ENDOGENEOUS INTOXICATION IN PATIENTS WITH COMBINED THORACIC TRAUMA DURING EARLY POSTTRAUMATIC PERIOD

Abstract

Stupnytskyi M. A. Endogeneous intoxication in patients with combined thoracic trauma during early posttraumatic period. Journal of Education, Health and Sport. 2015;5(12):23-30. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.34596

http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2812%29%3A23-30

Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive

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© The Author (s) 2015;

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 25.09.2015. Revised 25.10.2015. Accepted: 30.11.2015.

ENDOGENEOUS INTOXICATION IN PATIENTS WITH COMBINED THORACIC TRAUMA DURING EARLY POSTTRAUMATIC PERIOD

M. A. Stupnytskyi

Biochemistry Department, Kharkiv National Medical University, Kharkiv, Ukraine

Myroslav Stupnytskyi

stupnytskyima@gmail.com

Abstract. The aim of the study was to investigate the dynamic of the endotoxemia markers' plasmatic concentrations and the possibility of using them for outcome prediction in patients with the severe combined chest trauma during early posttraumatic period. Study was performed on 73 male patients aged from 20 to 68. The concentrations of oxidative stress markers do not represent the activity of oxidative processes in case of massive infusion therapy especially on 1-2-d day after trauma. The level of the medium-sized peptides fractions concentrations can reflect severity of endotoxemia better than routine clinical markers (urea and creatinine) and can serve as additional markers for outcome prediction in patients with the severe combined thoracic trauma. The severity of injury and the level of traumatic shock leads to proportional accumulation of the peptide fraction of the medium-sized peptides up to 5-6-th day after trauma.

Key words: chest trauma, polytrauma, endogenous intoxication, oxidative stress, wound dystrophy.