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Journal of Education, Health and Sport

Obesity treatment - overview of pharmacological and surgical methods
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  • Obesity treatment - overview of pharmacological and surgical methods
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  3. Vol. 12 No. 7 (2022) /
  4. Review Articles

Obesity treatment - overview of pharmacological and surgical methods

Authors

  • Joanna Osiak Collegium Medicum Nicolaus Copernicus University https://orcid.org/0000-0002-6310-9981
  • Karolina Mikut Collegium Medicum Nicolaus Copernicus University https://orcid.org/0000-0001-7022-581X
  • Aleksandra Wijata Collegium Medicum Nicolaus Copernicus University https://orcid.org/0000-0001-6263-1826
  • Kornelia Kędziora-Kornatowska Collegium Medicum Nicolaus Copernicus University https://orcid.org/0000-0003-4777-5252

DOI:

https://doi.org/10.12775/JEHS.2022.12.07.005

Keywords

obesity, bariatric surgery, treatment

Abstract

Introduction and purpose of the work: Obesity is a chronic disease that leads to many complications. Almost a third of the world's population is now classified as overweight or obese. This is a huge global problem. The base of treatment is diet and physical activity, but fortunately nowadays we also have pharmacological and surgical treatment - which are increasingly used. The aim of this study is to draw attention to obesity disease which may lead to serious complications and compare available pharmacological and surgical treatment.

State of knowledge (brief description): Treating obesity is a difficult and often multidisciplinary challenge. Currently many drugs with different mechanisms and different efficiencies has been approved for treatment. All of them show efficiency, but the available studies show that surgical treatment produces better results than pharmacological treatment. 

Summary: We currently have a huge range of obesity treatment options available. Surgical treatment produces better results than pharmacological treatment. Nevertheless, not every patient qualifies for bariatric surgery. Pharmacological methods are also effective. The treatment method should be individually selected for the patient.

References

World Health Organization Obesity and overweight. Fact sheet no 311 January 2015

Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019 Mar;92:6-10.

Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006 Dec 14;444(7121):840-6.

Seravalle G, Grassi G. Obesity and hypertension. Pharmacol Res. 2017 Aug;122:1-7.

Ebong IA, Goff DC Jr, Rodriguez CJ, Chen H, Bertoni AG. Mechanisms of heart failure in obesity. Obes Res Clin Pract. 2014 Nov-Dec;8(6):e540-5.

Cawley J, Biener A, Meyerhoefer C, Ding Y, Zvenyach T, Smolarz BG, Ramasamy A. Direct medical costs of obesity in the United States and the most populous states. J Manag Care Spec Pharm. 2021 Mar;27(3):354-366.

Guideline Central. Pharmacological Management of Obesity. Available: https://www.guidelinecentral.com/guideline/41606/ [ Accessed 6th May 2022].

Saunders KH, Umashanker D, Igel LI, Kumar RB, Aronne LJ. Obesity Pharmacotherapy. Med Clin North Am. 2018 Jan;102(1):135-148.

Khera R, Murad MH, Chandar AK, Dulai PS, Wang Z, Prokop LJ, Loomba R, Camilleri M, Singh S. Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events: A Systematic Review and Meta-analysis. JAMA. 2016 Jun 14;315(22):2424-34.

Torgerson JS, Hauptman J, Boldrin MN, Sjöström L. XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care. 2004 Jan;27(1):155-61.

Ladenheim EE. Liraglutide and obesity: a review of the data so far. Drug Des Devel Ther. 2015; 9: 1867–1875.

Kelly AS, Auerbach P, Barrientos-Perez M, Gies I, Hale PM, Marcus C, Mastrandrea LD, Prabhu N, Arslanian S. A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity. N Engl J Med 2020; 382:2117-2128

Garvey WT, Birkenfeld AL, Dicker D, Mingrone G, Pedersen SD, Satylganova A, Skovgaard D, Sugimoto D, Jensen C, Mosenzon O. Efficacy and Safety of Liraglutide 3.0 mg in Individuals With Overweight or Obesity and Type 2 Diabetes Treated With Basal Insulin: The SCALE Insulin Randomized Controlled Trial. Diabetes Care. 2020 May; 43(5): 1085–1093.

Smits MM, Van Raalte DH. Safety of Semaglutide. Front Endocrinol (Lausanne). 2021; 12: 645563.

Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989

O'Neil PM, Birkenfeld AL, McGowan B, Mosenzon O, Pedersen SD, Wharton S, Charlotte Carson G, Jepsen CH, Kabisch M, Wilding JPH. Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial. Lancet. 2018 Aug 25;392(10148):637-649.

Apovian CM, Aronne L, Rubino D, Still C, Wyatt H, Burns C, Kim D, Dunayevich E. A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II). Obesity (Silver Spring). 2013 May;21(5):935-43.

Gadde KM, Allison DB, Ryan DH, Peterson CA, Troupin B, Schwiers ML, Day WW. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet. 2011 Apr 16;377(9774):1341-52.

Allison DB, Gadde KM, Garvey WT, Peterson CA, Schwiers ML, Najarian T, Tam PY, Troupin B, Day WW. Controlled-Release Phentermine/Topiramate in Severely Obese Adults: A Randomized Controlled Trial (EQUIP). Obesity (Silver Spring). 2012 Feb; 20(2): 330–342

Colquitt JL, Pickett K, Loveman E, Frampton GK. Surgery for weight loss in adults. Cochrane Database Syst Rev. 2014;2014(8):CD003641. Published 2014 Aug 8.

National Institutes of Health and Care Excellence (NICE); Obesity: identification, assessment and management Clinical guideline [CG189] Published: 27 November 2014

https://www.nice.org.uk/guidance/cg189/chapter/1-Recommendations#surgical-interventions

Chang SH, Stoll CR, Song J, Varela JE, Eagon CJ, Colditz GA. The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003-2012. JAMA Surg. 2014;149(3):275-287.

Burgos AM, Braghetto I, Csendes A, Maluenda F, Korn O, Yarmuch J, Gutierrez L. Gastric leak after laparoscopic-sleeve gastrectomy for obesity. Obes Surg. 2009 Dec;19(12):1672-7.

Fielding GA, Allen JW. A step-by-step guide to placement of the LAP-BAND adjustable gastric banding system. Am J Surg. 2002 Dec;184(6B):26S-30S.

Longitudinal Assessment of Bariatric Surgery (LABS) Consortium, Flum DR, Belle SH, et al. Perioperative safety in the longitudinal assessment of bariatric surgery. N Engl J Med. 2009;361(5):445-454.

Sartori A, De Luca M, Clemente N, Lunardi C, Segato G, Pellicano N. Complications of laparoscopic gastric banding: detection and treatment. Ann Ital Chir. 2017;88:206-214.

Higa KD, Boone KB, Ho T, Davies OG. Laparoscopic Roux-en-Y gastric bypass for morbid obesity: technique and preliminary results of our first 400 patients. Arch Surg 2000;135:1029–33;discussion 1033.

Puzziferri, N., Roshek, T. B., 3rd, Mayo, H. G., Gallagher, R., Belle, S. H., & Livingston, E. H. (2014). Long-term follow-up after bariatric surgery: a systematic review. JAMA, 312(9), 934–942.

Biertho L, Lebel S, Marceau S, Hould FS, Julien F, Biron S. Biliopancreatic Diversion with Duodenal Switch: Surgical Technique and Perioperative Care. Surg Clin North Am. 2016 Aug;96(4):815-26.

Buchwald H, Estok R, Fahrbach K, Banel D, Jensen MD, Pories WJ, Bantle JP, Sledge I. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med. 2009 Mar;122(3):248-256.e5.

Conner J, Nottingham JM. Biliopancreatic Diversion With Duodenal Switch. 2021 Sep 20. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–.

Jabbour, Georges, and Ahmad Salman. “Bariatric Surgery in Adults with Obesity: the Impact on Performance, Metabolism, and Health Indices.” Obesity surgery vol. 31,4 (2021): 1767-1789.

Gloy, V. L., Briel, M., Bhatt, D. L., Kashyap, S. R., Schauer, P. R., Mingrone, G., Bucher, H. C., & Nordmann, A. J. (2013). Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials. BMJ (Clinical research ed.), 347, f5934.

Velapati SR, Shah M, Kuchkuntla AR, Abu-Dayyeh B, Grothe K, Hurt RT, Mundi MS. Weight Regain After Bariatric Surgery: Prevalence, Etiology, and Treatment. Curr Nutr Rep. 2018 Dec;7(4):329-334.

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Published

2022-05-11

How to Cite

1.
OSIAK, Joanna, MIKUT, Karolina, WIJATA, Aleksandra & KĘDZIORA-KORNATOWSKA, Kornelia. Obesity treatment - overview of pharmacological and surgical methods. Journal of Education, Health and Sport [online]. 11 May 2022, T. 12, nr 7, s. 40–48. [accessed 29.3.2023]. DOI 10.12775/JEHS.2022.12.07.005.
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Vol. 12 No. 7 (2022)

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Review Articles

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Copyright (c) 2022 Joanna Osiak, Karolina Mikut, Aleksandra Wijata, Kornelia Kędziora-Kornatowska

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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