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Journal of Education, Health and Sport

Metabolic accompaniment of urina lithogenicity in female rats
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Metabolic accompaniment of urina lithogenicity in female rats

Authors

  • Viktor Flyunt SE Ukrainian Research Institute of Medicine of Transport, Odesa; JSC “Dnipro-Beskyd”, Truskavets’
  • Igor-Severyn Flyunt Ivan Franko State Pedagogical University, Drohobych
  • Xawery Żukow Medical University of Bialystok, Bialystok https://orcid.org/0000-0001-5028-7829

DOI:

https://doi.org/10.12775/JEHS.2022.12.05.027

Keywords

urine lithogenicity, plasma metabolites, drinking mineral waters, Truskavets’ spa, female rats

Abstract

Background. We have previously discovered connections between the lithogenicity index of urine and a number of components of its composition. The aim of this study is to determine the relationship between the urine lithogenicity index and a number of metabolic components of plasma. Materials and Methods. Experiment was performed on 60 healthy old female Wistar rats 220-300 g. Ten animals remained intact, using daily water from drinking ad libitum. Other animals for 6 days were loaded through the tube with daily and various mineral waters at a dose of 1,5 mL/100 g of body mass. The day after the completion of the drinking course collected daily urine and estimate its lithogenicity. We determined plasma levels of electrolytes, nitric metabolites, glucose, amylase, cholesterol and lipids peroxidation parameters. Results. The lithogenicity of urine is upregulated by the plasma level of uric acid, bilirubin, potassium, malondialdehyde and catalase, but it is downregulated by calciumemia. The rate of determination of lithogenicity is 45,7%. Conclusion. Both lithogenic and litholytic factors are present in the plasma. This gives grounds for finding ways to correct lithogenicity.

References

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Flyunt VR, Flyunt I-SS, Ruzhylo SV, Fihura OA, Popovych DV, Źukow X. Relationships of urolithogenicity index with some components of urine composition in healthy old female rats. Journal of Education, Health and Sport. 2021; 11(10): 357-372.

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Published

2022-05-31

How to Cite

1.
FLYUNT, Viktor, FLYUNT, Igor-Severyn & ŻUKOW, Xawery. Metabolic accompaniment of urina lithogenicity in female rats. Journal of Education, Health and Sport [online]. 31 May 2022, T. 12, nr 5, s. 342–351. [accessed 30.3.2023]. DOI 10.12775/JEHS.2022.12.05.027.
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Issue

Vol. 12 No. 5 (2022)

Section

Research Articles

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Copyright (c) 2022 Viktor Flyunt, Igor-Severyn Flyunt, Xawery Żukow

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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