Pulmonary embolism in COVID-19
DOI:
https://doi.org/10.12775/JEHS.2022.12.02.030Keywords
COVID-19, PE, D-dimer, coagulopathyAbstract
COVID-19 pandemic is recognized as a present day major public health burden. Risk factors for developing a more severe course of COVID-19 include increased levels of C-reactive protein and D-dimer. Pulmonary embolism (PE) is challenging in patients with COVID-19. The purpose: to analyze clinical and paraclinical manifestations of PE in patients with COVID-19 in order to develop a system for its early diagnosis, prediction of complications, prevention and treatment. 52 patients aged 28 - 81 y.o. with a diagnosis "Acute respiratory disease COVID-19" have been examined during 2020-2021. (98.08±1.9)% of PE patients had a history of one or more comorbidities, including obesity (80.77%), coronary heart disease (96.15%), hypertension (98.08%), peripheral arteries (92.3%), type 2 diabetes mellitus (48.08%). Evaluation of laboratory parameters revealed increasing lymphocytopenia, leukocytosis, neutrophilia, thrombocytopenia (p<0.05). Biochemical parameters showed high CRP, increase in creatinine, decrease in glomerular filtration rate (p<0.05). A direct relationship was found between overweight and an increase in the content of C-RP in COVID-19 and PE patients. Conclusions: age over 65, hypertension and obesity are risk factors for severe course of COVID-19 and PE.
References
DiMinno, A., Ambrosino, P., Calcaterra, I., &DiMinno, M. (2020). COVID-19 and Venous Thromboembolism: A Meta-analysis of Literature Studies. Seminars in thrombosis and hemostasis, 46(7), 763–771. 9
Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72?314 cases from the chinese center for disease control and prevention. JAMA. 2020. [PMID: 32091533] doi:10.1001/jama.2020.2648.
World statistics COVID-19. Access mode: https://covid.observer/.ru/ (in Russian)
Kharchenko Yu. P., Zaretskaya AV, Buyko OO, Ilyina-Stognienko V. Yu. Features of the clinical and paraclinical course of COVID-19 in children. Herald for Marine Medicine. 2021. - N 2. - P. 8 – 14 (in Ukrainian)
Tang N, Li D, Wang X, et al. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18:844-847. [PMID: 32073213] doi:10.1111/jth.14768.
Wichmann D, Sperhake JP, Lütgehetmann M, et al. Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study. Ann Intern Med. 2020;173(4):268-277. doi:10.7326/M20-2003
Middeldorp, S., Coppens, M., van Haaps, T. F., Foppen, M., Vlaar, A. P., Müller, M., Bouman, C., Beenen, L., Kootte, R. S., Heijmans, J., Smits, L. P., Bonta, P. I., & van Es, N. (2020). Incidence of venous thromboembolism in hospitalized patients with COVID-19. Journal of thrombosis and haemostasis : JTH, 18(8), 1995–2002.
Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844‐847.
Palm, V., Rengier, F., Rajiah, P., Heussel, C. P., & Partovi, S. (2020). Acute Pulmonary Embolism: Imaging Techniques, Findings, Endovascular Treatment and Differential Diagnoses. Akute Lungenarterienembolie: Bildgebung, Bildbefunde, endovaskuläre Therapie und Differenzialdiagnosen. Ro Fo :Fortschritte auf demGebiete der Rontgenstrahlen und der Nuklearmedizin, 192(1), 38–49. https://doi.org/10.1055/a-0900-4200
Raja AS, Greenberg JO, Qaseem A. et al. Evaluation of Patients With Suspected Acute Pulmonary Embolism: Best Practice Advice From the Clinical Guidelines Committee of the American College of Physicians. Ann Intern Med 2015; 163: 701-711
Konstantinides SV, Torbicki A, Agnelli G. etal. 2014 ESC guidelines on the diagnosis andm anagement of acute pulmonary embolism. Eur Heart J 2014; 35: 3033-3069, 3069a-3069k
Middeldorp S, Coppens M, van Haaps TF, et al. . Incidence of venous thromboembolism in hospitalized patients with COVID-19. Preprints 2020; preprint
Wu C, Chen X, Cai Y. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease - 2019 pneumonia in Wuhan, China JAMA Intern Med2020; Doi: 10.1001/jamainternmed.2020.0994
Mo P, Xing Y, Xiao Y. Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China Clin Infect Dis2020; Doi: 10.1093/cid/ciaa270
World Health Organization Corona virus disease 2019 (COVID-19): Situation Report, 51 2020. Available at:https://apps.who.int/iris/handle/10665/331475. Accessed July 15, 2020
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