The ketogenic diet in the treatment of diabetes type 2
DOI:
https://doi.org/10.12775/JEHS.2022.12.07.009Keywords
diet, ketogenic, type 2 diabetes, obesityAbstract
Despite advances in the medical world, obesity remains a major worldwide health hazard .The majority of chronic diseases like diabetes is largely related to obesity which is usually a product of an unhealthy lifestyle and poor dietary habits. The ketogenic diet has become an increasingly popular approach for both weight loss and as an alternative diet for type 2 diabetes mellitus (T2DM). In addition, this diet has a positive effect on body weight, blood glucose level, glycosylated hemoglobin and plasma lipid profile. This review focuses on the therapeutic effectiveness of using LCKD for the treatment of type 2 diabetes.
References
Veech R.L. The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: Ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot. Essent. Fat. Acids. 2004;70:309–319. doi: 10.1016/j.plefa.2003.09.007. [PubMed] [CrossRef] [Google Scholar]
AB Olokoba, OA Obateru, LB Olokoba. Type 2 diabetes mellitus: a review of current trends Oman Med J, 27 (2012), pp. 269-273
P Saeedi, I Petersohn, P Salpea, B Malanda, S Karuranga, N Unwin, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition Diabetes Res Clin Pract, 157 (2019), Article 107843
American Diabetes A. 5. Facilitating behavior change and well-being to improve health outcomes: standards of medical care in diabetes-2021. Diabetes Care. 2021;44(Suppl 1):S53-S72. 10.2337/dc21-S005. Most recent American guidelines for lifestyle management in prediabetes and diabetes. [PubMed]
Colberg SR, Sigal RJ, Yardley JE, Riddell MC, Dunstan DW, Dempsey PC, Horton ES, Castorino K, Tate DF. Physical activity/exercise and diabetes: a position statement of the American Diabetes Association. Diabetes Care. 2016;39(11):2065–2079. doi: 10.2337/dc16-1728. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Evert AB, Dennison M, Gardner CD, Garvey WT, Lau KHK, MacLeod J, et al. Nutrition therapy for adults with diabetes or prediabetes: a consensus report. Diabetes Care. 2019;42(5):731–754. doi: 10.2337/dci19-0014. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev. 1999;15(6):412–426. doi: 10.1002/(sici)1520-7560(199911/12)15:6<412::aid-dmrr72>3.0.co;2-8. [PubMed] [CrossRef] [Google Scholar]
Dashti HM, Mathew TC, Khadada M, Al-Mousawi M, Talib H, Asfar SK, et al. Beneficial effects of ketogenic diet in obese diabetic subjects. Mol Cell Biochem. 2007;302((1–2)):249–56. [PubMed] [Google Scholar] [Ref list]
Dashti HM, Al-Zaid NS, Mathew TC, Al-Mousawi M, Talib H, Asfar SK, et al. Long term effects of ketogenic diet in obese subjects with high cholesterol level. Mol Cell Biochem. 2006;286((1–2)):1–9. [PubMed] [Google Scholar] [Ref list]
Dashti HM, Mathew TC, Al-Zaid NS. Efficacy of Low-Carbohydrate Ketogenic Diet in the Treatment of Type 2 Diabetes. Med Princ Pract. 2021;30(3):223-235. doi:10.1159/000512142
Li S, Lin G, Chen J, Chen Z, Xu F, Zhu F, Zhang J, Yuan S. The effect of periodic ketogenic diet on newly diagnosed overweight or obese patients with type 2 diabetes. BMC Endocr Disord. 2022 Feb 3;22(1):34. doi: 10.1186/s12902-022-00947-2. PMID: 35115003; PMCID: PMC8811985.
Effects of ketogenic diets on cardiovascular risk factors: evidence from animal and human studies. Kosinski C, Jornayvaz FR. Nutrients. 2017;9:517. [PMC free article] [PubMed] [Google Scholar] [Ref list]
Nymo S, Coutinho SR, Jørgensen J, Rehfeld JF, Truby H, Kulseng B, et al. Timeline of changes in appetite during weight loss with a ketogenic diet. Int J Obes (Lond) 2017;41(8):1224–31. doi: 10.1038/ijo.2017.96. [PMC free article] [PubMed] [CrossRef] [Google Scholar] [Ref list]
Paoli A, Rubini A, Volek JS, Grimaldi KA. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. Eur J Clin Nutr. 2013;67(8):789–96. doi: 10.1038/ejcn.2013.116. [PMC free article] [PubMed] [CrossRef] [Google Scholar] [Ref list]
Li, S., Lin, G., Chen, J., Chen, Z., Xu, F., Zhu, F., Zhang, J., & Yuan, S. (2022). The effect of periodic ketogenic diet on newly diagnosed overweight or obese patients with type 2 diabetes. BMC endocrine disorders, 22(1), 34. https://doi.org/10.1186/s12902-022-00947-2
Dashti, H. M., Mathew, T. C., & Al-Zaid, N. S. (2021). Efficacy of Low-Carbohydrate Ketogenic Diet in the Treatment of Type 2 Diabetes. Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 30(3), 223–235. https://doi.org/10.1159/000512142
Dashti HM, Mathew TC, Al-Zaid NS. Efficacy of Low-Carbohydrate Ketogenic Diet in the Treatment of Type 2 Diabetes. Med Princ Pract. 2021;30(3):223-235. doi: 10.1159/000512142. Epub 2020 Oct 9. PMID: 33040057; PMCID: PMC8280429.
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Copyright (c) 2022 Karolina Raksa, Mateusz Pawlina, Karolina Ziętara, Martyna Lewkowicz, Katarzyna Nowakowska, Przemysław Raczkiewicz
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