Metabolic accompaniment of urina lithogenicity in female rats
Keywordsurine lithogenicity, plasma metabolites, drinking mineral waters, Truskavets’ spa, female rats
Background. We have previously discovered connections between the lithogenicity index of urine and a number of components of its composition. The aim of this study is to determine the relationship between the urine lithogenicity index and a number of metabolic components of plasma. Materials and Methods. Experiment was performed on 60 healthy old female Wistar rats 220-300 g. Ten animals remained intact, using daily water from drinking ad libitum. Other animals for 6 days were loaded through the tube with daily and various mineral waters at a dose of 1,5 mL/100 g of body mass. The day after the completion of the drinking course collected daily urine and estimate its lithogenicity. We determined plasma levels of electrolytes, nitric metabolites, glucose, amylase, cholesterol and lipids peroxidation parameters. Results. The lithogenicity of urine is upregulated by the plasma level of uric acid, bilirubin, potassium, malondialdehyde and catalase, but it is downregulated by calciumemia. The rate of determination of lithogenicity is 45,7%. Conclusion. Both lithogenic and litholytic factors are present in the plasma. This gives grounds for finding ways to correct lithogenicity.
Andreyeva LI, Kozhemyakin LA, Kishkun AA. Modification of the method for determining the lipid peroxide in the test with thiobarbituric acid [in Russian]. Laboratornoye Delo. 1988; 11: 41-43.
Dubinina YY, Yefimova LF, Sofronova LN, Geronimus AL. Comparative analysis of the activity of superoxide dismutase and catalase of erythrocytes and whole blood from newborn children with chronic hypoxia [in Russian]. Laboratornoye Delo. 1988; 8: 16-19.
Fedoruk AS, Gozhenko AI, Rohovyi YY. Protective effect of α-tocopherol on kidney function and lipid peroxidation in acute hemic hypoxia [in Russian]. Patologicheskaya Fiziologiya. 1998; 4: 35-38.
Flyunt VR, Flyunt I-SS, Ruzhylo SV, Fihura OA, Popovych DV, Źukow X. Relationships of urolithogenicity index with some components of urine composition in healthy old female rats. Journal of Education, Health and Sport. 2021; 11(10): 357-372.
Gavrilov VB, Mishkorudnaya MI. Spectrophotometric determination of plasma levels of lipid hydroperoxides [in Russian]. Laboratornoye Delo. 1983; 3: 33-36.
Goryachkovskiy АМ. Clinical Biochemistry [in Russian]. Odesa. Astroprint; 1998: 608.
Gozhenko AI, Fedoruk AS, Kotyuzhinskaya SG. Changes in kidney function during acute intoxication with sodium nitrite in an experiment [in Russian]. Patologicheskaya Fiziologiya. 2003; 1: 28-30.
Hrytsan II, Gozhenko AI, Badiuk NS, Zukow W. Variants of the state of electrolyte exchange in female rates. Journal of Education, Health and Sport. 2019; 9(10): 262-279.
Klecka WR. Discriminant Analysis [trans. from English in Russian] (Seventh Printing, 1986). In: Factor, Discriminant and Cluster Analysis. Moskva: Finansy i Statistika; 1989: 78-138.
Korolyuk MA, Ivanova MI, Mayorova IG, Tokarev VYe. The method for determining the activity of catalase [in Russian]. Laboratornoye Delo. 1988; 1: 16-19.
Makarenko YeV. A comprehensive definition of the activity of superoxide dismutase and glutathione reductase in red blood cells in patients with chronic liver disease [in Russian]. Laboratornoye Delo. 1988; 11: 48-50.
How to Cite
Copyright (c) 2022 Viktor Flyunt, Igor-Severyn Flyunt, Xawery Żukow
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Number of views and downloads: 70
Number of citations: 0