Features of the reaction of the kidney function of healthy rats to the intake of boric hydrocarbonate sodium mineral waters of varying quantitative macro- and micro-composition
DOI:
https://doi.org/10.12775/JEHS.2022.12.06.035Keywords
boron-containing mineral waters, renal parenchyma, diuresis, excretory function, osmolarityAbstract
The purpose of the work is a comparative assessment of the effect of boron hydrocarbonate sodium mineral waters with a varying quantitative and qualitative composition of macroelements and with different amounts of a bioactive element on the state of the urinary system of rats. Materials and methods. The work was performed on 81 white rats of the Wistar line of auto bred breeding, weighing 180-200 g. The rats were divided into four groups: group 1 - 21 intact rats served as controls; group 2 - 20 rats treated intragastrically with a soft probe MW "Polyana Ploskivskaya" at a dose of 1% of body weight daily, a course of 7 days; group 3 - 20 rats treated with MW "Polyana Kupel" according to the above method; group 4 - 20 rats treated with MW "Svalyava" according to the above process. Before removing the animals from the experiment, daily urine was collected from them; blood was also taken from the tail vein for biochemical studies. At autopsy, pieces of kidneys were taken for histological and histoenzymological studies (the activity of succinate dehydrogenase and lactate dehydrogenase was determined). Results. The histological studies showed no pathological changes in the kidneys were observed with the use of the studied boron MW. Still, there were structural changes, as well as an increase in the activity of redox enzymes. Changes in kidney function were unidirectional with using any of the investigated MW. Still, they had quantitative differences, which are less related to the amount of boron (in the form of orthoboric acid) in 1 liter of MW and more dependent on the osmolarity of the MW, the qualitative composition of macronutrients, and their ratio. Conclusion. We believe that osmolarity, as an integrated indicator of the state of the macronutrient component of MW, can be used to assess its effect on the structural and functional characteristics of the kidneys.
References
Nocco PB. Mineral wasser als Heilmittel [Mineral water as a cure]. Veroff Schweiz Ges Gesch Pharm. 2008;29:13-402. German. https://pubmed.ncbi.nlm.nih.gov/19230311/.
Dragomiretska NV, Babov KD, Gushcha SG, Zabolotna IB, Plakida AL, Izha AN, Nasibullin BA. Application of mineral waters in the complex treatment of patients with gastroesophageal reflux diseasе. Minerva Gastroenterologica e Dietologica. 2020.Mar 24;66(3):225–237. DOI: 10.23736/s1121-421x.20.02601-x.
Gushcha SG, Dragomiretska NV, Zabolotna IB, Nasibullin BA, Izha AN, Вadiuk NS, Koieva KA. Possibilities of using natural mineral waters in the treatment of patients with non-alcoholic fatty liver disease. Balneo Research Journal. 2019;10(4):450–456. DOI: 10.12680/balneo.2019.280.
Babov КD, Nikipelova ОМ, Sydorenko OS, Gushcha SG, Zabolotna IВ, Zukow W. Grounds for the establishment of a state-owned resort on the territory of the city of Morshyn, Lviv region, Ukraine. Ecological Questions. 2021;32(1). DOI: http://dx.doi.org/10.12775/EQ.2021.005.
Zolotareva TA, Babov KD, Nasibullin BA, Kozjavkin VI, Torohtin AM, Jushkovskaja OG. Medical rehabilitation. 2012. Kyiv:KІM. 496 р.
Gálvez I, Torres-Piles S, Ortega-Rincón E. Balneotherapy, Immune System, and Stress Response: A Hormetic Strategy? Int J Mol Sci. 2018;19(6):1687. DOI: 10.3390 / ijms19061687.
Bilas VR, Popadynets’ OO, Flyunt IS, Chebanenko N, Badiuk NS, Gushcha SG, Zukow W, Popovych IL. Entropies of thymocytogram, splenocytogram, immunocytogram and leukocytogram in rats are regulated by sex and the neuroendocrine parameters while regulates immune parameters. Journal of Education, Health and Sport. 2020;10(7):266-288. https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.07.031.
Kysylevska A, Babov K, Gushcha S, Prokopovich I, Nasibullin B. Using the Specific Molarity Indicator of the Chemical Parameters of Mineral Waters in Assessing Their Biological Effects. In: Tonkonogyi V. et al. (eds) Advanced Manufacturing Processes II. Inter Partner 2021. Lecture Notes in Mechanical Engineering. Springer, Cham: 823–832. DOI: 10.1007/978-3-030-68014-5_80.
Babov КD, Bezverkhniuk ТN, Gushcha SG, Zabolotna IB, Kysylevska AYu. Koeva KA, Pogrebnyi AL, Tsurkan OI. Natural healing resources: the alphabet of the user: information and analytical guide. State Institution «Ukrainian Research Institute of Medical Rehabilitation and Resort Therapy of the Ministryof Health of Ukraine». «Poligraf»: Оdessа, 2021. 76 p.
Directive 2009/54/EC of the European Parliament and of the Council of 18 June 2009 on the exploitation and marketing of natural mineral waters. https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32009L0054&from=PL.
Pogorelov M.V., Bumeister V.I., Tkach G.F., etc. Macro- and microelements (exchange, pathology and methods of determination): monograph. Sumy: Publishing House of Sumy State University, 2010;147 p.
Avtsyn A.P., Zhavoronkov A.A., Rish M.A., Strochkova L.S. Human microelementoses: etiology, classification, organopathology. M.: Medicine, 1991. – 496 p.https://www.twirpx.com/file/112144/.
Prashanth L, Kattapagari KK, Chitturi RT, BaddamVR, PrasadLK. A review on role of essential trace elements in health and disease. J NTR Univ Health Sci 2015;4:75-85. DOI: 10.4103/2277-8632.158577.
Semchyshyn MG, Zadorozhna BV, Shevaga VM, Zadorozhnyi AM. Functional value and modern view on the role of trace elementsin neurology (review of literature). Buk. Med. Herald. 2017;21(1):215-220. DOI: https://doi.org/10.24061/2413-0737.XXI.1.81.2017.46.
Shenkin A. Micronutrients in health and disease. Postgrad Med J. 2006;82(971):559-567. DOI:10.1136/pgmj.2006.047670.
Pizzorno L. Nothing Boring About Boron. Integr Med (Encinitas). 2015;14(4):35-48. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/.
Bakidere S, ÖrneyS, Kormaz M. Effect of Boronon Human Health. The open mineral processimg jornal. 2010;3(1):54-59. DOI: 10.2174/1874814010030010054.
Various hydrochemicaland biological features of boric mineral waters in Ukraine Nikipelova ОМ, Nasibullin BА, Gushcha SG, Solodova LB. In: Medico-hydrogeochemical factors of the geological environment of Ukraine / ed. GI. Rudkо. Kyiv. Chernivtsi: Bukrek, 2015:346–381. https://core.ac.uk/download/pdf/132578227.pdf.
Nielsen CH. Update on human health effect of boron- J. Trance Elem Med. Biol. 2014 Оct; 28(4):383-387. DOI: 10.1016/.
Gushcha SG, Nasibullin BA, Рlakida АL, Volyanska VS, Gladkіy TV, Balashova IV. Hepatoprotective Action of Boric Mineral Waters in Toxic Hepatosis: Experimental Study. Open Science Journal of Bioscience and Bioengineering. 2018;6(5):55-60. http://www.openscienceonline.com/journal/archive2?journalId=738&paperId=4832.
Quattrini S, Pampaloni B, Brandi ML. Natural mineral waters: chemical characteristics and health effects. Clin Cases Miner Bone Metab. 2016;13(3):173- 180. DOI:10.11138/ccmbm/2016.13.3.173.
Crespo PV, Campos F, Leal M, Maraver F. Effects of Sodium Chloride-Rich Mineral Water on Intestinal Epithelium. Experimental Study. Int J Environ Res Public Health. 2021. Mar 22;18(6):3261. DOI: 10.3390/ijerph18063261.
Council Directive 2010/63/EU of 22 September 2010 on the protection of animals used for scientific purposes. Official Journal of the European Communities, 2010;276:33-79. https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2010:276:0033:0079:EN:PDF
Order Ministry of education and science, youth and sports of Ukraine from 01.03.2012 № 249. Official gazette of Ukraine from 2012;24:82. https://zakon.rada.gov.ua/laws/show/z0416-12#Text.
Gushcha SG, Nasibullin BA, Koeva KА, Аrabadji МV, Badiuk NS, Kysylevska AYu. Long-term studies of the chemical composition and biological activity of silt-sulfide peloids of the Kuyalnitsky estuary. PhOL – PharmacologyOnLine. 2021;2:753-760. https://pharmacologyonline.silae.it/front/archives_2021_2.
Lojda Z, Grossrau R, Schiebler TN. Enzyme Histochemistry. A Laboratory Manual. Springer-Verlag Berlin-Heidelberg New York 1979.
On approval of the recommendations of the research methods of biological effects of natural medical resources and preformed medicines: of Ministry of Health of Ukraine № 692, from 28.09.09. Kiev: 2009. http://old.moz.gov.ua/ua/portal/dn_20090928_692.html.
Mineral healing waters. Specifications: Industry Standard of Ukraine 42.10-02-96. Kiev: Ministry of Health, 1996. 30 p.
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