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Journal of Education, Health and Sport

Glomerular filtration and diuresis are related to the state of lipids peroxidation in female rats exposed to water-salt loads accompanied by chronic stress
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  • Glomerular filtration and diuresis are related to the state of lipids peroxidation in female rats exposed to water-salt loads accompanied by chronic stress
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  3. Vol. 11 No. 12 (2021) /
  4. Research Articles

Glomerular filtration and diuresis are related to the state of lipids peroxidation in female rats exposed to water-salt loads accompanied by chronic stress

Authors

  • Xawery Żukow Medical University of Bialystok, Bialystok https://orcid.org/0000-0001-5028-7829
  • Yuriy Zavidnyuk IY Horbachevs’kyi National Medical University, Ternopil’ https://orcid.org/0000-0002-4028-0743

DOI:

https://doi.org/10.12775/JEHS.2021.11.12.039

Keywords

glomerular filtration, diuresis, lipid peroxidation, relationships, water-salt loads, chronic stress, rats

Abstract

Background. It is known about the existence of close functional link between adequate working kidney nephrons and bone metabolism. Focused monitoring of renal function is able to provide substantial assistance in the organization of preventive measures against latently emerging osteoporosis. Activation of lipoperoxidation is known to inhibit glomerular filtration, whereas antioxidants prevent this. We set ourselves the goal of clarifying correlations between glomerular filtration, as well as tubular water reabsorption and daily diuresis, on the one hand, and lipoperoxidation parameters, on the other hand. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats 240-290 g, both intact and exposed to water-salt loads. By the size of the diuresis and the level of creatinine in plasma and urine, glomerular filtration and tubular reabsorption were calculated. The plasma levels of diene conjugates and malondyaldehide as well as catalase of plasma and superoxide dismutase of erythrocytes were determined. The levels of the first three parameters determined in urine too. Results. In conditions of water-salt loads accompanied by chronic stress, glomerular filtration is downregulated by malondialdehyde and superoxide dismutase; diuresis is also downregulated by malondialdehyde, but upregulated by catalase. Lipoperoxidation parameters determine kidney function by 52,8%. Conclusion. The obtained data indicate the role of lipoperoxidation as a accompaniment of chronic stress in the regulation of kidney functions.

References

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Published

2021-12-31

How to Cite

1.
ŻUKOW, Xawery & ZAVIDNYUK, Yuriy. Glomerular filtration and diuresis are related to the state of lipids peroxidation in female rats exposed to water-salt loads accompanied by chronic stress. Journal of Education, Health and Sport [online]. 31 December 2021, T. 11, nr 12, s. 481–491. [accessed 29.3.2023]. DOI 10.12775/JEHS.2021.11.12.039.
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Vol. 11 No. 12 (2021)

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Research Articles

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Copyright (c) 2021 Xawery Żukow, Yuriy Zavidnyuk

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