Lecznicze właściwości Cynara scolymus? Krytyczny przegląd dowodów i molekularnych mechanizmów działania
DOI:
https://doi.org/10.12775/HERB.2024.008Ključne riječi
karczoch zwyczajny (Cynara scolymus), polifenole, terpenoidy, hipercholesterolemia, dyspepsja czynnościowa, niealkoholowe stłuszczenie wątrobySažetak
Karczoch zwyczajny (Cynara scolymus) jest znany za sprawą dużej zawartości aktywnych biologicznie metabolitów: polifenoli oraz terpenoidów. Przypisuje im się działanie hipolipidemiczne, antydyspeptyczne, hepatoprotekcyjne oraz antyoksydacyjne. Mimo to liczba dobrej jakości badań klinicznych dokumentujących działanie lecznicze karczocha i ekstraktu z jego liści (ELK) jest stosunkowo niewielka. Zgromadzone w nich dowody zdają się potwierdzać pozytywny wpływ ELK w hipercholesterolemii i dyspepsji czynnościowej. Sugerują też możliwy efekt terapeutyczny u chorych na niealkoholowe stłuszczeniowe zapalenie wątroby i zespół jelita drażliwego. We wszystkich tych przypadkach potrzebne są dalsze rygorystyczne
badania kliniczne, które pozwolą skwantykować obserwowane efekty i dawki ELK konieczne do ich wywołania. Dowody zdają się wykluczać jakiekolwiek działanie ELK w leczeniu wirusowego zapalenia wątroby typu C oraz kaca alkoholowego.
References
The Royal Botanic Gardens, Kew, Harvard University Herbaria & Libraries and Australian National Herbarium, IPNI – International Plant Names Index 2023, 2023, https://www.ipni.org/ (dostęp 25.11.2023).
Sonnante G., Pignone D., Hammer K., The domestication of artichoke and cardoon: From Roman times to the genomic age, Annals of Botany, 2007, 100, s. 1095–1100.
US Department of Health and Human Services, National Institutes of Health, Office of Dietary Supplements, DSDL – Dietary Supplement Label Database, 2023, https://dsld.nlm.nih.gov/dsld/ (dostęp 25.11.2023).
Wang M., Simon J.E., Aviles I.F., He K., Zheng Q.Y., Tadmor Y., Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.), Journal of Agricultural and Food Chemistry, 2003, 51, s. 601–608.
Negro D., Montesano V., Grieco S., Crupi P., Sarli G., De Lisi A., Sonnate G., Polyphenol Compounds in Artichoke Plant Tissues and Varieties, Journal of Food Science, 2012, 77, s. 244–252.
Shimoda H., Ninomiya K., Nishida N., Yoshino T., Morikawa T., Matsuda H., Yoshikawa M., Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): Structure requirement and mode of action, Bioorganic and Medicinal Chemistry Letters, 2003, 13, s. 223–228.
Fritsche J., Beindorff C.M., Dachtler M., Zhang H., Lammers J.G., Isolation, characterization and determination of minor artichoke (Cynara scolymus L.) leaf extract compounds, European Food Research and Technology, 2002, 215, s. 149–157.
Mach F., Catapano A., Baigent C., Wiklund O., Wytyczne ESC/EAS dotyczące postępowania w dyslipidemiach: jak dzięki leczeniu zaburzeń lipidowych obniżyć ryzyko sercowo-naczyniowe (2019), Kardiologia Polska, 2020, 78, s. 12–103.
Piwońska A., Piotrowski W., Kozela M., Pająk A., Nadrowski P., Kozakiewicz K., Tykarski A., Bielecki W., Puch-Walczak A., Zdrojewski T., Drygas W., Cardiovascular diseases prevention in Poland: Results of WOBASZ and WOBASZ II studies, Kardiologia Polska, 2018, 76, s. 1543–1541.
Englisch W., Beckers C., Unkauf M., Ruepp M., Zinserling V., Efficacy of artichoke dry extract in patients with hyperlipoproteinemia, Drug Research, 2000, 50, s. 260–265.
Bundy R., Walker A.F., Middleton R.W., Wallis C., Simpson H.C.R., Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: A randomized, double blind placebo controlled trial, Phytomedicine, 2008, 15, s. 668–675.
Rondanelli M., Giacosa A., Opizzi A., Faliva M.A., Sala P., Perna S., Riva A., Morazzoni P., Bombardelli E., Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: A double-blind, randomized, placebo-controlled trial, International Journal of Food Sciences and Nutrition, 2013, 64, s. 7–15.
Gebhardt R., Inhibition of Cholesterol Biosynthesis in Primary Cultured Rat Hepatocytes by Artichoke (Cynara scolymus L.) Extracts, Journal of Pharmacology and Experimental Therapeutics, 1998, 268, s. 1122–1128.
Gebhardt R., Inhibition of cholesterol biosynthesis in HepG2 cells by artichoke extracts is reinforced by glucosidase pretreatment, Phytotherapy Research, 2002, 16, s. 368–372.
Stancu C., Sima A., Statins: Mechanism of action and effects, Journal of Cellular and Molecular Medicine, 2001, 5, s. 378–387.
Wider B., Pittler M.H., Thompson-Coon J., Ernst E., Artichoke leaf extract for treating hypercholesterolaemia, Cochrane Database of Systematic Reviews, 2016, 3.
Mulak A., Freud T., Waluga M., Bangdiwala S.I., Palsson O.S., Sperber A.D., Sex- and gender-related differences in the prevalence and burden of disorders of gut–brain interaction in Poland, Neurogastroenterology and Motility, 2023, 35, e14568.
Tack J., Talley N.J., Functional dyspepsia – Symptoms, definitions and validity of the Rome III criteria, Nature Reviews Gastroenterology and Hepatology, 2013, 10, s. 134–141.
Ford A.C., Mahadeva S., Carbone M.F., Lacy B.E., Talley N.J., Functional dyspepsia, The Lancet, 2020, 396, s. 1689–1702.
Holtmann G., Adam B., Haag S., Collet W., Grünewald E., Windeck T., Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: A six-week placebo-controlled, double-blind, multicentre trial, Alimentary Pharmacology and Therapeutics, 2003, 18, s. 1099–1105.
Marakis G., Walker A.F., Middleton R.W., Booth J.C.L., Wright J., Pike D.J., Artichoke leaf extract reduces mild dyspepsia in an open study, Phytomedicine, 2002, 9, s. 694–699.
Kirchhoff R., Beckers C., Kirchhoff G.M., Trinczek-Gärtner H., Petrowicz O., Reimann H.J., Increase in choleresis by means of artichoke extract, Phytomedicine, 1994, 1, s. 107–115.
Preziosi P., Loscalzo B., Marmo E., Comparison of choleretic effects of CYN and Nadehydrocholate, Experientia, 1959, 15, s. 135–138.
Gebhardt R., Choleretic and anticholestatic activities of flavonoids of artichoke (Cynara cardunculus L. subsp. scolymus (L.) Hayek), Acta Horticulturae, 2005, 681, s. 429–436.
Maciejewska D., Stachowska E., Non-alcoholic fatty liver disease (NAFLD) – Epidemic of the XXI century, Postępy Higieny i Medycyny Doświadczalnej, 2018, 72, s. 659–670.
Bondini S., Kleiner D.E., Goodman Z.D., Gramlich T., Younossi Z.M., Pathologic Assessment of Non-alcoholic Fatty Liver Disease, Clinics in Liver Disease, 2007, 11, s. 17–23.
Nikolopoulos A., Oben J., Non-Alcoholic Fatty Liver Disease w Liver Diseases: An Essential Guide for Nurses and Health Care Professionals, (red.) S. Sargent, John Wiley & Sons, 2009.
Rinella M.E., Nonalcoholic fatty liver disease: a systematic review, JAMA – Journal of the American Medical Association, 2015, 313, s. 2263–2273.
Panahi Y., Kianpour P., Mohtashami R., Atkin S.L., Butler A.E., Jafari R., Badeli R., Sahebkar A., Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial, Phytotherapy Research, 2018, 32, s. 1382–1387.
Amini M.R., Sheikhhossein F., Talebyan A., Bazshahi E., Djafari F., Hekmatdoost A., Effects of Artichoke Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Clinical Nutrition Research, 2022, 11, s. 228–239.
Rangboo V., Noroozi M., Zavoshy R., Rezadoost S.A., Mohammadpoorasl A., The Effect of Artichoke Leaf Extract on Alanine Aminotransferase and Aspartate Aminotransferase in the Patients with Nonalcoholic Steatohepatitis, International Journal of Hepatology, 2016.
Salem M., Ksouda K., Dhouibi R., Charfi S., Turki M., Hammami S., Ayedi F., Sahnoun Z., Zeghal K.M., Affes H., LC-MS/MS Analysis and Hepatoprotective Activity of Artichoke (Cynara scolymus L.) Leaves Extract against High Fat Diet-Induced Obesity in Rats, BioMed Research International, 2019.
Wauquier F., Boutin-Wittrant L., Viret A., Guilhaudis L., Oulyadi H., Bourafai-Aziez A., Charpentier G., Rousselot G., Cassin E., Descamps S., Roux V., Macian N., Pickering G., Wittrant Y., Metabolic and anti-inflammatory protective properties of human enriched serum following artichoke leaf extract absorption: Results from an innovative ex vivo clinical trial, Nutrients, 2021, 13 , s. 2653.
Adrych K., Zespół jelita drażliwego w świetle najnowszych wytycznych, Forum Medycyny Rodzinnej, 2018, 12, s. 224–233.
Bundy R., Walker A.F., Middleton R.W., Marakis G., Booth J.C.L., Artichoke leaf extract reduces symptoms of irritable bowel syndrome and improves quality of life in otherwise healthy volunteers suffering from concomitant dyspepsia: A subset analysis, Journal of Alternative and Complementary Medicine, 2004, 10, s. 667–669.
Walker A.F., Middleton R.W., Petrowicz O., Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study, Phytotherapy Research, 2001, 15, s. 58–61.
Wang L.S., D’Souza L.S., Jacobson I.M., Hepatitis C – A clinical review, Journal of Medical Virology, 2016, 88, s. 1844–1855.
Huber R., Müller M., Naumann J., Schenk T., Lüdtke R., Artichoke leave extract for chronic hepatitis C – A pilot study, Phytomedicine, 2009, 16, s. 801–804.
Wiese J.G., Shlipak M.G., Browner W.S., The alcohol hangover, Annals of Internal Medicine, 2000, 132, s. 897–902.
Pittler M.H., White A.R., Stevinson C., Ernst E., Effectiveness of artichoke extract in preventing alcohol-induced hangovers: A randomized controlled trial, CMAJ, Canadian Medical Association Journal, 2003, 169, s. 1269–1273.
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