Морфологічні особливості виразки дванадцятипалої кишки у дітей в залежності від тяжкості захворювання та наявності Н. Pylori інфекції = Morphological features of duodenal ulcer in children, depending on the severity of the disease and the presence of H. Pylori infection

Abstract

Dudnyk V. M., Buglova N. O. Морфологічні особливості виразки дванадцятипалої кишки у дітей в залежності від тяжкості захворювання та наявності Н. Pylori інфекції = Morphological features of duodenal ulcer in children, depending on the severity of the disease and the presence of H. Pylori infection. Journal of Education, Health and Sport. 2016;6(6):253-262. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.55360

http://ojs.ukw.edu.pl/index.php/johs/article/view/3574

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© The Author (s) 2016;

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 05.05.2016. Revised 25.05.2016. Accepted: 10.06.2016.

МОРФОЛОГІЧНІ ОСОБЛИВОСТІ ВИРАЗКИ ДВАНАДЦЯТИПАЛОЇ КИШКИ У ДІТЕЙ В ЗАЛЕЖНОСТІ ВІД ТЯЖКОСТІ ЗАХВОРЮВАННЯ ТА

НАЯВНОСТІ Н. PYLORI ІНФЕКЦІЇ

Morphological features of duodenal ulcer in children, depending on the severity of the disease and the presence of H. pylori infection

В. М. Дудник, Н. О. Буглова

V. M. Dudnyk, N. O. Buglova

Вінницький національний медичний університет ім. М.І.Пирогова, м. Вінниця

кафедри педіатрії №2

Vinnitsya National Pirogov Memorial Medical University, Ukraine

Department of Pediatrics No 2

Abstract

The article presents data on the morphological features of the duodenal mucosa, depending on the varying degrees of severity, and the presence of H. pylori infection in children with duodenal ulcer. Duodenal ulcer is one of the most serious diseases of gastroduodenal zone accompanied by destructive duodenal mucosa membrane changes. It is known that the morphological study of the duodenum is an important method for determining the severity of the inflammatory process and  especially important as the criterion of the patient's recovery.

The  analysis of morphometric studies  found that in children with duodenal ulcer associated with H.pylori was detected a significant increase (p <0.05) in the number of destroyed and exfoliated epithelial cells, segmented neutrophils and lymphocytes in the duodenal mucosa compared with  H.pylori (-) patients and the control group respectively. Also showed a significant  increase in the relative amount of the affected epithelial cells in children with severe H.pylori (+) duodenal ulcer (to 33.85%) with respect to children with moderate gravity (p <0.05). It was founded that in children with severe H.pylori (+) duodenal ulcer was significant (p <0.05) increase in the total number of inflammatory cells almost 2-fold compared to patients with duodenal ulcer of medium severity, which indicates a clear dependence of inflammatory activity in  the duodenal mucosa to the presence of H.pylori infection and severity of the disease.

Keywords: children, duodenal ulcer, H.рylori, duodenal mucosa.