review Articles

License

Copyright (c) 2022 Aleksandra Metelska, Jakub Metelski, Dominika Sereda, Hubert Nieścior

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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