The relation between adipose-derived stem cells and wound healing process - the review
DOI:
https://doi.org/10.12775/JEHS.2022.12.04.007Keywords
adipose tissue, stem cells, regeneration, wound healingAbstract
Introduction and purpose: Wound healing is a process including complex overlapping stages requiring many components. Adipose tissue is an organ that is responsible for maintaining homeostasis through inflammatory responses, signal transmission, energy expenditure connected with different organs. Fat tissue is a rich and readily available source of multipotent stem cells. Adipose-derived stem cells (ADSCs) have the potential in tissue regeneration because of their self-renewal and ability to differentiate in various types of cells. This review discusses ADSCs in terms of basic knowledge, methods of acquisition, prospects for use in healthcare, focusing mainly on the potential application in the wound healing process.
Brief description of the state of knowledge: The article contains current knowledge about biology, specific properties of adipose-derived stem cells and also shows the relationship to the wound healing process. The review presents research that points to the possibility of using ADSCs in future medicine.
Conclusions: Adipose-derived stem cells may constitute a prominent role in tissue regeneration owing to the secretion of various cytokines, the ability to differentiate into multiple lineages, their immunomodulatory effects, and the ease of cell obtaining. Further studies are required to explore the accurate mechanism of ADSCs action and their long-term safety in clinical application. Stem cell therapy brings new hope for the repair of chronic and refractory wounds and skin defects.
References
P. H. Wang, B. S. Huang, H. C. Horng, C. C. Yeh, and Y. J. Chen, “Wound healing,” Journal of the Chinese Medical Association, vol. 81, no. 2. Elsevier Ltd, pp. 94–101, Feb. 01, 2018, doi: 10.1016/j.jcma.2017.11.002.
L. Rittié, “Cellular mechanisms of skin repair in humans and other mammals,” J. Cell Commun. Signal., vol. 10, no. 2, p. 103, Jun. 2016, doi: 10.1007/S12079-016-0330-1.
Z. Q. Zhou et al., “Adipose extracellular matrix promotes skin wound healing by inducing the differentiation of adipose-derived stem cells into fibroblasts,” Int. J. Mol. Med., vol. 43, no. 2, p. 890, Feb. 2019, doi: 10.3892/IJMM.2018.4006.
G. Han and R. Ceilley, “Chronic Wound Healing: A Review of Current Management and Treatments,” Adv. Ther., vol. 34, no. 3, p. 599, Mar. 2017, doi: 10.1007/S12325-017-0478-Y.
A. Ritter et al., “Subcutaneous and Visceral Adipose-Derived Mesenchymal Stem Cells: Commonality and Diversity,” Cells, vol. 8, no. 10, Oct. 2019, doi: 10.3390/CELLS8101288.
S. S. Sharath, J. Ramu, S. V. Nair, S. Iyer, U. Mony, and J. Rangasamy, “Human Adipose Tissue Derivatives as a Potent Native Biomaterial for Tissue Regenerative Therapies,” Tissue Eng. Regen. Med., vol. 17, no. 2, p. 123, Apr. 2020, doi: 10.1007/S13770-019-00230-X.
C. L. Franck, A. C. Senegaglia, L. M. B. Leite, S. A. B. De Moura, N. F. Francisco, and J. M. Ribas Filho, “Influence of Adipose Tissue-Derived Stem Cells on the Burn Wound Healing Process,” Stem Cells Int., vol. 2019, 2019, doi: 10.1155/2019/2340725.
W. Zakrzewski, M. Dobrzyński, M. Szymonowicz, and Z. Rybak, “Stem cells: past, present, and future,” Stem Cell Res. Ther., vol. 10, no. 1, Feb. 2019, doi: 10.1186/S13287-019-1165-5.
G. Kolios and Y. Moodley, “Introduction to Stem Cells and Regenerative Medicine,” Respiration, vol. 85, no. 1, pp. 3–10, Dec. 2013, doi: 10.1159/000345615.
A. Trzyna and A. Banaś-Ząbczyk, “Adipose-Derived Stem Cells Secretome and Its Potential Application in ‘Stem Cell-Free Therapy,’” Biomolecules, vol. 11, no. 6, Jun. 2021, doi: 10.3390/BIOM11060878.
M. Rodbell, “Metabolism of Isolated Fat Cells: II. THE SIMILAR EFFECTS OF PHOSPHOLIPASE C (CLOSTRIDIUM PERFRINGENS α TOXIN) AND OF INSULIN ON GLUCOSE AND AMINO ACID METABOLISM,” J. Biol. Chem., vol. 241, no. 1, pp. 130–139, Jan. 1966, doi: 10.1016/S0021-9258(18)96967-X.
P. A. Zuk et al., “Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies,” https://home.liebertpub.com/ten, vol. 7, no. 2, pp. 211–228, Jul. 2004, doi: 10.1089/107632701300062859.
A. S. Klar, J. Zimoch, and T. Biedermann, “Skin Tissue Engineering: Application of Adipose-Derived Stem Cells,” BioMed Research International, vol. 2017. Hindawi Limited, 2017, doi: 10.1155/2017/9747010.
S. Shin, A. S. El-Sabbagh, B. E. Lukas, S. J. Tanneberger, and Y. Jiang, “Adipose stem cells in obesity: challenges and opportunities,” Biosci. Rep., vol. 40, no. 6, Jun. 2020, doi: 10.1042/BSR20194076.
L. V. Trevor, K. Riches-Suman, A. L. Mahajan, and M. J. Thornton, “Adipose Tissue: A Source of Stem Cells with Potential for Regenerative Therapies for Wound Healing,” J. Clin. Med., vol. 9, no. 7, pp. 1–14, Jul. 2020, doi: 10.3390/JCM9072161.
Z. Si et al., “Adipose-derived stem cells: Sources, potency, and implications for regenerative therapies,” Biomed. Pharmacother., vol. 114, p. 108765, Jun. 2019, doi: 10.1016/J.BIOPHA.2019.108765.
S. Kern, H. Eichler, J. Stoeve, H. Kl¨uter, K. Kl¨uter, and K. Bieback, “Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue,” Stem Cells, vol. 24, no. 5, pp. 1294–1301, May 2006, doi: 10.1634/STEMCELLS.2005-0342.
M. Xiong et al., “Exosomes From Adipose-Derived Stem Cells: The Emerging Roles and Applications in Tissue Regeneration of Plastic and Cosmetic Surgery,” Front. Cell Dev. Biol., vol. 8, p. 574223, Sep. 2020, doi: 10.3389/FCELL.2020.574223.
A. Schäffler, C. Büchler, A. S. Sch¨affler, and C. B¨uchlerb¨uchler, “Concise Review: Adipose Tissue-Derived Stromal Cells—Basic and Clinical Implications for Novel Cell-Based Therapies,” Stem Cells, vol. 25, no. 4, pp. 818–827, Apr. 2007, doi: 10.1634/STEMCELLS.2006-0589.
J. A. van Dongen, M. C. Harmsen, B. van der Lei, and H. P. Stevens, “Augmentation of Dermal Wound Healing by Adipose Tissue-Derived Stromal Cells (ASC),” Bioengineering, vol. 5, no. 4, Dec. 2018, doi: 10.3390/BIOENGINEERING5040091.
H. Lawall, P. Bramlage, and B. Amann, “Stem cell and progenitor cell therapy in peripheral artery disease: A critical appraisal,” Thromb. Haemost., vol. 103, no. 4, pp. 696–709, Apr. 2010, doi: 10.1160/TH09-10-0688/ID/JR0688-11.
L. Mazini, L. Rochette, B. Admou, S. Amal, and G. Malka, “Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing,” Int. J. Mol. Sci., vol. 21, no. 4, Feb. 2020, doi: 10.3390/IJMS21041306.
W. S. Kim et al., “Evidence supporting antioxidant action of adipose-derived stem cells: Protection of human dermal fibroblasts from oxidative stress,” J. Dermatol. Sci., vol. 49, no. 2, pp. 133–142, Feb. 2008, doi: 10.1016/J.JDERMSCI.2007.08.004.
R. C. Rennert, M. Sorkin, R. K. Garg, and G. C. Gurtner, “Stem cell recruitment after injury: lessons for regenerative medicine,” Regen. Med., vol. 7, no. 6, p. 833, Nov. 2012, doi: 10.2217/RME.12.82.
F. Ji, Y. Wang, J. Yuan, Q. Wu, J. Wang, and D. Liu, “The potential role of stromal cell-derived factor-1α/CXCR4/CXCR7 axis in adipose-derived mesenchymal stem cells,” J. Cell. Physiol., vol. 235, no. 4, pp. 3548–3557, Apr. 2020, doi: 10.1002/JCP.29243.
Q. Wu, F. K. Ji, J. H. Wang, H. Nan, and D. L. Liu, “Stromal cell-derived factor 1 promoted migration of adipose-derived stem cells to the wounded area in traumatic rats,” Biochem. Biophys. Res. Commun., vol. 467, no. 1, pp. 140–145, Nov. 2015, doi: 10.1016/J.BBRC.2015.09.097.
A. Barzelay et al., “Adipose-Derived Mesenchymal Stem Cells Migrate and Rescue RPE in the Setting of Oxidative Stress,” Stem Cells Int., vol. 2018, 2018, doi: 10.1155/2018/9682856.
N. Naderi et al., “The regenerative role of adipose‐derived stem cells (ADSC) in plastic and reconstructive surgery,” Int. Wound J., vol. 14, no. 1, p. 112, Feb. 2017, doi: 10.1111/IWJ.12569.
L. Hu et al., “Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts,” Sci. Rep., vol. 6, Sep. 2016, doi: 10.1038/SREP32993.
H. Mizuno, M. Tobita, and A. C. Uysal, “Concise Review: Adipose‐Derived Stem Cells as a Novel Tool for Future Regenerative Medicine,” Stem Cells, vol. 30, no. 5, pp. 804–810, May 2012, doi: 10.1002/STEM.1076.
A. da F. Ferreira and D. A. Gomes, “Stem Cell Extracellular Vesicles in Skin Repair,” Bioengineering, vol. 6, no. 1, Jan. 2019, doi: 10.3390/BIOENGINEERING6010004.
J. Luck, O. J. Smith, D. Malik, and A. Mosahebi, “Protocol for a systematic review of autologous fat grafting for wound healing,” Syst. Rev., vol. 7, no. 1, Jul. 2018, doi: 10.1186/S13643-018-0769-7.
R. Yañez et al., “Adipose Tissue‐Derived Mesenchymal Stem Cells Have In Vivo Immunosuppressive Properties Applicable for the Control of the Graft‐Versus‐Host Disease,” Stem Cells, vol. 24, no. 11, pp. 2582–2591, Nov. 2006, doi: 10.1634/STEMCELLS.2006-0228.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Dariusz Gruca, Marlena Zając, Wiktor Wróblewski, Monika Borowiecka, Dagmara Buksak
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 441
Number of citations: 0
