The role of computed tomography in the diagnosis of lung cancer - a case report
DOI:
https://doi.org/10.12775/JEHS.2022.12.01.011Keywords
computed tomography, diagnosis of lung cancer, a case reportAbstract
Introduction Lung cancer has been the main oncological problem in the world for years. It is extremely important to use appropriate diagnostic methods that enable its detection and implementation of appropriate treatment. Aim The presented case shows the advantage of computed tomography over chest X-ray (X-ray) in visualizing neoplastic changes in the lungs. Case Study The paper presents a description of a patient diagnosed with centrally located advanced lung adenocarcinoma with a strong expression of PD-L1 qualified for treatment with pembrolizumab. Results and Discussion Presented case confirms that X-ray is less sensitive, especially in the case of centrally located tumors. Therefore, the emergence of a new cough in a smoker or ex-smoker should raise concerns related to lung cancer despite a normal X-ray image. The central location of the tumor may cause dramatic course of the symptoms. In the presented case, a sudden significant deterioration of the condition was observed due to atelectasis of the entire lung. Haemoptysis observed during hospitalization was another symptom of centraly located tumor mass. Conclusions In conclusion, the history of cigarette smoking, presence of typical symptoms should provide an in-depth diagnosis of lung cancer, despite normal X-ray. Diagnostic procedures include computed tomography in the first place. The course of centrally localized disease may change rapidly during on first cycle of treatment. Due to the possibility of serious complications of the ongoing neoplastic disease, the patient should be under constant medical supervision.References
Thakur SK, Singh DP, Choudhary J. Lung cancer identification: a review on detection and classification. Cancer Metastasis Rev. 2020;39(3):989-998. doi: 10.1007/s10555-020-09901-x.
Farsad M. FDG PET/CT in the Staging of Lung Cancer. Curr Radiopharm. 2020;13(3):195-203. doi: 10.2174/1874471013666191223153755.
Duma N, Santana-Davila R, Molina JR. Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment. Mayo Clin Proc. 2019;94(8):1623-1640. doi: 10.1016/j.mayocp.2019.01.013.
Goebel C, Louden CL, McKenna R Jr, Onugha O, Wachtel A, Long T. Diagnosis of Non-small Cell Lung Cancer for Early Stage Asymptomatic Patients. Cancer Genomics Proteomics. 2019;16(4):229-244. doi: 10.21873/cgp.20128.
Calvo Temprano D, Esteban E, Jiménez Fonseca P, Fernández-Mariño B. CT scan prior to radiotherapy in unresectable, locally advanced, non-small cell carcinoma of the lung: is it always necessary? Clin Transl Oncol. 2017;19(1):105-110. doi: 10.1007/s12094-016-1510-4.
Artal-Cortés A, Felices-Lobera P, Márquez-Medina D. Massive Hemoptysis after the First Administration of Pembrolizumab in a Strongly Positive, Centrally Located NSCLC. J Thorac Oncol. 2018;13(5):e76-e77. doi: 10.1016/j.jtho.2017.12.004.
Henschke CI, McCauley DI, Yankelevitz DF, et al. Early Lung Cancer Action Project: overall design and findings from baseline screening. Lancet. 1999;354(9173):99-105.
Sobue T, Moriyama N, Kaneko M, et al. Screening for lung cancer with low-dose helical computed tomography: anti-lung cancer association project. J Clin Oncol. 2002;20(4):911-920.
Panunzio A, Sartori P. Lung Cancer and Radiological Imaging. Curr Radiopharm. 2020;13(3):238-242. doi: 10.2174/1874471013666200523161849.
Sim AJ, Kaza E, Singer L, Rosenberg SA, A review of the role of MRI in diagnosis and treatment of early stage lung cancer, Clinical and Translational Radiation Oncology, 2020;24:16-22. doi: 10.1016/j.ctro.2020.06.002.
Mihoubi Bouvier F, Thomas De Montpréville V, Besse B, et al. Can MRI differentiate surrounding vertebral invasion from reactive inflammatory changes in superior sulcus tumor? Eur Radiol. 2021. doi: 10.1007/s00330-021-08001-w. Epub ahead of print.
Manenti G, Raguso M, D'Onofrio S, et al. Pancoast tumor: the role of magnetic resonance imaging. Case Rep Radiol. 2013;2013:479120. doi: 10.1155/2013/479120.
Kandathil A, Kay FU, Butt YM, Wachsmann JW, Subramaniam RM. Role of FDG PET/CT in the Eighth Edition of TNM Staging of Non-Small Cell Lung Cancer. Radiographics. 2018;38(7):2134-2149. doi: 10.1148/rg.2018180060.
Szyszko TA, Yip C, Szlosarek P, Goh V, Cook GJ. The role of new PET tracers for lung cancer. Lung Cancer. 2016;94:7-14. doi: 10.1016/j.lungcan.2016.01.010.
Nasim F, Sabath BF, Eapen GA. Lung Cancer. Med Clin North Am. 2019;103(3):463-473. doi: 10.1016/j.mcna.2018.12.006.
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