Пародонтопротекторное действие антидисбиотических средств при экспериментальном сахарном диабете 2 типа = Periodontitis-protective effecr of anti-dysbiotic means at experimental diabetes mellitus type 2

Abstract

Stupak E. P., Skidan K. V., Skidan M. I., Dem'yanenko S. A. Пародонтопротекторное действие антидисбиотических средств при экспериментальном сахарном диабете 2 типа = Periodontitis-protective effecr of anti-dysbiotic means at experimental diabetes mellitus type 2. Journal of Education, Health and Sport. 2015;5(12):588-597. eISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.44264

http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2812%29%3A588-597

http://pbn.nauka.gov.pl/works/687233

Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport (null) 2391-8306 7

© The Author (s) 2015;

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 10.12.2015. Revised 15.12.2015. Accepted: 29.12.2015.

УДК 616.731-07.23.008

ПАРОДОНТОПРОТЕКТОРНОЕ ДЕЙСТВИЕ АНТИДИСБИОТИЧЕСКИХ СРЕДСТВ ПРИ ЭКСПЕРИМЕНТАЛЬНОМ САХАРНОМ ДИАБЕТЕ 2 ТИПА

PERIODONTITIS-PROTECTIVE EFFECR OF ANTI-DYSBIOTIC MEANS AT EXPERIMENTAL DIABETES MELLITUS TYPE 2

Е. П. Ступак¹, К. В. Скидан², М. И. Скидан², С. А. Демьяненко³

E. P. Stupak¹, K. V. Skidan², M. I. Skidan², S. A. Dem'yanenko³

¹ВГУУ «Украинская медицинская стоматологическая академия», г. Полтава

²Харьковский национальный медицинский университет

³Крымский государственный медицинский университет
им. С. И. Георгиевского, г. Симферополь

¹HSEI «Ukrainian medical Stomatological Academy», Poltava

²Kharkiv national medical university, Kharkiv

³Crimean State Medical University named after S.I.Georgievskij, Simferopol

Abstract

Aim: To determine the therapeutic and preventive effect of oral gels with anti-dysbiotic means (ADM) on periodont at type 2 diabetes mellitus (DMT2).

Materials and Methods: Diabetes in rats was induced by an intra-muscular administration of protamine sulfate for 10 days. As ADM there were used lysozyme, quercetin, flour, mucosin and flour from vine leaves, which were applied in form of gels on the oral mucosa of rats for 2 weeks. In the gums' homogenates there were determined the activities of urease, lysozyme, elastase, catalase and the MDA content. The degree of dysbiosis by Levitsky was calculated as the ratio of the relative activities of urease and lysozyme. The antioxidant-prooxidant index API was calculated as the ratio of the catalase activity and the MDA content.

Results: The urease activity, the degree of dysbiosis, the elastase activity and the MDA content were increased while the lysozyme activity and the index API were reduced in rats with diabetes type 2 in the periodont. Applied gels containing ADM showed therapeutic and preventive effects.

Conclusion: At diabetes type 2 in the periodont of rats there were developing dysbiosis and inflammation. The application of oral gels with ADM provided a therapeutic and preventive treatment.

Keywords: diabetes type 2, periodont, dysbiosis, inflammation, anti-dysbiotic means, oral gels.

Резюме

При экспериментальном сахарном диабете 2 типа в десне развивается дисбиоз и воспаление. Оральные гели с антидисбиотическими средствами (лизоцим, кверцетин, мукозин и мука из виноградных листьев) оказывают лечебно-профилактический эффект.

Ключевые слова: сахарный диабет 2 типа, пародонт, дисбиоз, воспаление, антидисбиотические средства, оральные гели.