Natural or synthetic? Phytotherapy and phytochemistry as the inspiration for organic synthesis of natural compounds
DOI:
https://doi.org/10.12775/HERB.2020.001Keywords
phytochemistry, bioactive compounds, menthol, salicin, hypericin, 1-DNJAbstract
Majority of synthetic drugs used by contemporary medicine originate from substances
present in plants. However, natural sources of herbal drugs are being erratic, culti-
vated medicinal plants also face climate change, whereas the demand for bioactive
compounds and plant extracts is on the increase. Rational phytotherapy applies
preparations with well identied active components, whose pharmacological Majority of synthetic drugs used by contemporary medicine originate from substances present in plants. However, natural sources of herbal drugs are being erratic, cultivated medicinal plants also face climate change, whereas the demand for bioactive compounds and plant extracts is on the increase. Rational phytotherapy applies preparations with well identied active components, whose pharmacological efficiency has been proved by clinical tests. To perform the studies in vivo using animals and for clinical tests signicant amounts of bioactive compounds are required. The compounds and plants of interest include menthol, main component of Peppermint oil, salicin from Willow bark and 1-deoxynojirimycin from Morus alba. ese compounds can be isolated in small amounts from herbs, but the methods of their total organic synthesis should be developed. It is an inspiration for chemists and first step towards industrial production
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