Radioprotekcyjne właściwości ekstraktów z kory sosny
DOI:
https://doi.org/10.12775/HERB.2022.005Klíčová slova
radioprotekcja, technet, komórki GMK, Pinus silvestris, kora sosny zwyczajnejAbstrakt
Zbadano przeżywalność komórek nerek zielonej małpy (GMK) poddanych rosnącym dawkom promieniowania γ. Do hodowli komórek dodano kompleks 99mTcDMSA (technetu 99mTc z kwasem merkaptobursztynowym, DMSA). Rozmiary zmian post-radiacyjnych oszacowano na podstawie liczenia komórek. Dodanie ekstraktów z kory zwiększyło przeżywalność komórek, w porównaniu do grupy bez dodatku radioizotopu, a zwłaszcza potraktowanej technetem bez środków ochronnych. Badania ekstraktów z sosny zwyczajnej Pinus silvestris i Pinus maritina (Pyc-
nogenol) metodą EPR pokazały, że oba są efektywne w zmiataniu rodnika DPPH. Sugerowany mechanizm radioprotekcyjny obejmuje działanie antyoksydacyjne i przeciwrodnikowe.
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