Condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs under the condition of immobilization stress
DOI:
https://doi.org/10.12775/JEHS.2021.11.05.033Keywords
immobilization stress, peroxide lipid oxidation, antioxidant systemAbstract
We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’ lungs under the conditions of immobilization stress. The experiment was conducted on 40 female guinea pigs weighing 0.18-0.20 kg. The animals were divided into 4 groups, each contained 10 guinea pigs: I – intact guinea pigs (control), II–guinea pigs with model of IS on1st day of experiment;Ш–animals on 2nd day of experiment;IV- group of animals on 34th day of experimental model of IS.
The results of our experimental work showed a significant accumulation of lipid peroxidation products in the lung`s tissure in different periods (on 1st, 2nd and 34th days) of immobilization stress. The state of antioxidant defence was characterized by moderate decrease of inzymes activity (superoxide dismutase, catalase and ceruloplasmin). disorders of balance between pro-oxidant and antioxidant systems couse oxidative stress development.
References
Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists. J. Abraham, J. O. Mudd, N. K. Kapur [et al.] J. Am. Coll. Cardiol. 2009; 53(15): 1320–1325.
Post-traumatic stress. The mechanisms of trauma. D. Guerreiro, B. Brito, J. L. Bartista et al Acta Med. Port. 2007; 20(4): 347–354.
L. Lu, M. T. Quinn, Y. Sun Oxidative stress in the infarcted heart : role of de novo angiotensin II production. Biochemical and Biophysical Research Communications. 2004; 325(3): 943–951.
Khasky A.D., Smith J.C. Stress, relaxation states, and creativity. Percept. Mot. Skills. 2000,88 (22), 409416.
Karanth J., Jeevaratnam K. Oxidative stress and antioxidant status in rat blood, muscle: effect of dietary lipid, carnitine and exercise bit. J. Vitam. Nutr. Res. 2005;75(5):333-339.
Gorizontov PD, Belousova OI, Fedotov MI. Stress i sistema krovi. M.: Meditsina. 1983: 338 s.[Rusian]
Gavrilov A.B., Myshkorudnaya M.I. Spektrofotometricheskoye opredeleniye soderzhaniya gidroperekisey lipidov v plazme. Laboratornaya diagnostika ishemicheskoy bolezni serdtsa, - K.: Zdorov'ya, 1989,170-171. [Rusian]
Korobeynikov E.N. Modifikatsiya opredeleniya produktov POL v reaktsii s tiobarbiturovoy kislotoy Lab. delo 1989,7,8-10. [Rusian]
Fried, R. (1975). Enzymatic and non-enzymatic assay of super oxide dismutase. Biochemie, (57), 65, 657-660.
Holmes, R. & Masters, C. (1970). Epigenetic interconversions of the multiple forms of mouse liver catalase. FEBS Lett.,(11), 1, 45-48.
Kolb VG, Kamyshnikov VS. Opredeleniye aktivnosti tseruloplazmina v krovi. Spravochnik po klinicheskoy khimii. Minsk: Belarus'. 1982: 290–291. [Rusian]
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