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Journal of Education, Health and Sport

Liver dysfunction in children with community-acquired pneumonia: the role of infectious and inflammatory markers
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  • Liver dysfunction in children with community-acquired pneumonia: the role of infectious and inflammatory markers
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Liver dysfunction in children with community-acquired pneumonia: the role of infectious and inflammatory markers

Authors

  • Veronika Dudnyk National Pirogov Memorial Medical University
  • Valentyna Pasik National Pirogov Memorial Medical University

DOI:

https://doi.org/10.12775/JEHS.2021.11.11.015

Keywords

cytokines, C-reactive protein, fibrinogen, alanine aminotransferase, aspartate aminotransferase, liver, community-acquired pneumonia in children, early age

Abstract

Markers of infectious-inflammatory process were studied by determining the levels of pro-inflammatory cytokines - interleukin (IL) 1 and IL-6 and proteins of the acute phase of inflammation - C-reactive protein (CRP) and fibrinogen in the serum of children with community-acquired pneumonia. 

It was found that the course of community-acquired pneumonia is accompanied by an increase in serum concentrations of IL-1 and IL-6 in children in parallel with the disease severity. The synthesis of pro-inflammatory cytokines stimulates the production of acute CRP, but reduces the concentration of fibrinogen in the serum of sick children. The revealed connections between the content of the studied cytokines at the systemic level and multidirectional changes in the indicators of the acute phase of inflammation indicate a violation of the liver, where proteins are synthesized in the study.

It is shown that with increasing severity of pneumonia, the enzyme activity of aminotransferases - alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the serum of children increases with a simultaneous decrease in the de Ritis coefficient, indicating "hepatic" genesis. High levels of aminotransferase is closely correlated with the activity of the infectious-inflammatory process, as indicated by the positive correlation between the level of IL-1 and ALT (r = 0.047) and AST (r = 0.111). At the same time, there is a negative correlation between the levels of IL-1, CRP and the activity of aminotransferases in blood serum.

References

Leung AKC, Wong AHC, Hon KL. Community-acquired pneumonia in children. Recent Pat Inflamm Allergy Drug Discov. 2018;12(2):136-144.

Dean P, Florin TA. Factors associated with pneumonia severity in children: a systematic review. J Pediatric Infect Dis Soc. 2018;7(4):323-334.

Mizgerd JP. Pathogenesis of severe pneumonia: advances and knowledge gaps. Curr Opin Pulm Med. 2017;23(3):193-197.

Lyons PG, Kollef MH. Prevention of hospital-acquired pneumonia. Curr Opin Crit Care. 2018;24(5):370-378.

Shiba D., Hifumi T., Watanabe Y., Shimizu M., Isokawa S., Toya N., Iwasaki T., Otani N., Ishimatsu S. Association between inflammation in acute phase and early onset pneumonia in patients with out-of-hospital cardiac arrest treated with extracorporeal cardiopulmonary resuscitation. Acute Med Surg. 2020;7(1):e610.

McMaster WG, Kirabo A, Madhur MS, Harrison DG. Inflammation, immunity, and hypertensive end-organ damage. Circ Res. 2015;116(6):1022-33.

Schuijt TJ, Lankelma JM, Scicluna BP, de Sousa e Melo F, Roelofs JJ, de Boer JD, Hoogendijk AJ, de Beer R, de Vos A, Belzer C, de Vos WM, van der Poll T, Wiersinga WJ. The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia. Gut. 2016;65(4):575-83.

Robinson MW, Harmon C, O'Farrelly C. Liver immunology and its role in inflammation and homeostasis. Cell Mol Immunol. 2016;13(3):267-76

Satici C, Demirkol MA, Sargin Altunok E, Gursoy B, Alkan M, Kamat S, Demirok B, Surmeli CD, Calik M, Cavus Z, Esatoglu SN. Performance of pneumonia severity index and CURB-65 in predicting 30-day mortality in patients with COVID-19. Int J Infect Dis. 2020;98:84-89.

Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957;28(1):56-63.

Rudd J.M., Pulavendran S., Ashar H.K., Ritchey J.W., Snider T.A., Malayer J.R., Marie M., Chow V.T.K., Narasaraju T. Neutrophils induce a novel chemokine receptors repertoire during influenza pneumonia. Front Cell Infect Microbiol. 2019;9:108.

Ridker P.M., Lüscher T.F. Anti-inflammatory therapies for cardiovascular disease. Eur Heart J. 2014;35(27):1782-91.

Dinarello C.A. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol Rev. 2018;281(1):8-27.

Dinarello C.A. The IL-1 family of cytokines and receptors in rheumatic diseases. Nat Rev Rheumatol. 2019;15(10):612-632.

Tanaka T., Narazaki M., Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014;6(10):a016295.

Polepalle T., Moogala S., Boggarapu S., Pesala D.S., Palagi F.B. Acute phase proteins and their role in periodontitis: a review. J Clin Diagn Res. 2015;9(11):ZE01-5.

Rajab I.M., Hart P.C., Potempa L.A. How C-reactive protein structural isoforms with distinctive bioactivities affect disease progression. Front Immunol. 2020;11:2126.

Ewid M., Sherif H., Allihimy A.S., Alharbi S.A., Aldrewesh D.A., Alkuraydis S.A., Abazid R. AST/ALT ratio predicts the functional severity of chronic heart failure with reduced left ventricular ejection fraction. BMC Res Notes. 2020;13(1):178.

Cai SY, Boyer JL. The role of inflammation in the mechanisms of bile acid-induced liver damage. Dig Dis. 2017;35(3):232-234.

Wang H, Luo H, Wan X, Fu X, Mao Q, Xiang X, Zhou Y, He W, Zhang J, Guo Y, Tan W, Deng G. TNF-alpha/IFN-gamma profile of HBV-specific CD4 T cells is associated with liver damage and viral clearance in chronic HBV infection. J Hepatol. 2020;72(1):45-56.

Olteanu S, Kandel-Kfir M, Shaish A, Almog T, Shemesh S, Barshack I, Apte RN, Harats D, Kamari Y. Lack of interleukin-1alpha in Kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice. Dig Liver Dis. 2014;46(5):433-9.

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Published

2021-11-29

How to Cite

1.
DUDNYK, Veronika & PASIK, Valentyna. Liver dysfunction in children with community-acquired pneumonia: the role of infectious and inflammatory markers. Journal of Education, Health and Sport [online]. 29 November 2021, T. 11, nr 11, s. 169–181. [accessed 27.3.2023]. DOI 10.12775/JEHS.2021.11.11.015.
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Vol. 11 No. 11 (2021)

Section

Research Articles

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Copyright (c) 2021 Veronika Dudnyk, Valentyna Pasik

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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