Immunohistochemical features of the fallopian tubes’ structure in case of fetuses with a gestational term of 21-28 weeks from mothers with a chronic infection of the lower genital tracts
DOI:
https://doi.org/10.12775/JEHS.2021.11.08.050Keywords
fetus, pregnancy, fallopian tubes, chronic infection, endotheline-1, collagenAbstract
In the following article we are disclosing immunohistochemical features of the fallopian tubes’ structure in case of fetuses with a gestational term of 21-28 weeks. We have studied the structure of organs of 15 fetuses from mothers with a chronic infection of the lower genital tracts (HILGT) (the group of comparison) relatively to one in case of 15 fetuses from mothers with a physiological pregnancy (the main group). All fetuses had a gestational term of 21-28 weeks and had died intranatally as a result of an acute disorder of uterine-placental circulation. Methods of reearch: organometric, histological, immunohistochemical and statistical. The complex research allowed to reveal a probable decrease of the organometric data as well as indicators of thickness of the main structural components of the organs’ wall in case of fetuses from mothers of the group of comparison relatively to ones in case of fetuses from the main group. By applying histological method we had reveled a disorder in the strucuture of mucous and muscular membranes in the structure of organs of fetuses from mothers with a pathology of pregnancy, which is manifested by decreasing of number of folds, uneven thickness of the mucous membrane as well as disorder in formation of the muscular membrane’ layers. Immunohistochemical method has revealed an increase of apoptotically changed mucosal cells in the fallopian tubes of fetuses from mothers with HILGT. By applying MCAT to endotheline-1 we have revealed an increased glow of endithelial cells in vessels both of arterial and venous types in the strucuture of the organs’ wall in case of fetuses from the group of comparison. During the study on the endocrine activity of organs of fetuses from mothers with complicated pregnancy we have postulated a probable decrease of the cells’ glow’ intensity towards MCAT of progesterone. At the same time, there is also an inflammatory infiltration in the mucous membrane of the fallopian tubes’ wall. The aforementioned changes in the strucuture as well as in the functional activity of fetuses’ organs from mothers’ with HILGT are formed under the influence of chronic hypoxia and endocrine insufficiency of the feto-placental complex, which is taking place in case of this pathology. Histological and immunohistochemical features of the fallopian tubes’ structure in case of fetuses from mothers with complicated pregnancy are indicating a disorder in formation and maturing of the organ as well as they could lead to development of ectopic pregnancy and tubal infertility in the subsequent ontogenesis.
References
Adams W. К. М. Influence of infection during pregnancy on fetal development / W. K. M. Adams, R. M. McAdams // Reproduction. – 2013. – № 1. – Р. 151-62.
Baker D. A. Issues and management of herpes in pregnancy / D. A. Baker // Int. J. Fertil. Women Med. – 2012. – Vol. 47, № 3. – Р. 129-139.
Cao B. Placental microbiome and its role in preterm birth / В. Cao, M. J. Stout [et al.] // Neoreviews. – 2014. – № 1. – Р. 537-545.
Charlier C. Infection and pregnancy: a threat for mother and child / С. Charlier, М. Lecuit // Presse. Med. – 2014. – № 43. – Р. 662-4.
Chin T. L. Viral infections in pregnancy: advice for healthcare workers / T. L. Chin, А. Р. MacGowan [et al.] // Hosp. Infect. – 2014. – № 87. – Р. 11-24.
Conde-Ferráez L. Human papillomavirus and Chlamydia trachomatis infection in gyneco-obstetric outpatients from a mexican hospital / L. Conde-Ferráez, J. R. Martíez [et al.] // Med. Microbiol. – 2017. – № 35. – Р. 74-79.
Conti N. Term histologic chorioamnionitis: a heterogeneous condition / N. Conti, М. Torricelli [et al.] // Eur. J. Obstet. Gynecol. Reprod. Biol. – 2015. – № 188. – Р. 34-8.
Barg Е. Ocena stanu zdrowia dzieci urodzonych z niską masą ciała: analiza wybranych parametrów metabolicznych i genetycznych / E. Barg. – Wrocław: Uniwersytet Medyczny im. Piastów Śląskich, 2013. – 245 s.
Ericson J. E. Chorioamnionitis: implications for the neonate / J. E. Ericson, М. М. Laughon // Сlin. Perinatol. – 2015. – № 42. – Р. 155-65.
Fox N. S. Combined fetal fibronectin and cervical length and spontaneous preterm birth in asymptomatic triplet pregnancies / N. S. Fox, А. Rebarber [et al.] // Matern. Fetal. Neonatal. Med. – 2012. – № 25 (11). – Р. 2308-11.
Glehn M. P. Prevalence of Trichomonas vaginalis in women of reproductive age at a family health clinic / М. Р. Glehn, L. C. Sá [et al.] // Infect. Dev. Ctries. – 2017. – № 31. – Р. 269-276.
Granot I. Endometrial inflammation and effect on implantation improvement and pregnancy outcome / I. Granot, Y. Gnainsky, N. Dekel // Reproduction. – 2012. – № 144 (6). – Р. 661-8.
Griffiths P. Cytomegalovirus / Р. Griffiths, S. Lumley // Curr. Opin. Infect. Dis. – 2014. – № 27. – Р. 554-9.
Atukorale P. U. Vascular targeting of nanoparticles for molecular imaging of diseased endothelium / P. U. Atukorale, G. Covarrubias [et al.] // Adv. Drug. Deliv. Rev. – 2017. – № 113. – Р. 141-156.
Halawa S. TORCH screening in pregnancy. Where are we now? An audit of use in a tertiary level centre / S. Halawa, L. McDermott [et al.] // Obstet. Gynaecol. – 2014. – № 34. – Р. 309-12.
Hornung S. Role of Chlamydia trachomatis and emerging Chlamydia-related bacteria in ectopic pregnancy in Vietnam / S. Hornung,В. С. Thuong [et al.] // Epidemiol. Infect. – 2015. – № 143. – Р. 2635-8.
Hui L. Perinatal outcome after maternal primary cytomegalovirus infection in the first trimester: a practical update and counseling aid / L. Hui, G. Wood // Prenat. Diagn. – 2015. – № 35. – Р. 1-7.
Karacan M. Screening cytomegalovirus, rubella and toxoplasma infections in pregnant women with unknown pre-pregnancy serological status / М. Karacan [et al.] // Arch. Gynecol. Obstet. – 2014. – № 290. – Р. 1115-20.
Kwit K. Pregnancy outcome and clinical status of gilts following experimental infection by H1N2, H3N2 and H1N1pdm09 influenza A viruses during the last month of gestation / К. Kwit, М. Pomorska-Mól, І. Markowska-Daniel // Arch. Virol. – 2015. – № 160. – Р. 2415-25.
Li J. J. Parvovirus infection: an immunohistochemical study using fetal and placental tissue / J. J. Li, Т. Henwood [et al.] // Pediatr. Dev. Pathol. – 2015. – № 18. – Р. 30-9.
Mienaltowski M. J. Structure, physiology, and biochemistry of collagens / M. J. Mienaltowski, D. E. Birk // Adv. Exp. Med. Biol. – 2014. – № 802. – Р. 5-29.
Moodley D. Pregnancy Outcomes in Association with STDs including genital HSV-2 shedding in a South African Cohort Study / D. Moodley, В. Sartorius [et al.] // Sex. Transm. Infect. – 2017. – № 10. – Р. 2017-053113.
Moreno-Diaz J. A. Herpes gestationis / J. A. Moreno-Diaz, V. Paredes-Solis [et al.] // Ginecol. Obstet. Mex. – 2014. – № 82. – Р. 697-704.
Ornoy A. Parvovirus B19 infection during pregnancy and risks to the fetus / А. Ornoy, Z. Ergaz // Birth. Defects. Res. – 2017. – № 15. – Р. 311-323.
Di Renzo G. C. Progesterone in normal and pathological pregnancy / G. C. Di Renzo, I. Giardina [et al.] // Horm. Mol. Biol. Clin. Investig. – 2016. – № 1. – Р. 35-48.
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