Therapeutic and preventive effect of the antidisbiotic agent kvertulin on the condition of the oral cavity of patients who received oral applications of fried sunflower oil
DOI:
https://doi.org/10.12775/JEHS.2022.12.05.011Keywords
fried oil, oral cavity, antidisbiotic agent, inflammation, dysbiosisAbstract
Background. To determine the possibility of prevention of dental complications in the consumption of fried sunflower oil (FSO) with the antidisbiotic agent Kvertulin.
Methods. Patients underwent oral FSO applications for 10 days. The antidisbiotic agent was taken sublingually. The condition of the oral cavity was assessed by such indicators as salivation rate, hygienic indices, level in saliva of biochemical markers of inflammatory-dystrophic (elastase, MDA, urease), dysbiotic processes (urease, lysozyme, degree of dysbiosis) and antioxidant protection (catalase, index API).
Results. It was found that the consumption of FSO increases the level of elastase, urease, MDA and the degree of dysbiosis in saliva, but reduces the level of lysozyme, catalase and API index. Previous use of Kvertulin significantly reduced the level of elastase, urease, MDA and the degree of dysbiosis and increased the level of lysozyme, catalase and API index. The therapeutic and prophylactic efficacy of quertulin in the patients who consumption of FSO was 64.4 %.
Conclusion: Consumption of FSO causes the development of inflammatory-dystrophic and dysbiotic complications in the oral cavity, which can be largely prevented with the antidisbiotic agent Kvertulin.
References
Labush IuZ. The development of stomatitis in rats that consumed рeroxidе sunflower oil. Dentistry Bulletin. 2018;28(2(103):17-20. (in Ukrainian)
Labush IuZ. Prevention by anti-dysbiosis mucosal adhesive gels stomatitis in rats treated with oral applications of peroxide sunflower oil. Dentistry Bulletin. 2019;10:10-13. (in Ukrainian)
Labush IuZ, Markov AV, Zubachik VМ, Levitsky AP. Mucosoprotective effect of lysozyme-forte in rats that received super-oxidized sunflower oil. Marine Medicine Bulletin. 2018;2(79):75-79. (in Ukrainian)
Markov AV, Labush IuZ, Zubachik VМ [and others]. Therapeutic and preventive action flavan-containing antidisbiotic means on a mucose membrane of the oral cavity of the rats, received peroxide sunflower oil. Phytotherapy. Magazine. 2018;2:33-35. (in Ukrainian)
Levitsky AP, Makarenko OA, Selivanskaya IA [and others]. “Querthulin”, Vitamin P, prebiotic, hepatoprotector. Оdеssа, KP OGT, 2012:20. (in Russian)
Levitsky AP. Fried butter: benefit or harm? Оdеssа, Ecology, 2021:42. (in Russian)
Levitsky AP, Makarenko OA, Demyanenko SA. Methods of experimental dentistry (teaching aid). Simferopol, Tarpan, 2018:78. (in Russian)
Lowry OH, Rosebrough NJ, Farr AL [and others]. Protein measurement with Folin phenol reagent. Biol. Chem. 1951;193:265-275.
Levitsky AP, Makarenko OA, Selivanskaya IA [and others]. Enzymatic methods for determination of oral dysbiosis for screening pro- and prebiotics: method guidelines. Кiev, GFC, 2007:22. (in Russian)
Mashchenko IS. Paradontal diseases. Dneproprtrovsk, KOLO, 2003:272. (in Russian)
Truhacheva NV. Mathematical Statistics in biomedical research using application package Statistica. Moskva, GJeOTAR-Media, 2012:379. (in Russian)
Levitsky AP, Stefanov AV. The methods of the determination of the activity of elastase and its inhibitors: method guidelines. Kiev, GFK, 2002:15. (in Russian)
Nizhevich AA, Khasanov RIu. Urease Helicobacter pylori: introduce in pathogenesis and pathbiochemistry of gastritis. Materialy VIII tematicheskoi sessii Rossiiskoi gruppy po izucheniiu Helicobacter pylori, 18.5.1999. – Ufa: 1-9. Materials of the VIII thematic session of the Russian Group for the Study of Helicobacter pylori. (in Russian)
Levashov PA, Matolygina DA, Ovchinnikova ED [and others]. New sorbent based on covalently immobilized lysozyme to remove bacterial lipopolysaccharide (endotoxin) from biological fluids. Biochemistry. 2019;84(1):100-108. (in Russian)
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