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Journal of Education, Health and Sport

Clinical and metabolic parameters, Ca2+, parathormone depending on serum 25(OH)D concentration in hypertensive patients in the West-Ukrainian population
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Clinical and metabolic parameters, Ca2+, parathormone depending on serum 25(OH)D concentration in hypertensive patients in the West-Ukrainian population

Authors

  • Marianna Semianiv Family Medicine Department, Bukovinian State Medical University, Chernivtsi https://orcid.org/0000-0003-4169-7142
  • Larysa Sydorchuk Family Medicine Department, Bukovinian State Medical University, Chernivtsi https://orcid.org/0000-0001-9279-9531

DOI:

https://doi.org/10.12775/JEHS.2021.11.12.010

Keywords

25(OH)D, essential arterial hypertension, сlinical parameters, metabolic parameters, Ca2, parathormone

Abstract

Introduction. Low plasma levels of 25-OH vitamin D (25(OH)D) have been associated with an increased prevalence of hypertension. The purpose of the research was to establish the association of clinical and metabolic parameters, Ca2+, parathormone and serum 25(OH)D concentration in hypertensive patients in the West-Ukrainian population. Material and method. 100 subjects with essential arterial hypertension (EAH) and target-organ damaging (2nd stage), moderate, high, very high cardiovascular risk were involved in the case-control study. Among them, 70,84% females, 29,16% males, mean age 57,86±7,81 yo. The control group consisted of 60 healthy individuals. All recruited patients were examined for heart rate, systolic and diastolic blood pressure (SBP, DBP); SCORE, BMI, waist and hip circumference (WC, HC); lipid panel, serum glucose and ionized calcium, 25(OH)D, parathormone levels were studied. Patients were divided into groups depending on total serum 25(OH)D concentration. Results. Low 25(OH)D concentration (<30 ng/ml) in patients with EAH was associated with arrhythmia, headache, sleep disturbance, weakness, fatigue, and increased total 10-year risk for fatal CVD SCORE>5,0%. We found higher SBP and DBP by 9,12% (р=0,014) and 5,17% (р=0,047), higher BMI in men and women – by 20-28,11% (р<0,05), as well as higher values of WC and HC by 8,69-11,92% (р<0,05) in hypertensive patients with hypovitaminosis D. In addition, obesity (BMI≥30,0 kg/m2), hyperglycemia, hypertriglyceridemia was more frequent – by 43% (p<0,05), 43,13% (p<0,001) and 59,37% (p=0,023), respectively. The level of ionized Ca2+ was slightly higher in healthy individuals (p=0,047) with low vitamin D concentration. PTH was compensatory increased by 31,85% (p=0,048) in hypertensive patients with hypovitaminosis D.

Conclussions. Hypovitaminosis D is associated with more severe metabolic, hemodynamic disorders and clinical symptoms in hypertensive patients in the West-Ukrainian population.

References

References

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Published

2021-12-14

How to Cite

1.
SEMIANIV, Marianna and SYDORCHUK, Larysa. Clinical and metabolic parameters, Ca2+, parathormone depending on serum 25(OH)D concentration in hypertensive patients in the West-Ukrainian population. Journal of Education, Health and Sport. Online. 14 December 2021. Vol. 11, no. 12, pp. 150-157. [Accessed 4 July 2025]. DOI 10.12775/JEHS.2021.11.12.010.
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Vol. 11 No. 12 (2021)

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Copyright (c) 2021 Marianna Semianiv, Larysa Sydorchuk

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