Is the determination of bone turnover markers and vitamin D useful in the diagnosis of degeneration spine disease?
DOI:
https://doi.org/10.12775/JEHS.2021.11.09.032Keywords
degenerative spine disease, back pain, markers of bone turnover, markers of cartilage damage, vitamin DAbstract
Abstract: Degenerative disease of the lumbar spine is one of the most common diseases of the human musculoskeletal system and a significant public health problem. The main manifestation of degenerative spine disease is back pain, which in most cases is treated symptomatically rather than causally. The diagnosis of degenerative spine disease has been previously based on medical history and diagnostic imaging. Recently, much attention has been devoted to the biochemical indicators of bone and cartilage metabolism, which are well understood among patients with osteoporosis. Bone turnover markers indicate the metabolic activity of bone and cartilage. They occur in blood serum, urine, and synovial fluid in the form of collagen-derived proteins or enzymes, involved in the formation or resorption of bone and cartilage tissue. The study below was aimed at assessing the usefulness of determining the markers of bone turnover and cartilage damage in the blood serum of people with degenerative disease of the lumbar spine diagnosed by MRI. The biochemical diagnostics included the measurement of inflammatory parameters. The results show that the degenerative disease of the spine is local, accompanied by inflammation, and vitamin D deficiency is among the factors leading to its development.
References
Wasiak R.; Kim J.Y.; Pransky G. Work disability and costs caused by recurrence of low back pain: longer and more costly than in first episodes: Spine 2006, 31(2): 219-225.
Sarah E.E. Mills; Karen P. Nicolson; Blair H. Smith. Chronic pain: a review of its epidemiology and associated factors in population-based studies.Br J Anaesth 2019, 123(2): 273-283.
Wong A.Y.; Karppinen J.; Samartzis D. Low back pain in older adults: risk factors, management options and future directions. Scoliosis Spinal Disord. 2017, 12: 14.
Jing Yu; Peter C.; Sally Roberts; Jill P.G. Urban. Elastic fiber organization in the intervertebral discs of the bovine tail. J Anat. 2002, 201(6): 465-475.
Choi Y.S. Pathophysiology of degenerative disc disease. Asian Spine J. 2009, 3(1): 39-44.
Mundy G.R. Metastasis to the bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer. 2002, 2(8): 584-593.
Bilsky M.H. New therapeutics in spine metastases. Expert Rev Neurother. 2005, 5(6): 831-840.
Roughley P.J. Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix. Spine 2004, 29(23): 2691-2699.
Chris Daly; Peter Ghosh; Graham Jenkin; David Oehme; Tony Goldschlager. A Review of Animal Models of Intervertebral Disc Degeneration: Pathophysiology, Regeneration, and Translation to the Clinic. Biomed Res Int. 2016, 2016: 5952165.
Jill P.G. Urban, Sally Roberts. Degeneration of the intervertebral disc. Arthritis Research & Therapy 2003, 5: 120-130.
Fujiwara A.; Tamai K.; An H.S.; Kurihashi T.; Lim T.H.; Yoshida H.; Saotome K. The relationship between disc degeneration, facet joint osteoarthritis, and stability of the degenerative lumbar spine.
J Spinal Disord. 2000, 13(5): 444-450.
Vernon-Roberts B.; Moore R.J.; Fraser R.D. The natural history of age-related disc degeneration: the pathology and sequelae of tears. Spine 2007, 32(25): 2797-2804.
Haefeli M.; Kalberer F.; Saegesser D.; Nerlich A.G.; Boos N.; Paesold G. The course of macroscopic degeneration in the human lumbar intervertebral disc. Spine 2006, 31(14): 1522-1531.
Inoue N.; Espinoza Orías A.A. Biomechanics of intervertebral disk degeneration. Orthop Clin North Am. 2011, 42(4): 487-499.
Lafian A.M.; Torralba K.D. Lumbar Spinal Stenosis in Older Adults in Older Adults. Rheum Dis Clin North Am. 2018, 44(3): 501-512.
Greenblatt M.B.; Tsai J.N.; Wein M.N. Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease. Clin Chem. 2017, 63(2): 464-474.
Vasikaran S.D.; Chubb S.P.; Ebeling P.R.; Jenkins N.; Jones G.R.; Kotowicz M.A.; Morris H.A.; Schneider H.G.; Seibel M.J.; Ward G. Harmonised Australian Reference Intervals for Serum PINP and CTX in Adults. Clin Biochem Rev. 2014, 35(4): 237-242.
Koivula M.K.; Risteli L.; Risteli J. Measurement of aminoterminal propeptide of type I procollagen (PINP) in serum. Clin Biochem Rev. 2012, 45(12): 920-927.
Mattias Lorentzon; Jaime Branco; Maria Luisa Brandi; Olivier Bruyère; Roland Chapurlat; Cyrus Cooper; Bernard Cortet; Adolfo Diez-Perez; Serge Ferrari; Andrea Gasparik; Markus Herrmann; Niklas Rye Jorgensen; John Kanis; Jean-Marc Kaufman; Andrea Laslop; Médéa Locquet; Radmila Matijevic; Eugene McCloskey; Salvatore Minisola; Richard Pikner; Jean-Yves Reginster; René Rizzoli; Pawel Szulc; Mila Vlaskovska; Etienne Cavalier. Algorithm for the Use of Biochemical Markers of Bone Turnover in the Diagnosis, Assessment and Follow-Up of Treatment for Osteoporosis. Adv Ther. 2019, 36(10): 2811-2824.
Andrzej Kutner; Geoffrey Brown. Vitamins D: Relationship between Structure and Biological Activity. Int J Mol Sci. 2018, 19(7): 2119.
Wiciński M.; Adamkiewicz D.; Adamkiewicz M.; Śniegocki M.; Podhorecka M.; Szychta P.; Malinowski B. Impact of Vitamin D on Physical Efficiency and Exercise Performance - A Review. Nutrients 2019, 11(11): 2826.
Hardcastle S.A.; Dieppe P.; Gregson C.L.; Davey Smith G.; Tobias J.H. Osteoarthritis and bone mineral density: are strong bones bad for joints? Bonekey Rep. 2015, 4: 624.
Clara Yongjoo Park. Vitamin D in the Prevention and Treatment of Osteoarthritis: From Clinical Interventions to Cellular Evidence. Nutrients 2019, 11(2): 243.
Goltzman D. Physiology of Parathyroid Hormone. Endocrinol Metab Clin North Am. 2018, 47(4): 743-758.
Lombardi G.; Di Somma C.; Rubino M.; Faggiano A.; Vuolo L.; Guerra E.; Contaldi P.; Savastano S.; Colao A. The roles of parathyroid hormone in bone remodeling: prospects for novel therapeutics.
J Endocrinol Invest. 2011, 34(7 Suppl): 18-22.
Zanocco K.A.; Yeh M.W. Primary Hyperparathyroidism: Effects on Bone Health. Endocrinol Metab Clin North Am. 2017, 46(1): 87-104.
Orwoll E.S.; Scheele W.H.; Paul S.; Adami S.; Syversen U.; Diez-Perez A.; Kaufman J.M.; Clancy A.D.; Gaich G.A. The effect of teriparatide [human parathyroid hormone (1-34)] therapy on bone density in men with osteoporosis. J Bone Miner Res. 2003, 18(1): 9-17.
Krege J.H.; Lane N.E.; Harris J.M.; Miller P.D. PINP as a biological response marker during teriparatide treatment for osteoporosis. Osteoporos Int. 2014, 25(9): 2159-2171.
Espanha M.M. Articular cartilage: structure and histochemical composition. Tissue Eng Part B Rev. 2010, 16(6): 617-627.
Responte D.J.; Natoli R.M.; Athanasiou K.A. Collagens of articular cartilage: structure, function, and importance in tissue engineering. Crit Rev Biomed Eng. 2007, 35(5): 363-411.
Posey K.L.; Coustry F.; Hecht J.T. Cartilage oligomeric matrix protein: COMPopathies and beyond: Matrix Biol. 2018, 71-72: 161-173.
Mingjian Huang; Jingyu Zhao; Yan Huang; Liming Dai; Xiaoling Zhang. Meta-analysis of urinary
C-terminal telopeptide of type II collagen as a biomarker in osteoarthritis diagnosis. J Orthop Translat. 2018, 13: 50-57.
Garnero P.; Piperno M.; Gineyts E.; Christgau S.; Delmas P.D.; Vignon E. Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis. 2001, 60(6): 619-626.
Pengkun Wang; Jinlong Song; Dongyang Qian. CTX-II and YKL-40 in early diagnosis and treatment evaluation of osteoarthritis. Exp Ther Med. 2019, 17(1): 423-431.
Young-Min S.A.; Cawston T.E.; Griffiths I.D. Markers of joint destructions: principles problems and potential. Ann Rheum Dis. 2001, 60(6): 545-548.
Garnero P.; Piperno M.; Gineyts E.; Christgau S.; Delmas P.D.; Vignon E. Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis. 2001, 60(6): 619-626.
Dragomir A.D.; Kraus V.B.; Renner J.B.; Luta G.; Clark A.; Vilim V.; Hochberg M.C.; Helmick C.G.; Jordan J.M. Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology. Osteoarthritis Cartilage. 2002, 10(9): 687-691.
Vilím V.; Olejárová M.; Machácek S.; Gatterová J.; Kraus V.B.; Pavelka K. Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis. Osteoarthritis Cartilage. 2002, 10(9): 707-713.
Garnero P.; Conrozier T.; Christgau S. Urinary type collagen C-propeptide levels in patients with rapidly destructive hip osteoarthritis. Ann. Rheum Dis. 2003, 62(10): 939-943.
Garnero P.; Ayral X.; Rousseau J.C.; Christgau S.; Sandell L.J.; Dougados M.; Delmas P.D. Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis. Arthritis Rheum. 2002, 46(10): 2613-2624.
Reijman M.; Hazes J.M.; Bierma-Zeinstra S.M.; Koes B.W.; Christgau S.; Christiansen C.; Uitterlinden A.G.; Pols H.A. A new marker of osteoarthritis: cross-selectional and longitudinal approach. Arthritis Rheum. 2004, 50(8): 2471-2478.
Garnero P.; Landewé R.; Boers M.; Verhoeven A.; Van Der Linden S.; Christgau S.; Van Der Heijde D.; Boonen A.; Geusens P. Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis: the COBRA study. Arthritis Rheum. 2002, 46(11): 2847-2856.
Jung M.; Christgau S.; Lukoschek M.; Henriksen D.; Richter W. Increased urinary concentration of collagen type II C-telopeptide fragments in patients with osteoarthritis. Pathobiology 2004, 71(2): 70-76.
Lohmander L.S.; Atley L.M.; Pietka T.A.; Eyre D.R. The release of cross-linked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis. Arthritis Rheum. 2003, 48(11): 3130-3139.
Holick M.F.; Chen T.C. Vitamin D deficiency: a worldwide problem with health consequences. Am
J Clin Nutr. 2008, 87(4): 1080-1086.
Pereira-Santos M.; Costa P.R.; Assis A.M.; Santos C.A.; Santos D.B. Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev. 2015, 16(4): 341-349.
Glover T.L.; Goodin B.R.; King C.D.; Sibille K.T.; Herbert M.S.; Sotolongo A.S.; Cruz-Almeida Y.; Bartley E.J.; Bulls H.W.; Horgas A.L.; Redden D.T.; Riley J.L. 3rd; Staud R.; Fessler B.J.; Bradley L.A.; Fillingim R.B. A Cross-sectional Examination of Vitamin D, Obesity, and Measures of Pain and Function in Middle-aged and Older Adults With Knee Osteoarthritis. Clin J Pain. 2015, 31(12): 1060-1067.
Zhang F.F.; Driban J.B.; Lo G.H.; Price L.L.; Booth S.; Eaton C.B.; Lu B.; Nevitt M.; Jackson B.; Garganta C.; Hochberg M.; Kwoh K.; McAlindon T.E. Vitamin D deficiency is associated with progression of knee osteoarthritis. J Nutr. 2014, 144(12): 2002-2008.
Kravets I. Paget's Disease of Bone: Diagnosis and Treatment. Am J Med. 2018, 131(11): 1298-1303.
Lyubimova N.V.; Pashkov M.V.; Tyulyandin S.A.; Gol'dberg V.E.; Kushlinskii N.E. Tartrate-resistant acid phosphatase as a marker of bone metastases in patients with breast cancer and prostate cancer. Bull Exp Biol Med. 2004, 138(1): 77-79.
Reithmeier A.; Norgard M.; Ek-Rylander B.; Näreoja T.; Andersson G. Cathepsin K regulates localization and secretion of Tartrate-Resistant Acid Phosphatase (TRAP) in TRAP – over expressing MDA-MB-231 breast cancer cells. BMC Mol Cell Biol. 2020, 21(1): 15.
J. Towheed T.; Welch V.; Wells G.; Tugwell P. American College of Rheumatology; Arthritis Care Res (Hoboken). 2012, 64(4): 465-474.
Holger Joswig; Martin N. Stienen; Nicolas R. Smoll; Marco V. Corniola; Ivan Chau; Karl Schaller; Gerhard Hildebrandt; Oliver P. Gautschi. Effects of Smoking on Subjective and Objective Measures of Pain Intensity, Functional Impairment, and Health-Related Quality of Life in Lumbar Degenerative Disk Disease. World Neurosurg. 2017, 99:6-13.
Vincent, H.K.; Heywood K.; Connelly J.; Hurley R.W. Obesity and Weight Loss in the treatment and prevention of osteoarthritis. PM R. 2012, 4(5 Suppl): 59-67.
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