The severity of essential hypertension in terms of blood pressure values does not depend on NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphisms in the West-Ukrainian population
DOI:
https://doi.org/10.12775/JEHS.2021.11.10.032Keywords
NOS3 (rs2070744) and GNB3 (rs5443) genes, Arterial Hypertension, RiskAbstract
Objective: to evaluate the association of essential arterial hypertension (EAH) and its severity with genes polymorphism of NOS3 (rs2070744) and GNB3 (rs5443) in West-Ukrainian population.
Materials and methods. One-hundred EAH patients (48 – healthy control) participated in the cohort case-control study. Blood pressure (BP), Creatinine, glucose, lipids panel were studied. GNB3 (rs5443) and NOS3 (rs2070744) genotyping performed by TaqMan probes (CFX96™Real-Time PCR). Risk assessed by Relative Risk, Odds Ratio and 95% Confidential intervals.
Results. A mutation of the NOS3 gene (786T>C, rs2070744) and the GNB3 gene (825C>T, rs5443) in the homozygous state in the West-Ukrainian population suffers from EAH occurs with a frequency of 16.67% and 8.33%, with no differences with the control subjects (p>0.05). In both groups dominate the T-allele of the NOS3 gene and the C-allele of the GNB3 gene: in patients by 12.5% (c2=4.50; p=0.034) and 41.66% (c2=50.0; p<0.001), in the control – by 25.0% (c2=12.0; p<0.001) and 40.0% (c2=33.33; p<0.001), respectively. The results of the binary logistic regression analysis did not confirm the prediction of the EAH appearance by polymorphic variants of the NOS3 (rs2070744) and GNB3 (rs5443) genes. However, the TT genotype of the GNB3 gene (rs5443) increases unreliably the EAH risk almost twice as likely [OR=2.0; OR 95%CI:0.40-10.82; p>0.05]. Epidemiological analysis did not confirm the association of the NOS3 gene with the EAH severity. But T-allele of the GNB3 gene increases the probability of high normal BP almost 5 times [OR=4.86; OR 95%CI:0.99-24.75; p=0.042].
Conclusions: NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphisms are not associated with blood pressure values and EAH severity as well.
References
Tegegne BS, Man T, van Roon AM, Asefa NG, Riese H, Nolte I, Snieder H (2020): Heritability and the Genetic Correlation of Heart Rate Variability and Blood Pressure in >29 000 Families: The Lifelines Cohort Study. Hypertension 2020; 76(4): 1256-1262. https://doi.org/10.1161/HYPERTENSIONAHA.120.15227.
Bryan Williams, Giuseppe Mancia, Wilko Spiering, et. al, ESC Scientific Document Group. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). Eur Heart J 2018; 39(33):3021-3104. https://doi.org/10.1093/eurheartj/ehy339
Visseren FLJ, Mach F, Smulders YM, et al ESC National Cardiac Societies; ESC Scientific Document Group. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J 2021;42(34):3227-3337. https://doi.org/10.1093/eurheartj/ehab484.
Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S. Endothelium-dependent contractions and endothelial dysfunction in human hypertension. Br J Pharmacol. 2009;157(4):527-536. doi:10.1111/j.1476-5381.2009.00240.x
Liu, Q.; Cui, H.; Ma, Y.; Han, X.; Cao, Z.; Wu, Y. Triglyceride-glucose index associated with the risk of cardiovascular disease: the Kailuan study. Endocrine 2021; Sep 20. https://doi.org/10.1007/s12020-021-02862-3.
Semianiv MM, Sydorchuk LP, Dzhuryak VS, Gerush OV, Palamar AO, Muzyka NY, Korovenkova OM, Blazhiievska OM, Sydor VV, Sydorchuk AR, Semianiv IO, Sydorchuk RI. Association of AGTR1 (rs5186), VDR (rs2228570) genes polymorphism with blood pressure elevation in patients with essential hypertension in Ukrainian population. J Medicine and Life 2021;14(4): November – December, in press
Repchuk Y, Sydorchuk L, Fedoniuk L, Nebesna Z, Vasiuk V, Sydorchuk A, Iftoda O. Association of Lipids’ Metabolism with Vitamin D Receptor (rs10735810, rs222857) and Angiotensinogen (rs699) Genes Polymorphism in Essential Hypertensive Patients. Open Access Maced J Med Sci 2021;9(A):1052-6. https://oamjms.eu/index.php/mjms/article/view/6975
Repchuk Y, Sydorchuk LP, Sydorchuk AR, Fedonyuk LY, Kamyshnyi O, Korovenkova O, Plehutsa IM, Dzhuryak VS, Myshkovskii YM, Iftoda OM, Sydorchuk RI. Blood pressure, obesity and di-abetes mellitus linkage with an-giotensinogen gene (AGT 704T>C/rs699) polymorphism in hypertensive patients. Bratislava Medical Journal 2021; 122(10):715-720. https://doi.org/10.4149/BLL_2021_114.
Semianiv M, Sydorchuk L, Fedonyuk L, Nebesna Z, Kamyshnyi O, Sydorchuk A, Vasiuk V, Dzhuryak V, Semianiv I, Sydorchuk R. Metabolic and Hormonal Prognostic Markers of Essential Arterial Hypertension Considering the Genes Polymorphism AGTR1 (rs5186) and VDR (rs2228570). Romanian Journal of Diabetes Nutrition and Metabolic Diseases 2021;28 (3):284-91. https://www.rjdnmd.org/index.php/RJDNMD/article/view/1049.
Prysyazhnyuk V, Sydorchuk L, Sydorchuk R, Prysiazhniuk I, Bobkovych K, Buzdugan I, Dzuryak V, Prysyazhnyuk P. Glutathione-S-transferases genes-promising predictors of hepatic dysfunction. World J Hepatol 2021; 13(6):620-633. doi: 10.4254/wjh.v13.i6.620 https://www.wjgnet.com/1948-5182/journal/v13/i6/index.htm
Sydorchuk LP, Dzhuryak VS, Sydorchuk AR, Levytska SA, Knut RP, Sokolenko MO, Iftoda OM, Kushnir OV, Popovych AI, Sydorchuk RI. Association of lipids' metabolism disorders with aldosterone synthase CYP11B2 (-344C/T) gene polymorphism in hypertensive patients depending on glomerular filtration rate. PharmacologyOnLine. 2020;2:230-242 https://pharmacologyonline.silae.it/files/archives/2020/vol2/PhOL_2020_2_A023_Sydorchuk.pdf
Prysyazhnyuk V, Voloshyn O, Prysiazhniuk I, Ilashchuk T, Sydorchuk L, Prysyazhnyuk P. Glutathione S-transferase T1 and M1 null genotype distribution among non-alcoholic fatty liver disease patients and its association with cytokine and adipokine profiles. Clin Exp HEPATOL 2020;6(2):142-149. https://doi.org/10.5114/ceh.2020.95678
Sydorchuk L, Dzhuryak V, Sydorchuk A, Levytska S, Petrynych V, Knut R, Kshanovska A, Iftoda O, Tkachuk O, Kyfiak P, Popovich, Khomko O, Sydorchuk R. The cytochrome 11B2 aldosterone synthase gene rs1799998 single nucleotide polymorphism determines elevated aldosterone, higher blood pressure, and reduced glomerular filtration, especially in diabetic female patients. Endocrine Regulations 2020;54(3):217-226. https://doi.org/10.2478/enr-2020-0024
Dzhuryak V, Sydorchuk L, Sydorchuk A, Kamyshnyi O, Kshanovska A, Levytska S, Knut R, Sheremet M, Ivashchuk S, Petrynych O, Kazantseva T, Nikyfor L, Melnychuk L, Sokolenko A, Yarynych Yu, Semianiv M, Repchuk Yu, Voroniuk K, Sydorchuk R, Sokolenko L, Iftoda O, Kushnir O. The cytochrome 11B2 aldosterone synthase gene CYP11B2 (RS1799998) polymorphism associates with chronic kidney disease in hypertensive patients. Biointerface Research in Applied Chemistry 2020;10(3):5406-5411. https://doi.org/10.33263/BRIAC103.406411
Sydorchuk LP, Sokolenko AA, Sydorchuk AR, Kryklyvets LG, Biryuk IG, Fliundra IG, Sokolenko MA. Insulin resistance in patients with arterial hypertension and abdominal obesity depending on ACE and PPAR-γ2 genes polymorphism: A new opinion concerning an old problem. New Armenian Medical Journal 2015; 9:43-51.
Sydorchuk LP, Serdulets YI, Sydorchuk AR, et al. The polymorphism of matrilin-3 (rs77245812) and interleukin-10 (rs1800872) genes in osteoarthritis patients with arterial hypertension, obesity and type 2 diabetes mellitus. Arch Balk Med Union 2017; 52:422-429.
Sydorchuk LP, Gaborets IY, Sydorchuk AR, Ursuliak YuV, Sokolenko AA, Ivashchuk S, Biryuk IG, Kostenko VV. Combined Effects of ACE (I/D) and eNOS (894T>G) Genes Polymorphism in Patients with Arterial Hypertension in the Realization of Molecular Mechanisms of Left Ventricular Hypertrophy. New Armenian Medical J 2013; 7:32-42.
Sydorchuk L, Yarynych Y, Knut R, Sydorchuk A, et al. Hepatocytes' function and adipokines in patients with non-alcoholic fatty liver disease depending on the ACE (rs4646994) and PPAR-γ2 (rs1801282) genes' polymorphisms. Rev Med Chir Soc Med Nat Iaşi 2018; 122(2):358-364. https://www.revmedchir.ro/index.php/revmedchir/article/view/1170/1019
Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 2006; 113(15): 1888-904. https://doi.org/10.1161/CIRCULATIONAHA.105.563213.
Li HL, Zhang YJ, Chen XP, Luo JQ, Liu SY, Zhang ZL. Association between GNB3 c.825C > T polymorphism and the risk of overweight and obesity: A meta-analysis. Meta Gen 2016; 9:18-25. https://doi.org/10.1016/j.mgene.2016.03.002.
Fattakhov N, Smirnova L, Atochin D, Parshukova D, et al. Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and metabolic syndrome in healthy subjects and schizophrenia patients. Int J Obes (Lond) 2018; 42(12): 2036-2046. https://doi.org/10.1038/s41366-018-0124-z.
Gaunt TR, Smith GD. eNOS and coronary artery disease: Publication bias and the eclipse of hypothesis-driven meta-analysis in genetic association studies. Gene 2015; 556(2):257-258. https://doi.org/10.1016/j.gene.2014.11.052.
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