Advanced oxidation protein products — biological marker of oxidative stress = Zaawansowane produkty utleniania białek – biologiczne markery stresu oksydacyjnego

Abstract

Cwynar Anna, Olszewska-Słonina Dorota, Czerniak Bartosz, Źyła Magdalena. Advanced oxidation protein products — biological marker of oxidative stress = Zaawansowane produkty utleniania białek – biologiczne markery stresu oksydacyjnego. Journal of Education, Health and Sport. 2016;6(9):597-603. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.155059

http://ojs.ukw.edu.pl/index.php/johs/article/view/3885

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© The Author (s) 2016;

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 02.09.2016. Revised 24.09.2016. Accepted: 24.09.2016.

Advanced oxidation protein products — biological marker of oxidative stress

Zaawansowane produkty utleniania białek – biologiczne markery stresu oksydacyjnego

Anna Cwynar¹, Dorota Olszewska-Słonina¹, Bartosz Czerniak¹, Magdalena Źyła²

¹ Katedra Patobiochemii i Chemii Klinicznej, Collegium Medicum w Bydgoszczy

² Katedra Psychiatrii, Collegium Medicum w Bydgoszczy

ABSTRACT

Advanced oxidation protein products (AOPPs) are mostly derivatives of oxidatively modified albumin. The results of many experimental studies confirm intensification of oxidative modifications of proteins and an increase in concentration of advanced oxidation protein products (AOPPs) in different pathological conditions, particularly those with well documented involvement of oxidative stress in their etiopathogenesis, but also those where its role is not yet well understood. Currently intensive research is carried out on the possibility of using AOPPs as useful indicators for diagnosing, prognosis and monitoring of diseases.

Keywords: advanced oxidation protein products, autoimmune disease, oxidative stress

STRESZCZENIE

Zaawansowane produkty utleniania białek (AOPPs), to najczęściej pochodne zmodyfikowanej oksydacyjnie albuminy. Wyniki licznych badań doświadczalnych potwierdzają nasilenie oksydacyjnych modyfikacji białek i wzrost stężenia zaawansowanych produktów utleniania białek (AOPPs) w różnych stanach patologicznych, szczególnie tych o dobrze udokumentowanym udziale stresu oksydacyjnego w ich etiopatogenezie, ale także takich, w których jego rola nie jest jeszcze dobrze poznana.. Obecnie trwają intensywne badania nad możliwością wykorzystania AOPPs, jako użytecznych wskaźników do diagnozowania, prognozowania oraz monitorowania chorób.

Słowa kluczowe: zaawansowane produkty utleniania białek, choroby autoimmunologiczne, stres oksydacyjny