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Journal of Education, Health and Sport

Autoimmune pituitary inflammation
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Autoimmune pituitary inflammation

Authors

  • Szymon Krzewski Chair and Department of Pedodontics, Medical University of Lublin https://orcid.org/0000-0003-2339-6741
  • Mateusz Baranowski Medical University of Lublin, Chair and Department of Periodontology https://orcid.org/0000-0001-7266-738X
  • Katarzyna Wzorek Department of Radiation Therapy, Independent Public Clinical Hospital No.1 in Lublin https://orcid.org/0000-0003-1873-0629

DOI:

https://doi.org/10.12775/JEHS.2022.12.02.001

Keywords

pituitary gland, autoimmune diseases, autoimmune pituitary inflammation

Abstract

Autoimmune Hypophysitis (AH) is often refereed in the literature as lymphocytic pituitary inflammation. It is the most common form of rare, chronic inflammation states affecting this gland. In most cases it has autoimmune character. Symptoms of pituitary inflammation are mostly headaches, dysfunction of anterior and/or posterior pituitary lobe and visual disturbances. Diagnostics is extremely difficult and inflammation itself is probably diagnosed too rare. Autoimmune Hypophysitis coexist with other autoimmune endocrinopathies. The golden standard in Autoimmune Hypophysitis diagnosis is biopsy and magnetic resonance imaging (MRI) is also used. In relation to rare occurrence of the  Autoimmune Hypophysitis, varied clinical picture and lack of standardized research on large group of patients there are no described standards of conduct with those patients.

Author Biography

Mateusz Baranowski, Medical University of Lublin, Chair and Department of Periodontology

PHD Student, Dentist,  Chair and Department of Periodontology

References

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Bellastella G, Maiorino MI, Bizzarro A, Giugliano D, Esposito K, Bellastella A, et al. Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects. Pituitary. 2016 Dec;19(6):625–42.

Langlois F, Varlamov EV, Fleseriu M. Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease. J Clin Endocrinol Metab. 2022 Jan 1;107(1):10–28.

de Vries F, van Furth WR, Biermasz NR, Pereira AM. Hypophysitis: A comprehensive overview. Presse Médicale. 2021 Dec;50(4):104076.

Caturegli P, Newschaffer C, Olivi A, Pomper MG, Burger PC, Rose NR. Autoimmune Hypophysitis. Endocr Rev. 2005;26(5):599–614.

De Bellis A, Bizzarro A, Bellastella A. Pituitary antibodies and lymphocytic hypophysitis. Best Pract Res Clin Endocrinol Metab. 2005;19(1):67–84.

Hashimoto K, Takao T, Makino S. Lymphocytic adenohypophysitis and lymphocytic infundibuloneurohypophysitis. Endocr J. 1997;44(1):1–10.

Bellastella A, Bizzarro A, Coronella C, Bellastella G, Sinisi AA, De Bellis A. Lymphocytic hypophysitis: a rare or underestimated disease? Eur J Endocrinol. 2003;149(5):363–76.

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De Bellis A, Bizzarro A, Conte M, Perrino S, Coronella C, Solimeno S, et al. Antipituitary antibodies in adults with apparently idiopathic growth hormone deficiency and in adults with autoimmune endocrine diseases. J Clin Endocrinol Metab. 2003;88(2):650–4.

Nishino M, Yabe S, Murakami M, Kanda T, Kobayashi I. Detection of antipituitary antibodies in patients with autoimmune thyroid disease. Endocr J. 2001;48(2):185–91.

O’Dwyer DT, Clifton V, Hall A, Smith R, Robinson PJ, Crock PA. Pituitary autoantibodies in lymphocytic hypophysitis target both γ- and α-Enolase – a link with pregnancy? Arch Physiol Biochem. 2002;110(1–2):94–8.

Krysiak R, Okopień B, Herman ZS. Zapalenie przysadki mózgowej. Przegląd Lek. 2007;64(515–20):7–8.

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Published

2022-02-02

How to Cite

1.
KRZEWSKI, Szymon, BARANOWSKI, Mateusz and WZOREK, Katarzyna. Autoimmune pituitary inflammation. Journal of Education, Health and Sport. Online. 2 February 2022. Vol. 12, no. 2, pp. 11-15. [Accessed 17 May 2025]. DOI 10.12775/JEHS.2022.12.02.001.
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Issue

Vol. 12 No. 2 (2022)

Section

Review Articles

License

Copyright (c) 2022 Szymon Krzewski, Mateusz Baranowski, Katarzyna Wzorek

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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