MORPHOLOGICAL CHANGES OF THE SKIN IN A POSTOPERATIVE WOUND AT THE SYNDROME OF OPIOID-INDUCED HYPERALGESIA
Keywordsanalgesia, hyperalgesia, skin biopsy.
Dmytriiev D. V. Morphological changes of the skin in a postoperative wound at the syndrome of opioid-induced hyperalgesia. Journal of Education, Health and Sport. 2015;5(12):262-270. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.35417
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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 10.11.2015. Revised 25.11.2015. Accepted: 14.12.2015.
Morphological changes of the skin in a postoperative wound at the syndrome of opioid-induced hyperalgesia
D. V. Dmytriiev
Vinnytsya National Pirogov Memorial Medical University
Department of anesthesiology and intensive care
The article describes the morphological changes of the skin in the area of postoperative wound. It has been found that the use of high doses of fentanyl (10-20 mcg/kg/hr) by continuous infusion for analgesia in the early postoperative period in children operated on for tumors of abdominal cavity can cause opioid-induced hyperalgesia, which is accompanied by morphological changes in the skin around the postoperative wound with the development of necrosis in the center of it, with expressed perifocal reactive changes in the form of significant inflammation and violations of microcirculation with the formation of the small nerve fibers on the 14th day. There was fibrosis of the derma with the formation of large amount of collagen fibers with their edema and lamination.
Key words: analgesia, hyperalgesia, skin biopsy.
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