Relationships between geomagnetic Ар-indeх and EEG parameters in patients with dysfunction of the neuroendocrine-immune complex
DOI:
https://doi.org/10.12775/JEHS.2021.11.08.060Keywords
geomagnetic Ap-index, acupuncture points, EEG, immunity, relationships, humansAbstract
Background. Recently, on the example of two cohort of patients, we found that disturbances of the geomagnetic field cause a significant immediate modulating effect on the level of immune parameters in the blood. The data available in the literature give grounds for assumptions about the direct effect of disturbances of the geomagnetic field on immunocytes, and indirectly, through immunotropic neurotransmitters and hormones. Our hypothesis is as follows. Disturbances of the geomagnetic field are perceived by acupuncture points (APs). The information obtained is transmitted to neurons and endocrinocytes, the mediators of which, in turn, affect immunocytes. The purpose of this study is to test this hypothesis.
Methods. The object of observation were 21 men (24-63 y) and 20 women (30-72 y) with neuroendocrine-immune complex dysfunction. Each patient was tested twice with an interval of 4 days. We recorded the ongoing electroencephalogram (EEG). Retrospectively we recorded the geomagnetic Ap-Index on the day of testing and during the previous 7 days, using resource https://www.spaceweatherlive.com/.
Results. The canonical correlation between Ap-indices for 7 days before and on the day of testing, and EEG parameters is 0,886; immunity parameters is 0,921. In turn, the immune parameters are closely related to the EEG parameters (R=0,944).
Conclusion. Disturbances of the geomagnetic field (Ap-index) causes a significant immediate modulating effect on the parameters of immunity as well as EEG, apparently through acupuncture points as polymodal receptors of the ecoceptive sensitivity system.
References
Popovych IL, Gozhenko AI, Badiuk NS, Napierata M, Muszkieta R, Zukow W, Yanchij RI, Lapovets’ NYe, Lapovets’ LYe, Tserkovniuk RG, Akimova VM, Nahurna YV, Martianova OI, Vivchar RYa, Chendey IV, Ruzhylo SV. Relationships between geomagnetic Ар-indeх and parameters of the immunity in patients with multiple sclerosis and radiculopathies. Journal of Education, Health and Sport. 2021; 11(3): 77-90.
Tserkovniuk R, Yanchij R, Plyska O, Kovbasnyuk M, Chendey I, Hagner-Derengowska M, Zukow X, Kałuzny K, Muskieta R, Zukow W. Relationships between geomagnetic Ар-indeх and parameters of the immunity in patients with neuroendocrine-immune complex dysfunction. PharmacologyOnLine. 2021; 3: .
Limansky YuP. Hypothesis about acupuncture points as polymodal receptors of the ecoceptive sensitivity system. Fiziol Zhurn. 1990; 36(4): 115-121. [in Russian].
Gulyar SA, Limansky YuP. Functional system of regulation of electromagnetic balance of organism: mechanisms of primary reception of electromagnetic waves of optical range. Fiziol Zhurn. 2003; 49(2): 35-44. [in Ukrainian].
Popadynets’ OO, Gozhenko AI, Zukow W, Popovych IL. Peculiarities of spectral parameters of EEG, HRV and routine parameters of immunity in patients with various levels of the entropy of EEG, HRV, immunocytogram and leukocytogram. Journal of Education, Health and Sport. 2019; 9(8): 617-636.
Popadynets’ O, Gozhenko A, Badyuk N, Popovych I, Skaliy A, Hagner-Derengowska M, et al. Interpersonal differences caused by adaptogen changes in entropies of EEG, HRV, immunocytogram, and leukocytogram. Journal of Physical Education and Sport. 2020; 20(Suppl. 2): 982-999.
Gozhenko АІ, Korda MM, Popadynets’ OO, Popovych IL. Entropy, Harmony, Synchronization and their Neuro-endocrine-immune Correlates. Odesa. Feniks; 2021: 232. [in Ukrainian].
Muehsam D, Ventura C. Life rhythm as a symphony of oscillatory patterns: electromagnetic energy and sound vibration modulates gene expression for biological signaling and healing. Glob Adv Health Med. 2014; 3(2): 40-55. doi:10.7453/gahmj.2014.008.
Babayev ES, Allahverdiyeva AA. Effects of geomagnetic activity variations on the physiological and psychological state of functionally healthy humans: some of results of the Azerbijani studies. Advances in Space Research. 2007; 40: 1941–1951.
Mulligan BP, Hunter MD, Persinger MA. Effects of geomagnetic activity and atmospheric power variations on quantitative measures of brain activity: replication of the Azerbaijani studies. Advances in Space Research. 2010; 45: 940–948.
Novik OB, Smirnov FA. Geomagnetic storm decreases coherence of electric oscillations of human brain while working at the computer. Biofizika. 2013;58(3):554-560.
Baevsky RM, Petrov VM, Cornelissen G, Halberg F, Orth-Gomer K, Akerstedt T, Otsuka K, Breus T, Siegelova J, Dusek J, Fiser B. Meta-analyzed heart rate variability, exposure to geomagnetic storms, and the risk of ischemic heart disease. Scr Med (Brno). 1997; 70(4–5): 201–206.
McCraty R, Atkinson M, Stolc V, Alabdulgader AA, Vainoras A, Ragulskis M. Synchronization of Human Autonomic Nervous System Rhythms with Geomagnetic Activity in Human Subjects. International journal of environmental research and public health. 2017; 14(7): 770. https://doi.org/10.3390/ijerph14070770
Persinger MA, Richards PM. Vestibular experiences of humans during brief periods of partial sensory deprivation are enhanced when daily geomagnetic activity exceeds 15–20 nT. Neuroscience Letters. 1995; 194: 69–72.
Cherry N. Schumann resonance, a plausible biophysical mechanism for the human health effects of solar/geomagnetic activity. Natural Hazards. 2002; 26: 279–331.
Schlegel K, Fuellekrug K. Schumann resonance parameter changesduring high-energy particle precipitation. Journal of Geophysical Research. 1999; 104(10):111–110.
Koenig HL, Krueger AP, Lang S, Sonning W. Biologic Effects of Environmental Electromagnetism. Springer-Verlag, New York, 1981.
Buzsaki G. Theta oscillations in the hippocampus. Neuron. 2002; 33:325–340,.
Gloor P. The Temporal Lobe and Limbic System. Oxford, New York,1997.
Benarroch EE. The central autonomic network: functional organization, dysfunction, and perspective. Mayo Clin Proc. 1993;68(10):988-1001. doi:10.1016/s0025-6196(12)62272-1
Palma JA, Benarroch EE. Neural control of the heart: recent concepts and clinical correlations. Neurology. 2014; 83: 261–271.doi: 10.1212/WNL.0000000000000605
Thayer JF, Lane RD. Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration. Neurosci Biobehav Rev. 2009;33(2):81-88. doi:10.1016/j.neubiorev.2008.08.004
Verberne AJ. Medullary sympathoexcitatory neurons are inhibited by activation of the medial prefrontal cortex in the rat. Am J Physiol. 1996;270(4Pt2):R713-R719. doi:10.1152/ajpregu. 1996.270.4.R713
Verberne AJ, Lam W, Owens NC, Sartor D. Supramedullary modulation of sympathetic vasomotor function. Clin Exp Pharmacol Physiol. 1997;24(9-10):748-754. doi:10.1111/j.1440-1681.1997.tb02126.x
Guo CC, Sturm VE, Zhou J, Gennatas ED, Trujillo AJ, Hua AY, et al. Dominant hemisphere lateralization of cortical parasympathetic control as revealed by frontotemporal dementia. Proc Natl Acad Sci USA. 2016;113:E2430–E2439. doi: 10.1073/pnas.1509184113.
Winkelmann T, Thayer JF, Pohlack S, Nees F, Grimm O, Flor H. Structural brain correlates of heart rate variability in a healthy young adult population. Brain Struct Funct. 2017;222(2):1061-1068. doi:10.1007/s00429-016-1185-1
Thayer J F, Ǻhs F, Fredrikson M, Sollers JJ III, Wager TD. A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neurosci Biobehav Rev. 2012;36:747–756. doi: 10.1016/j.neubiorev.2011.11.009
Yoo HJ, Thayer JF, Greening S, Lee T-H, Ponzio A, Min J, Sakaki M, Nga L, Mather M, Koeniget J. Brain structural concomitants of resting state heart rate variability in the young and old: evidence from two independent samples. Brain Struct Funct. 2018;223(2):727-737. doi:10.1007/s00429-017-1519-7
Carnevali L, Koenig J, Sgoifo A, Ottaviani C. Autonomic and Brain Morphological Predictors of Stress Resilience Front Neurosci. 2018; 12: 228.
Ho MW, Knight DP. The acupuncture system and the liquid crystalline collagen fibers of the connective tissues. Am J Chin Med. 1998;26(3-4):251-263.
Langevin HM. Connective tissue: a body-wide signaling network? Med Hypotheses. 2006;66(6):1074-1077.
Tracey KJ. Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest. 2007; 117(2): 289-296.
Thayer JF, Sternberg EM. Neural aspects of immunomodulation: Focus on the vagus nerve. Brain Behav Immun. 2010; 24(8): 1223-1228.
Popovych IL, Lukovych YuS, Korolyshyn TA, Barylyak LG, Kovalska LB, Zukow W. Relationship between the parameters heart rate variability and background EEG activity in healthy men. Journal of Health Sciences. 2013; 3(4): 217-240.
Popovych IL, Kozyavkina OV, Kozyavkina NV, Korolyshyn TA, Lukovych YuS, Barylyak LG. Correlation between Indices of the Heart Rate Variability and Parameters of Ongoing EEG in Patients Suffering from Chronic Renal Pathology. Neurophysiology. 2014; 46(2): 139-148.
Kul’chyns’kyi AB, Kovbasnyuk MM, Kyjenko VM., Zukow W, Popovych IL. Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 2. Correlations between parameters EEG, HRV and Phagocytosis. Journal of Education, Health and Sport. 2016; 6(10): 377-401.
Kul’chyns’kyi AB, Gozhenko AI, Zukow W, Popovych IL. Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 3. Correlations between parameters EEG, HRV and Immunogram. Journal of Education, Health and Sport. 2017; 7(3): 53-71.
Kul’chyns’kyi AB, Kyjenko VM, Zukow W, Popovych IL. Causal neuro-immune relationships at patients with chronic pyelonephritis and cholecystitis. Correlations between parameters EEG, HRV and white blood cell count. Open Medicine. 2017; 12(1): 201-213.
Kul’chyns’kyi AB, Zukow W, Korolyshyn TA, Popovych IL. Interrelations between changes in parameters of HRV, EEG and humoral immunity at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2017; 7(9): 439-459.
Popovych IL, Kul’chyns’kyi AB, Korolyshyn TA, Zukow W. Interrelations between changes in parameters of HRV, EEG and cellular immunity at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2017; 7(10): 11-23.
Popovych IL, Kul’chyns’kyi AB, Gozhenko AI, Zukow W, Kovbasnyuk MM, Korolyshyn TA. Interrelations between changes in parameters of HRV, EEG and phagocytosis at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2018; 8(2): 135-156.
Gozhenko AI, Zukow W, Polovynko IS, Zajats LM, Yanchij RI, Portnichenko VI, Popovych IL. Individual Immune Responses to Chronic Stress and their Neuro-Endocrine Accompaniment. RSW. UMK. Radom. Torun; 2019: 200.
Nordmann GC, Hochstoeger T, Keays DA. Unsolved mysteries: magnetoreception - A sense without a receptor. PLoS Biol. 2017;15(10): e2003234.
Gegear RJ, Casselman A, Waddell S, Reppert SM. Cryptochrome mediates light-dependent magnetosensitivity in Drosophila. Nature. 2008;454(7207):1014–1018. https://doi.org/10.1038/nature07183
Foley L, Gegear R, Reppert S. Human cryptochrome exhibits light-dependent magnetosensitivity. Nat Commun. 2011;2:356. https://doi.org/10.1038/ncomms1364
Zaporozhan V, Ponomarenko A. Mechanisms of geomagnetic field influence on gene expression using influenza as a model system: basics of physical epidemiology. Int J Environ Res Public Health. 2010;7(3):938-965. doi:10.3390/ijerph7030938.
Hammad M, Albaqami M, Pooam M, Kernevez E, Witczak J, Ritz T, Martino C, Ahmad M. Cryptochrome mediated magnetic sensitivity in Arabidopsis occurs independently of light-induced electron transfer to the flavin. Photochemical Photobiological Sciences. 2020;19(3): 341–352. https://doi.org/10.1039/c9pp00469f
Cifra M, Apollonio F, Liberti M, García-Sánchez T, Mir LM. Possible molecular and cellular mechanisms at the basis of atmospheric electromagnetic field bioeffects. International journal of biometeorology. 2021; 65(1):59–67. https://doi.org/10.1007/s00484-020-01885-1
Wan G, Hayden AN, Iiams SE, Merlin C. Cryptochrome 1 mediates light-dependent inclination magnetosensing in monarch butterflies. Nature communications. 2021;12(1):771. https://doi.org/10.1038/s41467-021-21002-z
Kirschvink JL, Kobayashi-Kirschvink A, Woodford BJ. Magnetite biomineralization in the human brain. Proc Natl Acad Sci USA. 1992;89(16):7683–7687. doi: 10.1073 /pnas.89. 16. 7683.
Kirschvink JL, Kobayashi-Kirschvink A, Diaz-Ricci JC, Kirschvink SJ. Magnetite in human tissues: a mechanism for the biological effects of weak ELF magnetic fields. Bioelectromagnetics. 1992; Suppl 1: 101–113.
Kirschvink JL, Walker MM, Diebel CE. Magnetite-based magnetoreception. Curr Opin Neurobiol. 2001;11(4):462–467.
Winklhofer M, Kirschvink JL. A quantitative assessment of torque-transducer models for magnetoreception. JRSocInterface. 2010;7(suppl_2):S273–S289.
Gilder SA, Wack M, Kaub L, Roud SC, Petersen N, Heinsen H, et al. Distribution of magnetic remanence carriers in the human brain. Sci. Rep. 2018;8(1):1–9.
Simko M, Mattsson MO. Extremely low frequency electromagnetic fields as effectors of cellular responses in vitro: possible immune cell activation. J Cell Biochem. 2004;93(1):83–92. doi: 10.1002/jcb.20198.
Rosado MM, Simkó M, Mattsson MO, Pioli C. Immune-Modulating Perspectives for Low Frequency Electromagnetic Fields in Innate Immunity. Frontiers in public health. 2018;6:85. https://doi.org/10.3389/fpubh.2018.00085
Selmaoui B, Bogdan A, Auzeby A, Lambrozo J, Touitou Y. Acute exposure to 50 Hz magnetic field does not affect hematologic or immunologic functions in healthy young men: a circadian study. Bioelectromagnetics. 1996;17(5):364-372.
Selmaoui B, Lambrozo J, Sackett-Lundeen L, Haus E, Touitou Y. Acute exposure to 50-Hz magnetic fields increases interleukin-6 in young healthy men. J Clin Immunol. 2011; 31(6):1105–1111. doi:10.1007/s10875-011-9558-y
Gorgo YuP, Greckiy IO, Demydova OI. The use of luminos bacteria Photobacterium phosphoreum as a bioindicator of geomagnetic activity. Innov Biosyst Bioeng. 2018;2(4):271-277. doi:10.20535/ibb.2018.2.4.151459.
Uribe-Querol E, Rosales C. Control of Phagocytosis by Microbial Pathogens. Front Immunol. 2017;8:1368. doi:10.3389/fimmu.2017.01368.
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