Inborn or acquired changes in children under three years of age – a review of the literature
DOI:
https://doi.org/10.12775/JEHS.2022.12.07.024Keywords
mouth abnormalities, newborn, early childhood development, neonateAbstract
This study aimed to discuss some inborn and acquired changes in the oral cavity in young children under three years of age. Based on current literature, eruption cyst, Riga-Fede disease, natal and neonatal teeth, congenital epulis, Epstein pearls, Bohn’s nodules, and gingival cyst of the newborns have been described. The symptoms, clinical presentation, and histological features of these changes, their epidemiology, prevalence, etiopathogenesis, differential diagnosis, and management were taken into consideration to present them accurately. Described oral normal findings and anomalies are not very common, so they require precise diagnosis and management properly. Having relevant knowledge on issues is important both for the pediatricians and pediatric dentists who always cooperate to distinguish the pathology or anomaly and start dealing with it. To our knowledge, this is the first literature review presenting comprehensive and thorough specification of abnormalities occurring in children’s mouth, basing on the most recent scientific literature between 1999 and 2022.
References
Bessa C, Santos P, Aguiar M, do Carmo M. Prevalence of oral mucosal alterations in children from 0 to 12 years old. J Oral Pathol Med. 2004;33(1):17-22.
Majorana A, Bardellini E, Flocchini P, Amadori F, Conti G, Campus G. Oral mucosal lesions in children from 0 to 12 years old: ten years’ experience. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(1):e13-18. doi:10.1016/j.tripleo.2010.02.025
Shulman JD. Prevalence of oral mucosal lesions in children and youths in the USA. Int J Paediatr Dent. 2005;15(2):89-97. doi:10.1111/j.1365-263X.2005.00632.x
Padovani MCRL, Santos MTBR, Sant’anna GR de, Guaré RO. Prevalence of oral manifestations in soft tissues during early childhood in Brazilian children. Braz Oral Res. 2014;28:1-7. doi:10.1590/1807-3107BOR-2014.vol28.0036
de Oliveira AJ, Silveira ML, Duarte DA, Diniz MB. Eruption Cyst in the Neonate. Int J Clin Pediatr Dent. 2018;11(1):58-60. doi:10.5005/jp-journals-10005-1485
Alemán Navas RM, Martínez Mendoza MG, Leonardo MR, Silva RAB da, Herrera HW, Herrera HP. Congenital eruption cyst: a case report. Braz Dent J. 2010;21(3):259-262. doi:10.1590/s0103-64402010000300015
Muraleekrishnan M, Babu P, Pratap T, Parvathy G. Congenital eruption cyst associated with natal. Kerala Dent J. 2011;34(1):23-25.
Şen-Tunç E, Açikel H, Sönmez IS, Bayrak Ş, Tüloğlu N. Eruption cysts: A series of 66 cases with clinical features. Med Oral Patol Oral Cirugia Bucal. 2017;22(2):e228-e232. doi:10.4317/medoral.21499
Bodner L, Goldstein J, Sarnat H. Eruption cysts: a clinical report of 24 new cases. J Clin Pediatr Dent. 2004;28(2):183-186. doi:10.17796/jcpd.28.2.038m4861g8547456
Weber PBG, Ilha MC, Borges TS, Ruschel HC, Kramer PF, Ferreira SH. Eruption cyst associated with tooth rotation on deciduous dentition: A case report. Stomatos. 2015;21(40):21-26.
Gaddehosur CD, Gopal S, Seelinere PT, Nimbeni BS. Bilateral eruption cysts associated with primary molars in both the jaws. BMJ Case Rep. 2014;2014:bcr2013202606. doi:10.1136/bcr-2013-202606
Ricci HA, Parisotto TM, Giro EMA, de Souza Costa CA, Hebling J. Eruption cysts in the neonate. J Clin Pediatr Dent. 2008;32(3):243-246. doi:10.17796/jcpd.32.3.7464433876505u15
Kuczek A, Beikler T, Herbst H, Flemmig TF. Eruption cyst formation associated with cyclosporin A. J Clin Periodontol. 2003;30(5):462-466. doi:10.1034/j.1600-051x.2003.02028.x
Dhawan P, Kochhar GK, Chachra S, Advani S. Eruption cysts: A series of two cases. Dent Res J. 2012;9(5):647-650.
Woldenberg Y, Goldstein J, Bodner L. Eruption cyst in the adult--a case report. Int J Oral Maxillofac Surg. 2004;33(8):804-805. doi:10.1016/j.ijom.2003.10.018
Malhotra P, Malhotra Y, Ohri N, Godara S. Sublingual Tongue Deformity in Infants: Riga-Fede Disease-A Case Report. J Adv Med Dent Sci Res. 2020;8(7):143-145.
Baghdadi ZD. Riga-Fede disease: association with microcephaly. Int J Paediatr Dent. 2002;12(6):442-445. doi:10.1046/j.1365-263x.2002.00396.x
Eley KA, Watt-Smith PA, Watt-Smith SR. Deformity of the tongue in an infant: Riga-Fede disease. Paediatr Child Health. 2010;15(9):581-582. doi:10.1093/pch/15.9.581
Baroni A, Capristo C, Rossiello L, Faccenda F, Satriano RA. Lingual traumatic ulceration (Riga-Fede disease). Int J Dermatol. 2006;45(9):1096-1097. doi:10.1111/j.1365-4632.2004.02554.x
Nawaz K, Krishnamurthy S, Sivakumar S, Selvabalaji, Nawaz M. Riga Fede Disease - A Case Report. J Med Sci Clin Res. 2016;4(5):11089-11091.
Alamankany A. Riga-Fede disease associated with Fabry’s disease and Niemann-Pick C disease in a boy with microcephaly: A case report. Int J Health Sci. 2021;15(1):56-58.
van der Meij EH, de Vries TW, Eggink HF, de Visscher JG. Traumatic lingual ulceration in a newborn: Riga-Fede disease. Ital J Pediatr. 2012;38:20. doi:10.1186/1824-7288-38-20
Costacurta M, Maturo P, Docimo R. Riga-Fede disease and neonatal teeth. ORAL Implantol. 2012;5(1):26-30.
Senanayake MP, Karunaratne I. Persistent lingual ulceration (Riga-Fede disease) in an infant with Down syndrome and natal teeth: a case report. J Med Case Reports. 2014;8:283. doi:10.1186/1752-1947-8-283
Machuca G, Rodríguez S, Vargas M, Suárez C, Bullón P. Management of Riga-Fede disease: a case report. J Disabil Oral Health. 2007;8(1):28-30.
Kariya PB, Shah S, Singh S, Buch A. Riga-Fede Disease Associated with Syndactyly and Oligodactyly: A rare Occurrence. J Clin Pediatr Dent. 2019;43(5):356-359. doi:10.17796/1053-4625-43.5.10
Taghi A, Motamedi MHK. Riga-Fede disease: a histological study and case report. Indian J Dent Res Off Publ Indian Soc Dent Res. 2009;20(2):227-229. doi:10.4103/0970-9290.52893
Slayton RL. Treatment alternatives for sublingual traumatic ulceration (Riga-Fede disease). Pediatr Dent. 2000;22(5):413-414.
Çavuş Ş, Özmen B. Riga-Fede disease in the upper jaw in an infant. Dermatol Ther. 2017;30(5). doi:10.1111/dth.12517
Domingues-Cruz J, Herrera A, Fernandez-Crehuet P, Garcia-Bravo B, Camacho F. Riga-Fede disease associated with postanoxic encephalopathy and trisomy 21: a proposed classification. Pediatr Dermatol. 2007;24(6):663-665. doi:10.1111/j.1525-1470.2007.00564.x
Joseph BK, BairavaSundaram D. Oral traumatic granuloma: report of a case and review of literature. Dent Traumatol Off Publ Int Assoc Dent Traumatol. 2010;26(1):94-97. doi:10.1111/j.1600-9657.2009.00816.x
Zaenglein AL, Chang MW, Meehan SA, Axelrod FB, Orlow SJ. Extensive Riga-Fede disease of the lip and tongue. J Am Acad Dermatol. 2002;47(3):445-447. doi:10.1067/mjd.2002.117213
Leung AKC, Robson WLM. Natal teeth: a review. J Natl Med Assoc. 2006;98(2):226-228.
Mhaske S, Yuwanati MB, Mhaske A, Ragavendra R, Kamath K, Saawarn S. Natal and Neonatal Teeth: An Overview of the Literature. ISRN Pediatr. 2013;2013:956269. doi:10.1155/2013/956269
Cunha RF, Boer FA, Torriani DD, Frossard WT. Natal and neonatal teeth: review of the literature. Pediatr Dent. 2001;23(2):158-162.
Rocha JG, Sarmento LC, Gomes AMM, Valle MAS do, Dadalto ECV. Natal tooth in preterm newborn: a case report. Rev Gaúcha Odontol. 2017;65(2):156-160. doi:10.1590/1981-863720170002000103335
Yen VA, Kuppuswami N. Incidence of Natal Teeth in Newborns in Government Medical College and Hospital, Chengalpattu: A Pilot Study. J Clin Diagn Res JCDR. 2017;11(4):ZC86-ZC88. doi:10.7860/JCDR/2017/25296.9705
Anegundi RT, Sudha R, Kaveri H, Sadanand K. Natal and neonatal teeth : a report of four cases. J Indian Soc Pedod Prev Dent. 2002;20(3):86-92.
Bulut G, Bulut H, Ortac R. A comprehensive survey of natal and neonatal teeth in newborns. Niger J Clin Pract. 2019;22(11):1489-1494. doi:10.4103/njcp.njcp_152_19
Kumar A, Grewal H, Verma M. Posterior neonatal teeth. J Indian Soc Pedod Prev Dent. 2011;29(1):68-70. doi:10.4103/0970-4388.79948
Jamani NA, Ardini YD, Harun NA. Neonatal tooth with Riga-Fide disease affecting breastfeeding: a case report. Int Breastfeed J. 2018;13:35. doi:10.1186/s13006-018-0176-7
Volpato LER, Simões CAD, Simões F, Nespolo PA, Borges ÁH. Riga-Fede Disease Associated with Natal Teeth: Two Different Approaches in the Same Case. Case Rep Dent. 2015;2015:234961. doi:10.1155/2015/234961
Saha A, Sujatha B, Kumar MS, Nuvvula S. Management of Natal Teeth: Paediatric Dentist Role. Dent Craniofacial Res. 2018;3(1):1-3. doi:10.21767/2576-392X.100018
Agarwal N, Madan GK, Sharma A, Agarwal T. Neonatal tooth associated with gingival abscess- A case report. J Dent Spec. 2019;7(1):36-37. doi:10.18231/j.jds.2019.008
Kokubun K, Matsuzaka K, Akashi Y, et al. Congenital Epulis: A Case and Review of the Literature. Bull Tokyo Dent Coll. 2018;59(2):127-132. doi:10.2209/tdcpublication.2017-0028
Ndiokwelu E, Adimora GN, Ibeziako N. Neonatal teeth association with Down’s syndrome. A case report. Odonto-Stomatol Trop Trop Dent J. 2004;27(107):4-6.
El Khatib K, Abouchadi A, Nassih M, et al. [Natal teeth: apropos of five cases]. Rev Stomatol Chir Maxillofac. 2005;106(6):325-327. doi:10.1016/s0035-1768(05)86054-1
Dyment H, Anderson R, Humphrey J, Chase I. Residual neonatal teeth: a case report. J Can Dent Assoc. 2005;71(6):394-397.
Samuel SS, Ross BJ, Rebekah G, Koshy S. Natal and Neonatal Teeth: A Tertiary Care Experience. Contemp Clin Dent. 2018;9(2):218-222. doi:10.4103/ccd.ccd_814_17
Mirza D, Taqvi G, Ikram K, Ahmed S, Hakeem S. Natal and neonatal teeth- an uncommon oral finding: a cross sectional study in Pakistani subjects. Pak Oral Dent J. 2015;35(1):39-43.
Cho W, Nam O, Kim M, Lee H, Kim K, Choi S. Retrospective Study of Clinical Characteristics and Treatments in Natal and Neonatal. J Korean Acad Pediatr Dent. 2017;44(2):188-193. doi:10.5933/JKAPD.2017.44.2.188
Portela MB, Damasceno L, Primo LG. Unusual case of multiple natal teeth. J Clin Pediatr Dent. 2004;29(1):37-39. doi:10.17796/jcpd.29.1.v277031t18553501
Basavanthappa NN, Kagathur U, Basavanthappa RN, Suryaprakash ST. Natal and neonatal teeth: a retrospective study of 15 cases. Eur J Dent. 2011;5(2):168-172.
Triches TC, Mondardo B, Triches RHC, Cordeiro MMR, Cristovam MA da S. Natal and neonatal teeth: two clinical cases report. Rev Gaúcha Odontol. 2018;66(1):101-105. doi:10.1590/1981-863720180001000143377
Dahake PT, Shelke AU, Kale YJ, Iyer VV. Natal teeth in premature dizygotic twin girls. BMJ Case Rep. 2015;2015:bcr2015211930. doi:10.1136/bcr-2015-211930
Kadam M, Kadam D, Bhandary S, Hukkeri RY. Natal and neonatal teeth among cleft lip and palate infants. Natl J Maxillofac Surg. 2013;4(1):73-76. doi:10.4103/0975-5950.117883
Moura LFAD, Moura MS, Lima MDM, Lima CCB, Dantas-Neta NB, Lopes TSP. Natal and neonatal teeth: a review of 23 cases. J Dent Child Chic Ill. 2014;81(2):107-111.
Alaluusua S, Kiviranta H, Leppäniemi A, et al. Natal and neonatal teeth in relation to environmental toxicants. Pediatr Res. 2002;52(5):652-655. doi:10.1203/00006450-200211000-00008
Robotta P, Schafer E. Hallermann-Streiff syndrome: case report and literature review. Quintessence Int Berl Ger 1985. 2011;42(4):331-338.
Shilpy S, Nikhil M, Samir D. Ellis Van Creveld syndrome. J Indian Soc Pedod Prev Dent. 2007;25 Suppl:S5-7.
Kamble A, Dash JK, Sahoo PK, Jadhav G, Velani P. Neonatal tooth with bilateral cleft lip and palate: A case report with review of literature. Indian J Child Health. 2017;4(2):110-113. doi:10.32677/IJCH.2017.v04.i02.001
Anton E, Doroftei B, Grab D, et al. Natal and Neonatal Teeth: A Case Report and Mecanistical Perspective. Healthc Basel Switz. 2020;8(4):E539. doi:10.3390/healthcare8040539
Kamboj M, Chougule RB. Neonatal tooth--how dangerous can it be? J Clin Pediatr Dent. 2009;34(1):59-60. doi:10.17796/jcpd.34.1.27h00760t6271785
Malki GA, Al-Badawi EA, Dahlan MA. Natal teeth: a case report and reappraisal. Case Rep Dent. 2015;2015:147580. doi:10.1155/2015/147580
Rocha RM, Silva GV e, de Albuquerque DC, Tura BR, Albanesi Filho FM. Influence of spironolactone therapy on thiamine blood levels in patients with heart failure. Arq Bras Cardiol. 2008;90(5):324-328.
Lapid O, Shaco-Levy R, Krieger Y, Kachko L, Sagi A. Congenital epulis. Pediatrics. 2001;107(2):E22. doi:10.1542/peds.107.2.e22
Bawazir OA, Al-Salem AH. Granular cell tumor (Epulis): Simple excision is the treatment of choice. J Clin Neonatol. 2019;8(3):166. doi:10.4103/jcn.JCN_60_19
Zerener T, Sencimen M, Altun C, Altug HA. Congenital granular cell tumor in newborn. Eur J Dent. 2013;7(4):497-499. doi:10.4103/1305-7456.120651
Aparna H, Jayanth B, Shashidara R, Jaishankar P. Congenital Epulis in a Newborn: A Case Report, Immunoprofiling and Review of Literature. Ethiop J Health Sci. 2014;24(4):359-362.
Merglová V, Mukensnabl P, Andrle P. Congenital epulis. BMJ Case Rep. 2012;2012:bcr0120125483. doi:10.1136/bcr.01.2012.5483
Gnassingbe K, Mihluedo-Agbolan KA, Bissa H, et al. Congenital giant epulis obstructing oral cavity: newborn emergency. Pan Afr Med J. 2014;17:195. doi:10.11604/pamj.2014.17.195.3023
Jain N, Sinha P, Singh L. Large Congenital Epulis in a Newborn: Diagnosis and Management. Ear Nose Throat J. 2020;99(7):NP79-NP81. doi:10.1177/0145561319851498
Bhatia SK, Goyal A, Ritwik P, Rai S. Spontaneous regression of a congenital epulis in a newborn. J Clin Pediatr Dent. 2013;37(3):297-299. doi:10.17796/jcpd.37.3.m1n1425821896807
McGuire TP, Gomes PP, Freilich MM, Sándor GKB. Congenital epulis: a surprise in the neonate. J Can Dent Assoc. 2006;72(8):747-750.
Ritwik P, Brannon RB, Musselman RJ. Spontaneous regression of congenital epulis: a case report and review of the literature. J Med Case Reports. 2010;4:331. doi:10.1186/1752-1947-4-331
Pathak M, Narula D. Case series of gingival granular cell tumor—A revelation in neonates. J Oral Maxillofac Surg Med Pathol. 2016;28(4):328-330. doi:10.1016/j.ajoms.2016.02.004
Liang Y, Yang YS, Zhang Y. Multiple congenital granular cell epulis in a female newborn: a case report. J Med Case Reports. 2014;8:413. doi:10.1186/1752-1947-8-413
Sharma D, Murki S, Pratap T, Leelakumar V. Twin congenital epulis in the alveolar ridge of the maxilla and mandible in a newborn: a rare and interesting case. BMJ Case Rep. 2014;2014:bcr2014206490. doi:10.1136/bcr-2014-206490
Diniz MB, Giro Elisa MA, Zuanon Angela CC, Costa CA, Hebling J. Congenital epulis: a rare benign tumor in the newborn. J Indian Soc Pedod Prev Dent. 2010;28(3):230-233. doi:10.4103/0970-4388.73787
Saki N, Araghi S. Multiple congenital epulis in alveolar ridges of maxilla and mandible in a newborn: a rare case report. Case Rep Otolaryngol. 2014;2014:606985. doi:10.1155/2014/606985
Hasanov A, Musayev J, Onal B, Rahımov C, Farzaliyev I. Gingival granular cell tumor of the newborn: a case report and review of literature. Turk Patoloji Derg. 2011;27(2):161-163. doi:10.5146/tjpath.2011.01067
Kumar S, Prasad C, Thomas M, Koshy S. Congenital epulides: a rare case report. Indian J Dent Res Off Publ Indian Soc Dent Res. 2014;25(6):806-808. doi:10.4103/0970-9290.152209
Kim ES, Gross TL. Prenatal ultrasound detection of a congenital epulis in a triple X female fetus: a case report. Prenat Diagn. 1999;19(8):774-776.
Tandon P, Malik R, Tandon R. Congenital epulis of the newborn: a case report with review of literature. Indian J Pathol Microbiol. 2007;50(3):593-594.
Cheung JM, Putra J. Congenital Granular Cell Epulis: Classic Presentation and Its Differential Diagnosis. Head Neck Pathol. 2019;14(1):208-211. doi:10.1007/s12105-019-01025-1
Kim SK, Won HS, Lee SW, et al. Prenatal diagnosis of congenital epulis by three-dimensional ultrasound and magnetic resonance imaging. Prenat Diagn. 2006;26(2):171-174. doi:10.1002/pd.1368
Yavuzer R, Ataoğlu O, Sari A. Multiple congenital epulis of the alveolar ridge and tongue. Ann Plast Surg. 2001;47(2):199-202. doi:10.1097/00000637-200108000-00017
Dhareula A, Jaiswal M, Goyal A, Gauba K. Congenital granular cell tumor of the newborn - Spontaneous regression or early surgical intervention. J Indian Soc Pedod Prev Dent. 2018;36(3):319-323. doi:10.4103/JISPPD.JISPPD_1187_17
Wang IJ, Lin SL, Tsou KI, et al. Congenital midline nasal mass: cases series and review of the literature. Turk J Pediatr. 2010;52(5):520-524.
Lee JM, Kim UK, Shin SH. Multiple congenital epulis of the newborn: A case report and literature review. J Pediatr Surg Case Rep. 2013;1(3):32-33. doi:10.1016/j.epsc.2013.03.002
Khattala K, Rami M, Elmadi A, Chbani L, Bouabdallah Y. A case report of a huge congenital granular cell epulis operated under local anesthesia. Pan Afr Med J. 2012;12:105.
Conrad R, Perez MCN. Congenital granular cell epulis. Arch Pathol Lab Med. 2014;138(1):128-131. doi:10.5858/arpa.2012-0306-RS
Perez-Aguirre B, Soto-Barreras U, Loyola-Rodriguez JP, et al. Oral findings and its association with prenatal and perinatal factors in newborns. Korean J Pediatr. 2018;61(9):279-284. doi:10.3345/kjp.2017.06177
George D, Bhat SS, Hegde SK. Oral findings in newborn children in and around Mangalore, Karnataka State, India. Med Princ Pract Int J Kuwait Univ Health Sci Cent. 2008;17(5):385-389. doi:10.1159/000141502
Silva A, Matos P, Marras L, VanderleY G, Lacerda G, Arruda H. Prevalence of Epstein’s pearls and Bohn’s nodules among congenital oral abnormalities. Int J Pediatr Res Rev. 2020;3. doi:10.28933/ijoprr-2020-01-2105
Lopes LC, Silva AF, Cruz ITSA da, Fraiz FC, Assunção LR da S. Oral Findings in Brazilian Infants Born at Full Term. Pesqui Bras Em Odontopediatria E Clínica Integrada. 2016;16(1). Accessed September 23, 2021. https://www.redalyc.org/articulo.oa?id=63749588030
Greenberg JA, Bell SJ, Guan Y, Yu Y hong. Folic Acid Supplementation and Pregnancy: More Than Just Neural Tube Defect Prevention. Rev Obstet Gynecol. 2011;4(2):52-59.
Benni D, Sirur D. Gingival cyst of the newborn: A case report. Int Dent - Aust Ed. 2013;8(2):32-34.
Niranjan MM, Srivastava N, Rana V, Chandna P. Assessment of Intraoral Findings of Neonates, Born in and around Meerut City. Int J Clin Pediatr Dent. 2020;13(1):48-52. doi:10.5005/jp-journals-10005-1584
Madathil J, Negi BS, Kumar NR. Gingival cyst of new born: a case report. Int J Contemp Pediatr. 2016;3(3):1129-1131. doi:10.18203/2349-3291.ijcp20162409
Marini R, Chipaila N, Monaco A, Vitolo D, Sfasciotti GL. Unusual symptomatic inclusion cysts in a newborn: a case report. J Med Case Reports. 2014;8:314. doi:10.1186/1752-1947-8-314
Brij D, Shabir B, Daraz H. Dental lamina cyst - a case report. Eur J Pharm Med Res. 440AD;6(11):2019.
Kolay S, Purkait S, Mishra M, Jha P, Sinha R. Gingival Cyst of Newborn: A Case Report. J Clin Denentistry Res Educ. 2013;2(3):38-40.
Moda A. Gingival Cyst of Newborn. Int J Clin Pediatr Dent. 2011;4(1):83-84. doi:10.5005/jp-journals-10005-1087
Monteagudo B, Labandeira J, Cabanillas M, Acevedo A, León-Muiños E, Toribio J. Prevalence of milia and palatal and gingival cysts in Spanish newborns. Pediatr Dermatol. 2012;29(3):301-305. doi:10.1111/j.1525-1470.2011.01433.x
Donley CL, Nelson LP. Comparison of palatal and alveolar cysts of the newborn in premature and full-term infants. Pediatr Dent. 2000;22(4):321-324.
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