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Journal of Education, Health and Sport

Normal bilirubinemia downregulates the power spectral density of the θ and Δ rhythm, instead upregulates the β rhythm and sympatho-vagal balance in adults humans
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  • Normal bilirubinemia downregulates the power spectral density of the θ and Δ rhythm, instead upregulates the β rhythm and sympatho-vagal balance in adults humans
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Normal bilirubinemia downregulates the power spectral density of the θ and Δ rhythm, instead upregulates the β rhythm and sympatho-vagal balance in adults humans

Authors

  • Mykhaylo Korda IY Horbachevs’kyi National Medical University, Ternopil’ https://orcid.org/0000-0003-0676-336X
  • Anatoliy Gozhenko Ukrainian Scientific Research Institute of Medicine for Transport Ministry of Health, Odesa https://orcid.org/0000-0001-7413-4173
  • Igor Kuchma Ukrainian Scientific Research Institute of Medicine for Transport Ministry of Health, Odesa https://orcid.org/0000-0003-3239-4107
  • Inna Korda IY Horbachevs’kyi National Medical University, Ternopil’ https://orcid.org/0000-0002-2224-3308
  • Oleksandr Popadynets’ Ukrainian Scientific Research Institute of Medicine for Transport Ministry of Health, Odesa https://orcid.org/0000-0001-5415-2542
  • Nataliya Badiuk Ukrainian Scientific Research Institute of Medicine for Transport Ministry of Health, Odesa https://orcid.org/0000-0002-8290-0605
  • Tetyana Korolyshyn Ukrainian Scientific Research Institute of Medicine for Transport Ministry of Health, Odesa; OO Bohomolets’ Institute of Physiology of NAS, Kyїv https://orcid.org/0000-0002-2276-8745
  • Walery Zukow Nicolaus Copernicus University, Torun https://orcid.org/0000-0002-7675-6117
  • Igor Popovych Ukrainian Research Institute of Medicine for Transport, Odesa; OO Bohomolets’ Institute of Physiology, Kyїv https://orcid.org/0000-0002-5664-5591

DOI:

https://doi.org/10.12775/JEHS.2022.12.01.039

Keywords

bilirubinemia, EEG, HRV, relationships, adults humans

Abstract

Background. Neonatal hyperbilirubinemia has been known to damage neural function. Our goal is to determine whether the neurotropic activity of normal bilirubinemia in adults is evident. Methods. The object of observation were 77 volunteers: 30 women and 47 men aged 49±13 (26 ÷ 76) years without clinical diagnosis. Testing was performed twice with an interval of 4 ÷ 10 days. We determined the plasma levels of the direct and free bilirubin, recorded EEG and HRV followed by analysis of correlations between parameters. Results. Significant downregulating effect of bilirubinemia was found on power spectrum density (PSD) theta and delta rhythm. In contrast, bilirubinemia has an upregulating effect on PSD beta rhythm and sympatho-vagal balance. The canonical correlation between direct & free bilirubin levels, on the one hand, and EEG & HRV parameters, on the other hand, is very strong: R=0,808; R2=0,654; χ2(80)=191; p<10-6 (n=154). A similar canonical correlation was found between individual changes in parameters: R=0,753; R2=0,568; χ2(48)=83; p=0,001 (n=74). Conclusion. Even normal bilirubinemia has an downregulating effect on mainly theta and delta rhythm-generating nuclei and vagal tone, while upregulating effects on sympathetic tone and beta rhythm-generating nuclei.

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Journal of Education, Health and Sport

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2022-01-31

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KORDA, Mykhaylo, GOZHENKO, Anatoliy, KUCHMA, Igor, KORDA, Inna, POPADYNETS’, Oleksandr, BADIUK, Nataliya, KOROLYSHYN, Tetyana, ZUKOW, Walery & POPOVYCH, Igor. Normal bilirubinemia downregulates the power spectral density of the θ and Δ rhythm, instead upregulates the β rhythm and sympatho-vagal balance in adults humans. Journal of Education, Health and Sport [online]. 31 January 2022, T. 12, nr 1, s. 454–472. [accessed 26.3.2023]. DOI 10.12775/JEHS.2022.12.01.039.
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Copyright (c) 2022 Mykhaylo Korda, Anatoliy Gozhenko, Igor Kuchma, Inna Korda, Oleksandr Popadynets’, Nataliya Badiuk, Tetyana Korolyshyn, Walery Zukow, Igor Popovych

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