Therapeutic and preventive effect of feed additives on the state of periodonts of rats with experimental dysbiosis
Keywordsdysbiosis, periodontium, feed additives, high-oleic sunflower cake, periodontal protection
Aim. Determine the therapeutic and prophylactic effect of feed additives on the condition of the periodontium in case of dysbiosis.
Methods. As feed additives, we used flour from pea straw (FPS), oilcake from ordinary (high-linoleic) sunflower seeds (OOS) and oilcake from high-oleic sunflower seeds (OHOS), which were added to the composition of feed for rats in an amount of 10% instead of the same amount of grain wheat. The duration of feeding was 18 days. Experimental dysbiosis was reproduced using the antibiotic lincomycin. The activity of urease, lysozyme, catalase, elastase and the content of malondialdehyde (MDA) were determined in the gums of rats.
Results. An increase in the level of urease, elastase, MDA and a slight decrease in the activity of lysozyme and catalase were found in rats with dysbiosis. The consumption of FPS and OOS had little effect on the biochemical parameters of the gums; however, the consumption of OHOS significantly reduced the activity of elastase, the level of MDA and normalized the level of urease.
Conclusion. Under conditions of dysbiosis, periodontitis develops, which can be prevented by consuming high-oleic sunflower oilcake.
Levitsky AP. Disbiotic syndrome: etiology, pathogenesis, clinic, prevention and treatment. Dentistry Bulletin. 2019;10:14-20. (in Russian)
Levitsky AP, Lisnichuk MV, Zubachik VM. The substantiation of pathogenic role of dysbiotic conditions of oral cavity at gingivitis occurence at the experiment. Experimental and clinical phyzyology and biochemistry. 2008; 2 (42):28-31. (in Ukrainian)
Levitsky AP, Lapinska AP, Sichkar VI [and others]. Prospects for the use of pea straw in the production of mixed feed products. Cereals and compound feed. 2018;18(1-2):39-44. (in Ukrainian)
Levitsky AP, Selivanskaya IA, Sichkar VI [and others]. Antidysbiosis effect of soy straw flour. Cereals and compound feed. 2013; 2(50): 16-18. (in Russian)
Levitsky AP, Makarenko OA, Demyanenko SA. Methods of experimental dentistry (teaching aid). Simferopol, Tarpan, 2018:78. (in Russian)
Ermakov AI. Biochemical research methods of plants. Leningrad, 1987:430. (in Russian)
Levitsky AP, Makarenko OA, Khodakov IV. Methods to investigate fats and oils. Odessa. 2015:32. (in Russian)
Truhacheva NV. Mathematical Statistics in biomedical research using application package Statistica. Moskow, GJeOTAR-Media, 2012:379. (in Russian)
How to Cite
Copyright (c) 2021 A. Levitsky, A. Markov, T. Pupin, I. Selivanskaya, A. Lapinskaya
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Number of views and downloads: 143
Number of citations: 0