PARODONT-PROTECTIVE ACTION OF ORAL GEL "ARGININE" APPLICATIONS IN RATS WITH INTESTINAL DYSBIOSIS WHICH RECEIVED A HIGH-FAT DIET

Abstract

Borisenko A. V., Levitsky A. P., Kuvaev A. S. Пародонтопротекторное действие оральных аппликаций геля «Аргинин» у крыс с кишечным дисбиозом, получавших высокожировой рацион = Parodont-protective action of oral gel "Arginine" applications in rats with intestinal dysbiosis which received a high-fat diet. Journal of Education, Health and Sport. 2015;5(3):294-302. ISSN 2391-8306. DOI: 10.5281/zenodo.16495

http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%283%29%3A294-302

https://pbn.nauka.gov.pl/works/552270

http://dx.doi.org/10.5281/zenodo.16495

Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 20.01.2014. Revised 27.02.2015. Accepted: 12.03.2015.

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ПАРОДОНТОПРОТЕКТОРНОЕ ДЕЙСТВИЕ ОРАЛЬНЫХ АППЛИКАЦИЙ ГЕЛЯ «АРГИНИН» У КРЫС С КИШЕЧНЫМ ДИСБИОЗОМ, ПОЛУЧАВШИХ ВЫСОКОЖИРОВОЙ РАЦИОН

Parodont-protective action of oral gel "ARGININE" applications in rats with intestinal dysbiosis which received a high-fat diet

А. В. Борисенко¹, А. П. Левицкий², А. С. Куваев¹

A. V. Borisenko, A. P. Levitsky, A. S. Kuvaev

¹Киевский национальный медицинский университет им. А. А. Богомольца

²ГУ «Институт стоматологии НАМН» (г. Одесса)

¹National Medical University named after А. А. Bogomolets, Kiyv

²SE “The Institute of Stomatology of the NAMS of Ukraine” (Odessa, Ukraine)

Abstract

Aim: To determine the periodontal condition at intestinal dysbiosis and high-fat diet (HFD) and the influence of an oral gel containing arginine.

Materials and methods: We used a mucous-adhesive phytogel containing cardioarginin (14% on a 4% CMC). Intestinal dysbiosis was obtained using lincomycin (60 mg/kg). HFD was prepared by addition of palm oil to the feed (final fat content in the diet 25%). Dysbiosis was calculated according to the levels of urease and lysozyme, inflammation was expressed in terms of inflammatory markers (MDA and elastase). In the gums there were determined the content of hyaluronic acid and the degree of atrophy of periodontal by Nikolaeva. Gel applications were performed at the dose 0.3 ml / rat daily.

Results: Intestinal dysbiosis on the HFD background causes in the development of periodontal dysbiosis, inflammation and tissue recession. Oral gels containing arginine have parodont-protective action.

Key words: periodontal, dysbiosis, fatty food, inflammation, arginine, oral gels.

Реферат

При воспроизведении кишечного дисбиоза на фоне высокожирового рациона в пародонте крыс развивается дисбиоз, воспаление и рецессия тканей. Оральные аппликации геля, содержащего аргинин, оказывают пародонтопротекторное действие, что свидетельствует о важной защитной роли окиси азота, образующейся из аргинина.

Ключевые слова: пародонт, дисбиоз, жировое питание, воспаление, аргинин, оральные гели.

ьные гели.