Glucoside-3-cyanidin (Cy3G) and its importance in cancer therapy
DOI:
https://doi.org/10.12775/JEHS.2022.12.07.072Keywords
Anthocyanins, glucoside-3-cyanidin, chemoprevention, antioxidantAbstract
When analyzing the structure of cancer incidence in Poland, it is extremely important to take chemopreventive actions as early as possible, which are aimed at reducing the incidence of the most common cancers, focusing on the prevention and use of natural bioactive factors contained in food. Anthocyanins are a large group of ingredients contained in plants that do not have a nutritional function, but play a significant role in the regulation of metabolic processes in the human body, which has a multidirectional pro-health and preventive effect in relation to many diseases, especially cancer. High hopes in chemoprevention are associated with the biological activity of the most common representative of anthocyanins, i.e. cyanidin-3-glucoside (Cy3G). Most of the studies on Cy3G bioactivity come mainly from in vitro cell line tests and in vivo experimental studies on rodents. Studies of the biological activity of Cy3G most often include: the process of free radical absorption, anti-inflammatory, anticoagulant, insulinotropic, antimicrobial, chemotherapeutic and epigenetic effects. This publication summarizes the results of in vitro studies conducted on various cancer cell lines, which prove the antiproliferative, anti-inflammatory and chemopreventive activity of Cy3G.
References
Baer-Dubowska W. Chemoprewencja – profilaktyka i terapia wspomagana raków głowy i szyi. Postępy w Chirurgii Głowy i Szyi. 2003; 2:3-14.
De Flora S. Mechanisms of inhibitors of mutagenesis and carcinogenesis. Mutat Res. 1998; 402:151-8. doi: 10.1016/s0027-5107(97)00292-3.
Olejnik A., Tomczyk J., Kowalska K., Grajek W. Antocyjany w chemoprewencji nowotworu jelita grubego. Postępy Fitoterapii. 2009; 3:180-188.
American Cancer Society. Cancer facts and figures 2018, www.cancer.org.
Deptała A., Wojtukiewicz M.Z. Rak jelita grubego. Termedia. 2018;1:1-20.
Makowska-Wąs J., Janeczko Z. Biodostępność polifenoli roślinnych. Postępy fitoterapii, 2004; 3:126-137.
Prior R.L., Wu X. Anthocyanins. Structural characteristics that result in unique metabolic patterns and biological activities. Free Radic. Res. 2006; 40:1014-1028. https://doi.org/10.1080/10715760600758522.
Senem Kamiloglu S., Capanoglu E., Grootaert Ch., and van Camp J. Anthocyanin absorption and metabolism by human Intestinal Caco-2 Cells—a review. Int. J. Mol. Sci. 2015; 16: 21555-21574. https://doi.org/10.3390/ijms160921555
Czaplińska M., Czepas J., Gwozdziński K. Budowa, właściwości przeciwutleniające i przeciwnowotworowe flawonoidów. Post. Bioch. 2012; 58: 235- 240.
Björk C.; Wilhelm U., Mandrup S., Larsen B.D., Bordoni A., Hedén P., Rydén M., Arner P., Laurencikiene J. Effects of selected bioactive food compounds on human white adipocyte function. Nutr. Metab.(Lond.). 2016;13. doi 10.1186/s12986-016-0064-3.
Wu X. i wsp. Absorption and metabolism of anthocyanins in elderly woman after consumption of elderberry or blueberry. J. Nutr. 2002; 132:1865. doi.org/10.1093/jn/132.7.1865.
Fang J. Bioavailability of anthocyanins. Drug Metab. Rev. 2014;46:508–520. doi: 10.3109/03602532.2014.978080.
Forbes-Hernández T.Y., Giampieri F., Gasparrini M., Mazzoni L., Quiles J.L., Alvarez-Suarez J.M., Battino M. The effects of bioactive compounds from plant foods on mitochondrial function: A focus on apoptotic mechanisms. Food Chem. Toxicol. 2014; 68:154–182. doi:10.1016/j.fct.2014.03.017.
Castañeda-Ovando A., Pacheco-Hernández M.D.L., Páez-Hernández M.E., Rodríguez, J.A., Galán-Vidal C.A. Chemical studies of anthocyanins: A review. Food Chem. 2009; 113: 859–871 .doi.org/10.1016/j.foodchem.2008.09.001.
Olivas-Aguirre F., Rodrigo-García J., Martínez-Ruiz N., Cárdenas-Robles A., Mendoza-Díaz S., Álvarez-Parrilla E., González-Aguilar G., de la Rosa L., Ramos-Jiménez A., Wall-Medrano A. Cyanidin-3-O-glucoside: Physical-chemistry, foodomics and health effects. Molecules. 2016; 21:1264. doi: 10.3390/molekuły21091264.
Cheynier V., Gómez C., Ageorges A. Flavonoids. Anthocyanins. In Handbook of Analysis of Active Compounds in Functional Foods. Nollet, L.M.C., Toldrá, F., Eds.; CRC Press/Taylor & Francis Group: Boca Raton, FL, USA., 2012; 379–403.
USDA database for the flavonoid content of selected foods – 2018 http://www.nal.usda.gov/.
Fernandes I., Faria A., Calhau C., de Freitas V., Mateus N. Bioavailability of anthocyanins and derivatives. J. Funct. Foods. 2014;7:54–66. doi.org/10.1016/j.jff.2013.05.010.
McGhie T.K., Walton M.C.. The bioavailability and absorption of anthocyanins: Towards a better understanding. Mol. Nutr. Food Res. 2007;51:702–713. https://doi.org/10.1002/mnfr.200700092.
Vogiatzoglou A., Mulligan A.A., Lentjes M.A., Luben R.N., Spencer J.P., Schroeter H., Khaw H., Kuhnle G.G. Flavonoid intake in European adults (18 to 64 years). PLoS ONE. 2015;10: e0128132.doi.org/10.1371/journal.pone.0128132.
Grosso G., Stephania U., Micek A., Stefler D., Bobak M., Paja A. Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study. Eur. J. Nutr. 2016; 56:1409-1420. doi: 10.1007/s00394-016-1187-z.
Peterson J.J., DwyerJ.T., Jacques P.F., McCullough M.L. Improving the estimation of flavonoid intake for study of health outcomes. Nutr. Rev. 2015; 73: 553–576. doi:10.1093/nutrit/nuv008.
D’Evoli L., Tarozzi A., Hrelia P., i wsp. Influence of cultivation system on bioactive molecules synthesis in strawberries: spinoff on antioxidant and antiproliferative activity. Journal of Food Science. 2010; 75: C94–C99. doi: 10.1111/j.1750-3841.2009.01435.x.
Cooke D, Steward WP, Gescher AJ i wsp. Anthocyans from fruits and vegetables – does bright colour signal cancer chemopreventive activity?. Eur J Cancer. 2005; 41:1931-40. doi:10.1016/J.EJCA.2005.06.009.
Fantini M., Benvenuto M., Masuelli L i wsp.: In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment. Int J Mol Sci. 2015;16:9236–9282. doi: 10.3390/ijms16059236.
Kuntz S., Rudloff S., Asseburg H., Borsch C., Fröhling B., Unger F., Dold S., Spengler B., Romp A., Kunz C. Uptake and bioavailability of anthocyanins and phenolic acids from grape/blueberry juice and smoothie in vitro and in vivo. Br. J. Nutr. 2015; 113: 1044–1055. doi:10.1017/S0007114515000161.
Grimes K.L., Stuart C.M., McCarthy J.J., Kaur B., Cantu E.J., Forester S.C. Enhancing the Cancer Cell Growth Inhibitory Effects of Table Grape Anthocyanins. J Food Sci. 2018; 83: 2369-2374. doi: 10.1111/1750-3841.14294.
Sousa A., Araujo P., Azevedo J., Cruz L., Fernandes I., Mateus N., de Freitas V. Antioxidant and antiproliferative properties of 3-deoxyanthocyanidins. Food Chemistry. 2016; 192:142-148. doi: 10.1016/j.foodchem.2015.06.108.
Prescott S.M., White R.L.: Self-promotion? Intimate connections between APC and prostaglandin H synthase-2. Cell. 1996; 87:783-786. doi: 10.1016/s0092-8674(00)81983-2.
Boivin D., Blanchette M., Barrette S., i wsp. Ihibition of cancer cell proliferation and suppression of TNF-induced activation of NF-kB by edible berry juice. Anticancer Res. 2007; 27:937-48.
Seeram N.P., Momin R.A., Borquin L.D., i wsp. Cyclooxygenase inhibitory and antioxidant cyanidin glycosides from cherries and berries. Phytomedicine. 2001; 8: 362-369. doi: 10.1078/0944-7113-00053.
Mazewski C., Liang K., Gonzalez de Mejia E. Comparison of the effect of chemical composition of anthocyanin-rich plant extracts on colon cancer cell proliferation and their potential mechanism of action using in vitro, in silico, and biochemical assays. Food Chemistry. 2018; 242: 378–388. doi: 10.1016/j.foodchem.2017.09.086.
Chen M., Meng H., Zhao Y., Chen F., Yu S. Antioxidant and in vitro anticancer activities of phenolics isolated from sugar beet molasses. BMC Complement Altern Med. 2015; 15:313. doi 10.1186/s12906-015-0847-5.
Chen M., Zhao Z., Yu S. Cytotoxicity and Apoptotic Effects of Polyphenols from Sugar Beet Molasses on Colon Carcinoma Cells in Vitro. Int J Mol Sci. 2016; 17(7): 993. doi:10.3390/ijms17070993.
Anwar S., Fratantonio D., Ferrari D., i wsp. Berry anthocyanins reduce proliferation of human colorectal carcinoma cells by inducing caspase-3 activation and p21 upregulation. Mol Med. 2016; 14:1397–1403. doi: 10.3892/mmr.2016.5397.
Elisia I., Kitts D.D. Anthocyanins inhibit peroxyl radical-induced apoptosis in Caco-2 cells. Mol Cell Biochem. 2008; 312:139-45. doi:10.1007/s11010-008-9729-1.
Ferrari A., Speciale M., Cristani i wsp. Cyanidin-3-O-glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Małgorzata Piątek, Renata Polaniak, Agata Kiciak, Wiktoria Staśkiewicz, Mateusz Grajek
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 738
Number of citations: 0
