Use of white light therapy in treatment of non-motor symptoms in Parkinson’s disease
DOI:
https://doi.org/10.12775/JEHS.2021.11.09.036Keywords
Parkinson’s disease, non-motor symptoms, white light therapyAbstract
Introduction. Parkinson’s disease (PD) is a progressive neurodegenerative disorder, associated with selective loss of neurons in the substantia nigra. Parkinson’s disease revealed by motor and non-motor symptoms. Alternative therapies for cure non-motor symptoms are searched. One of them can be white light therapy, which is based on taking samples of light specified illuminance, time of day, period and head-to-light distance.
Brief description of the state of knowledge. The purpose of white light therapy is stabilization of the circadian melatonin secretion and improvement of circadian rhythmicity. Morning white light exposure allows to accelerate the circadian rhythm and is effective in cure of depression disorders. In turn evening light exposure is used to delayed the circadian rhythm and treat early awaking insomnia. The effectiveness of treatment by white light therapy other neurological and neuropsychiatric disease as depression or sleep disorder is well-documented.
Conclusions. White Light Therapy is a safe, easy to use, and inexpensive non-pharmacological treatment option with rare side effects. Research shows that light has a significant therapeutic effect on a broad spectrum of symptoms, such as tremor, bradykinesia, rigidity, insomnia. However more evidence is needed to define specific dose of light for treatment non-motor symptoms Parkinson’s disease and the regime of its intake (length of irradiation, time of day, distance between the head and the light source).
References
Stephen K. Van Den Eeden, Caroline M. Tanner, Allan L Bernstein, Robin D Fross, Amethyst Leimpeter, Daniel A. Bloch, Lorene M. Nelson Incidence of Parkinson’s Disease: Variation by Age, Gender, and Race/Ethnicity Am J Epidemiol 2003 Jun 1;157(11):1015-22. PMID: 12777365 DOI: 10.1093/aje/kwg068
A H Rajput Frequency and cause of Parkinson's disease Can J Neurol Sci 1992 Feb;19(1 Suppl):103-7. PMID: 1571854
Lorraine V Kalia, Anthony E Lang Parkinson's disease Lancet 2015 Aug 29;386(9996):896-912. Epub 2015 Apr 19. PMID: 25904081 DOI: 10.1016/S0140-6736(14)61393-3
Janice M Beitz Parkinson's disease: a review Front Biosci (Schol Ed) 2014 Jan 1;6:65-74. PMID: 24389262 DOI: 10.2741/s415
Ali Samii, John G Nutt, Bruce R Ransom Parkinson's disease Lancet 2004 May 29;363(9423):1783-93. PMID: 15172778 DOI: 10.1016/S0140-6736(04)16305-8
A Berardelli, G K Wenning, A Antonini, D Berg, B R Bloem, V Bonifati, D Brooks, D J Burn, C Colosimo, A Fanciulli, J Ferreira, T Gasser, F Grandas, P Kanovsky, V Kostic, J Kulisevsky, W Oertel, W Poewe, J-P Reese, M Relja, E Ruzicka, A Schrag, K Seppi, P Taba, M Vidailhet EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson's disease Eur J Neurol 2013 Jan;20(1):16-34. PMID: 23279440 DOI: 10.1111/ene.12022
Anthony H V Schapira, K Ray Chaudhuri, Peter Jenner Non-motor features of Parkinson disease Nat Rev Neurosci 2017 Jul;18(7):435-450. PMID: 28592904 DOI: 10.1038/nrn.2017.62
Sebastian Paus, Tanja Schmitz-Hübsch, Ullrich Wüllner, Antje Vogel, Thomas Klockgether, Michael Abele Bright light therapy in Parkinson's disease: a pilot study Mov Disord 2007 Jul 30;22(10):1495-1498. PMID: 17516492 DOI: 10.1002/mds.21542
Anna Wirz-Justice Francesco Benedetti Michael Terman Chronotherapeutics for Affective Disorders A Clinician’s Manual for Light and Wake Therapy Basel: Karger, Jen 2009 DOI: 10.1159/isbn.978-3-8055-9121-8
Sonja Rutten, Chris Vriend, Jan H Smit, Henk W Berendse, Adriaan W Hoogendoorn, Odile A van den Heuvel, Ysbrand D van der Werf A double-blind randomized controlled trial to assess the effect of bright light therapy on depression in patients with Parkinson's disease BMC Psychiatry 2016 Oct 21;16(1):355. PMID: 27769202 PMCID: PMC5073442 DOI: 10.1186/s12888-016-1050-z
M Terman, J S Terman Bright light therapy: side effects and benefits across the symptom spectrum J Clin Psychiatry 1999 Nov;60(11):799-808; quiz 809. PMID: 10584776
N Praschak-Rieder, A Neumeister, B Hesselmann, M Willeit, C Barnas, S Kasper Suicidal tendencies as a complication of light therapy for seasonal affective disorder: a report of three cases J Clin Psychiatry 1997 Sep;58(9):389-92. PMID: 9378689 DOI: 10.4088/jcp.v58n0903
J Haffmans, S Lucius, N Ham Suicide after bright light treatment in seasonal affective disorder: a case report J Clin Psychiatry 1998 Sep;59(9):478. PMID: 9771819 DOI: 10.4088/jcp.v59n0907a
Edda Pjrek, Dietmar Winkler, Matthäus Willeit, Anastasios Konstantinidis, Nikolaus Thierry, Siegfried Kasper Menstrual disturbances a rare side-effect of bright-light therapy Int J Neuropsychopharmacol 2004 Jun;7(2):239-40. Epub 2003 Feb 13. PMID: 14962352 DOI: 10.1017/S1461145703003997
P Dureau, J C Jeanny, B Clerc, J L Dufier, Y Courtois Long term light-induced retinal degeneration in the miniature pig Mol Vis 1996 Jun 21;2:7. PMID: 9238084
P F Gallin, M Terman, C E Remé, B Rafferty, J S Terman, R M Burde Ophthalmologic examination of patients with seasonal affective disorder, before and after bright light therapy Am J Ophthalmol 1995 Feb;119(2):202-10. PMID: 7832227 DOI: 10.1016/s0002-9394(14)73874-7
Karim Fifel , Aleksandar Videnovic Light Therapy in Parkinson's Disease: Towards Mechanism-Based Protocols Trends Neurosci 2018 May;41(5):252-254. PMID: 29588060 PMCID: PMC5924622 DOI: 10.1016/j.tins.2018.03.002
Gerald Pail, Wolfgang Huf, Edda Pjrek, Dietmar Winkler, Matthaeus Willeit, Nicole Praschak-Rieder, Siegfried Kasper Bright-light therapy in the treatment of mood disorders Neuropsychobiology 2011;64(3):152-62. PMID: 21811085 DOI: 10.1159/000328950
Sonja Rutten, Chris Vriend, Jan H. Smit, Henk W. Berendse, Eus J W van Someren, Adriaan W Hoogendoorn, W R Twisk, Ysbrand D. van der Werf, Odile A. van den Heuvel Bright light therapy for depression in Parkinson disease Neurology 2019 Mar 12;92(11):e1145-e1156 PMID: 30770426 DOI: 10.1212/WNL.0000000000007090
Gregory L Willis, E John D Turner Primary and secondary features of Parkinson's disease improve with strategic exposure to bright light: a case series study Chronobiol Int 2007;24(3):521-37. PMID: 17612949 DOI: 10.1080/07420520701420717
Aleksandar Videnovic, Elizabeth B Klerman, Wei Wang, Angelica Marconi, Teresa Kuhta, Phyllis C Zee Timed Light Therapy for Sleep and Daytime Sleepiness Associated With Parkinson Disease: A Randomized Clinical Trial JAMA Neurol 2017 Apr 1;74(4):411-418. PMID: 28241159 PMCID: PMC5470356 DOI: 10.1001/jamaneurol.2016.5192
Gregory L Willis, Cleo Moore, Stuart M Armstrong A historical justification for and retrospective analysis of the systematic application of light therapy in Parkinson's disease Rev Neurosci 2012 Mar 1;23(2):199-226. PMID: 22499678 DOI: 10.1515/revneuro-2011-0072
Rutten S, Vriend C, van den Heuvel OA, Smit JH, Berendse HW, van der Werf YD. Bright light therapy in Parkinson’s disease: an overview of the background and evidence. Parkinsons Dis. 2012;2012:767105. PMID: 23320250 PMCID: PMC3540893 DOI: 10.1155/2012/767105
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 © The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 566
Number of citations: 0