Профилактика ожирения и неалкогольного стеатогепатита у крыс антидисбиотическим средством = Prevention and treatment effect of antidysbiotic formulation on obesity and nonalcoholic steatohepatitis in rats

Abstract

Levitsky A. P., Tkachuk V. V., Velichko V. I., Vasyuk V. L. Профилактика ожирения и неалкогольного стеатогепатита у крыс антидисбиотическим средством = Prevention and treatment effect of antidysbiotic formulation on obesity and nonalcoholic steatohepatitis in rats. Journal of Education, Health and Sport. 2016;6(4):281-286. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.50200

http://ojs.ukw.edu.pl/index.php/johs/article/view/3471

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).

755 Journal of Education, Health and Sport eISSN 2391-8306 7

© The Author (s) 2016;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,

provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License

(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 20.03.2016. Revised 17.04.2016. Accepted: 17.04.2016.

УДК 517.112:612.8+615.462

ПРОФИЛАКТИКА ОЖИРЕНИЯ И НЕАЛКОГОЛЬНОГО СТЕАТОГЕПАТИТА У КРЫС АНТИДИСБИОТИЧЕСКИМ СРЕДСТВОМ

А. П. Левицкий¹, В. В. Ткачук², В. И. Величко², В. Л. Васюк³

¹ГУ «Институт стоматологии НАМН Украины» (г. Одесса, Украина)

e-mail: flavan@mail.ru

²Одесский национальный медицинский университет (Украина)

³Буковинский государственный медицинский университет (г. Черновцы, Украина)

 Резюме

Сочетание высокожирового рациона и кишечного дисбиоза вызывает у крыс развитие ожирения и неалкогольного стеатогепатита (НАСГ). Введение антидисбиотического средства «Квертулин» (кверцетин + инулин + цитрат кальция) предотвращает развитие ожирения и НАСГ.

Ключевые слова: ожирение, неалкогольный стеатогепатит, липиды, высокожировое питание, дисбиоз, антидисбиотическое средство.

PREVENTION AND TREATMENT EFFECT OF ANTIDYSBIOTIC FORMULATION ON OBESITY AND NONALCOHOLIC STEATOHEPATITIS IN RATS

A. P. Levitsky¹, V. V. Tkachuk²,V. I. Velichko², V. L. Vasyuk³

¹SE«The Institute of Stomatology of the National academie of medical science of Ukraine» (Odessa, Ukraine) e-mail: flavan@mail.ru

²Odessa National Medical University (Ukraine)

³Bukovina State Medical University (Chernovtsy, Ukraine)

Abstract

Aim: To determine of prevention and treatment effect of antidysbiotic formulation on obesity and NASH in rats.

Methods: The experimental obesity and NASH were induced by feeding rats with a high fat diet (HFD) (fodder, plus 15 % sunflower oil – 40 days) and driaking water with lincomycin at a dose of 60 mg/kg day for 5 days. The duration of experiment was 41 days. One group of rats received HFD and lincomycin, received antidysbiotic formulation Quertulin (quercetine + inuline + Ca-citrate) in dose 300 mg/kg 40 days. Determined morphometric parameters like body mass, body mass index, content of triglyceride (TG) and cholesterine (Ch) of liver and serum cjntent of bilirubine and activity of ALT and in serum, alkaline phosphatase (AP).

Results: At obesity and NASH body mass, body mass index, content of TR, Ch, in liver and serum were increased; in serum content to bilirubine and activity to ALT and AP were increased. Taking quertulin normalized morphometric and biochemic indexis in liver and serum.

Conclusion: Antidysbiotic formulation quertulin made of prevention and treatment effect on obesity and NASH.

Key words: obesity, nonalcoholic steatohepatitis, lipids, high fat nutrition, dysbiosis, antidysbiotic formulation.