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Journal of Education, Health and Sport

Eslicarbazepine acetate: An efficacy and safety as an antiepileptic drug in clinical trials and open studies
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  • Eslicarbazepine acetate: An efficacy and safety as an antiepileptic drug in clinical trials and open studies
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  3. Vol. 12 No. 2 (2022) /
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Eslicarbazepine acetate: An efficacy and safety as an antiepileptic drug in clinical trials and open studies

Authors

  • Martyna Stefaniak Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0002-8036-8379
  • Zofia Pietrzak Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0001-8469-6225
  • Piotr Dzikowski Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0002-6335-9171
  • Emilia Nowicka Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0002-2743-1551
  • Michał Obel Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0003-1237-8732
  • Halina Piecewicz-Szczęsna Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0002-0573-7226

DOI:

https://doi.org/10.12775/JEHS.2022.12.02.002

Keywords

Eslicarbazepine acetate, Focal-onset seizures, Monotherapy, Adjunctive therapy

Abstract

Eslicarbazepine acetate (Zebinix®, ESL), a voltage-gated sodium channel blocker, is a once-daily, orally administered anti-seizure medication available in the EU for use as monotherapy in adults with newly diagnosed partial-onset seizures and as adjunctive therapy in adults, adolescents, and children aged > 6 years with partial-onset seizures. It was approved by the European Medicines Agency and launched onto the European market in 2009.

This study aimed to assess the efficacy and safety of ESL in the treatment of focal-onset seizures. Our study material consisted of publications, which were found in PubMed, Google Scholar, and Embase databases. In order to find the proper publications, the search has been conducted with the use of a combination of keywords like: “eslicarbazepine acetate", "focal-onset seizures treatment", "epilepsy treatment", "eslicarbazepine acetate pharmacokinetics”. The first step was to find proper publications from the last 10 years. The second step was to carry out an overview of the found publications.

Results of mentioned studies proved that for adults with medically uncontrolled partial-onset seizures, ESL monotherapy is well tolerated and effective over the long term, including the patients who transitioned from CBZ-CR monotherapy. Adjunctive ESL demonstrated a sustained therapeutic effect and was well-tolerated, safe, and efficacious during the treatment of adults with partial-onset seizures. Both 800 mg and 1200 mg once-daily doses were well tolerated. Moreover, significant improvements in depressive symptoms and quality of life domains were observed under long-term treatment with ESL.

References

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Vaz-Da-Silva M, Nunes T, Almeida L, Gutierrez MJ, Litwin JS, Soares-Da-Silva P. Evaluation of Eslicarbazepine acetate on cardiac repolarization in a thorough QT/QTc study. J Clin Pharmacol. 2012 Feb;52(2):222-33. doi: 10.1177/0091270010391789. PMID: 21415284.

Mintzer S, Wechsler RT, Rogin JB, Gidal BE, Schwab M, Ben-Menachem E, Carreño M, da Silva PS, Moreira J, Li Y, Blum D, Grinnell T. Effects of adjunctive eslicarbazepine acetate on serum lipids in patients with partial-onset seizures: Impact of concomitant statins and enzyme-inducing antiepileptic drugs. Epilepsy Res. 2018 Mar;141:83-89. doi: 10.1016/j.eplepsyres.2018.02.001. Epub 2018 Feb 9. PMID: 29499473.

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Published

2022-02-02

How to Cite

1.
STEFANIAK, Martyna, PIETRZAK, Zofia, DZIKOWSKI, Piotr, NOWICKA, Emilia, OBEL, Michał and PIECEWICZ-SZCZĘSNA, Halina. Eslicarbazepine acetate: An efficacy and safety as an antiepileptic drug in clinical trials and open studies. Journal of Education, Health and Sport. Online. 2 February 2022. Vol. 12, no. 2, pp. 16-26. [Accessed 4 July 2025]. DOI 10.12775/JEHS.2022.12.02.002.
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Vol. 12 No. 2 (2022)

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Review Articles

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Copyright (c) 2022 Martyna Stefaniak, Zofia Pietrzak, Piotr Dzikowski, Emilia Nowicka, Michał Obel, Halina Piecewicz-Szczęsna

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