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Journal of Education, Health and Sport

The experience of using ACE inhibitors and Ca channel blockers in the treatment of hypertension in patients with renal cell carcinoma
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The experience of using ACE inhibitors and Ca channel blockers in the treatment of hypertension in patients with renal cell carcinoma

Authors

  • Serhii Pasichnyk Danylo Halytsky Lviv National Medical University
  • Anatolii Gozhenko Ukrainian Research Institute of Transport Medicine of the MoH of Ukraine

DOI:

https://doi.org/10.12775/JEHS.2022.12.02.027

Keywords

renal cell carcinoma, hypertension, kidney cancer

Abstract

Renal cell carcinoma (RCC) is one of widely spread urological cancers. It is known that approximately 26% of patients with a history of kidney cancer (KC) may have concomitant coronary artery disease, hypertension, diabetes mellitus and some other systemic diseases, which may lead to nephrosclerotic changes and the development or progression of the existing CRF.

The aim of the study. To study the renal function effects of ACE inhibitors (perindopril arginine) in patients with RCC, both as monotherapy and in combination with Ca channel blockers when conducting treatment of concomitant hypertension (HT).

Materials and methods. The study enrolled 38 patients with RCC. All patients were diagnosed with RCC for the first time, with their cancer staged according to the TNM International Classification (Т1 N0 M0).

Within a month, the use of combination therapy for kidney cancer complicated by Stage І, Degree ІІ hypertension was leading to increases in serum creatinine by 3 µmol/l and by 7 µmol/l in those patients where combination therapy was not used. In the meantime, during the same period, glomerular filtration rate reduced by 5 ml/min/1.73 m2 in patients of the first group and by 15 ml/min/1.73 m2 in patients of the second group.

References

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Relationship between hemoglobin level and quality of life in anemic patients with chronic kidney disease receiving epoetin alfa / P. Lefebvre, F. Vekeman, B. Sarokhan et al. Curr. Med. Res. Opin. 2006. Vol. 22, No. 10. Р. 1929-1937.

Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy / Sabatino M., Kim-Schulze S., Panelli M. C. et al. J. Clin. Oncol. 2009. Vol. 27, No. 16. Р. 2645-2652.

Skorupska E., Samborski W. Fizykoterapia w chorobach reumatycznych . Wielka Interna. Reumatologia / ed. Puszczewicz M. Warszawa: Medical Tribune, 2016. S. 515-522.

The health consequence of smoking: a report of the surgeon general / Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health. Washington, D. C., 2004. Р. 1-20.

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Published

2022-02-28

How to Cite

1.
PASICHNYK, Serhii & GOZHENKO, Anatolii. The experience of using ACE inhibitors and Ca channel blockers in the treatment of hypertension in patients with renal cell carcinoma. Journal of Education, Health and Sport [online]. 28 February 2022, T. 12, nr 2, s. 255–261. [accessed 21.3.2023]. DOI 10.12775/JEHS.2022.12.02.027.
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Issue

Vol. 12 No. 2 (2022)

Section

Research Articles

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Copyright (c) 2022 Serhii Pasichnyk, Anatolii Gozhenko

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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