Muscle dysfunction during physical activity – muscle rhabdomyolysis

Katarzyna Żołądkiewicz, Łukasz Pabianek, Łukasz Jaśkiewicz, Paulina Brzezińska



Rhabdomyolysis is the breakdown of striated muscle fibers, which results in the release of muscle cell components into the peripheral circulation. Most cases of rhabdomyolysis are the result of trauma, often a consequence of seizures, alcohol and drug abuse but in some cases it is associated with very intensive physical activity. Proper understanding of muscle rhabdomyolysis can contribute to better preparation of sportsman for the intensive physical activity and to protect his body from episodes of extensive muscle breakdown and prevent their occurrence.

            This article is an attempted to summarize and show medical and biochemical basics of muscle rhabdomyolysis with a special attention to the episodes that occurs during physical activity. It may help in prevention of such cases in the future and protects the body of a sportsmen.


rhabdomyolysis, physical activity, myoglobin, muscle

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Abraham, R. B., Cahana, A., Krivosic-Horber, R. M., & Perel, A. (1997). Malignant hyperthermia susceptibility: anaesthetic implications and risk stratification. QJM: An International Journal of Medicine, 90(1), 13-18.

Aleckovic-Halilovic, M., Pjanic, M., Mesic, E., Storrar, J., Woywodt, A. (2020). From quail to earthquakes and human conflict: a historical perspective of rhabdomyolysis. Clinical Kidney Journal.

Bransford, D. R., Howley, E. T. (1977). Oxygen cost of running in trained and untrained men and women. Medicine and science in sports, 9(1), 41-44.

Brodal, P., Ingjer, F., Hermansen, L. (1977). Capillary supply of skeletal muscle fibers in untrained and endurance-trained men. American Journal of Physiology-Heart and Circulatory Physiology, 232(6), H705-H712.

Brodthagen U.A., Hansen K.N., Knudsen J.B., Jordal R., Kris-Tensen 0., Paulev P.E. (1985). Red cell 2,3-DPG, ATP, and mean cell volume in highly trained athletes. Eur J App! Physiol 53:334—338.

Brumback, R. A., Leech, R. W., Feeback, D. L. (1992). Rhabdomyolysis in childhood: A primer on normal muscle function and selected metabolic myopathies characterized by disordered energy production. Pediatric Clinics of North America, 39(4), 821-858.

Byrne, Eston, Twist (2004) Sports Medicine · February 2004 Neuromuscular Function After Exercise-Induced Muscle Damage DOI: 10.2165/00007256-200434010-00005 · Source: PubMed

Convertino, V. A., Brock, P. J., Keil, L. C., Bernauer, E. M., & Greenleaf, J. E. (1980). Exercise training-induced hypervolemia: role of plasma albumin, renin, and vasopressin. Journal of Applied Physiology, 48(4), 665-669.

Del Coso J, Ferna´ndez D, Abia´n-Vicen J, Salinero JJ, Gonza´lez-Milla´n C, et al. (2013) Running Pace Decrease during a Marathon Is Positively Related to Blood Markers of Muscle Damage. PLoS ONE 8(2): e57602. doi: 10.1371/journal.pone.0057602

Ekinci Akdemir, F. N., Gülçin, İ., Karagöz, B., & Soslu, R. (2016). Quercetin protects rat skeletal muscle from ischemia reperfusion injury. Journal of enzyme inhibition and medicinal chemistry, 31(sup2), 162-166.

Hikida RS, Staron RS, Hagerman FC, Sherman WM, Costill DL (1983) Muscle fiber necrosis associated with human marathon runners. J Neurol Sci 59: 185–203.

James, D. E., Kraegen, E. W., Chisholm, D. J. (1985). Effects of exercise training on in vivo insulin action in individual tissues of the rat. The Journal of clinical investigation, 76(2), 657-666.

Kendall, B., Eston, R. (2002). Exercise-induced muscle damage and the potential protective role of estrogen. Sports medicine, 32(2), 103-123.

Kimura, I., Ichimura, A., Ohue-Kitano, R., Igarashi, M. (2020). Free fatty acid receptors in health and disease. Physiological reviews, 100(1), 171-210.

Knochel (1990) Kidney International, Vol. 38 (1990), PP. 709—719, Catastrophic medical events with exhaustive exercise: "White collar rhabdomyolysis”

Kreider, R. B. (1998). Creatine supplementation: analysis of ergogenic value, medical safety, and concerns. J Exerc Physiol Online, 1.

Lameire, N., Matthys, E., Vanholder, R., De Keyser, K., Pauwels, W., Nachtergaele, L., & Ringoir, S. (1987). Causes and prognosis of acute renal failure in elderly patients. Nephrology Dialysis Transplantation, 2(5), 316-322.

Mondon, C. E., Dolkas, C. B., & Reaven, G. M. (1980). Site of enhanced insulin sensitivity in exercise-trained rats at rest. American Journal of Physiology-Endocrinology And Metabolism, 239(3), E169-E177.

Newham, D. J., Jones, D. A., Edwards, R. H. T. (1983). Large delayed plasma creatine kinase changes after stepping exercise. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine, 6(5), 380-385.

Nicholson, G. A., Morgan, G. J., Meerkin, M., Strauss, E. R., McLeod, J. G. (1986). The effect of aerobic exercise on serum creatine kinase activities. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine, 9(9), 820-824.

Poels, P. J. E., & Gabreels, F. J. M. (1993). Rhabdomyolysis: a review of the literature. Clinical neurology and neurosurgery, 95(3), 175-192.

Pugh, J. N., Sparks, A. S., Doran, D. A., Fleming, S. C., Langan-Evans, C., Kirk, B., ... & Close, G. L. (2019). Four weeks of probiotic supplementation reduces GI symptoms during a marathon race. European journal of applied physiology, 119(7), 1491-1501.

Rogers, M. A., Stull, G. A., & Apple, F. S. (1985). Creatine kinase isoenzyme activities in men and women following a marathon race. Medicine and Science in Sports and Exercise, 17(6), 679-682.

Rowell, L. B., Saltin, B., Kiens, B., Christensen, N. J. (1986). Is peak quadriceps blood flow in humans even higher during exercise with hypoxemia?. American Journal of Physiology-Heart and Circulatory Physiology, 251(5), H1038-H1044.

Schiff HB, MacSearraigh ET, Kallmeyer JC (1978) Myoglobinuria, rhabdomyolysis and marathon running. Q J Med 47: 463–472.

Shumate, J. B., Brooke, M. H., Carroll, J. E., & Davis, J. E. (1979). Increased serum creatine kinase after exercise: A sex‐linked phenomenon. Neurology, 29(6), 902-902.

Wong, Yeung (2001) Hong Kong Journal of Medicine 2001;8:38-39, Rhabdomyolysis after marathon run.

Zager, R. A. (1996). Rhabdomyolysis and myohemoglobinuric acute renal failure. Kidney international, 49(2), 314-326.

Zierler, K., Rogus, E. M. (1980). Hyperpolarization as a mediator of insulin action: increased muscle glucose uptake induced electrically. American Journal of Physiology-Endocrinology And Metabolism, 239(1), E21-E29.

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The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

e-ISSN: 2450-3118
Numer DOI: 10.12775/QS

Action funded by the Ministry of Science and Higher Education under the contract number 916/P-DUN/2019 by funds dedicated to dissemination of research findings. Name of action: "Preparing for publication papers in English in 8 issues of the journal Quality in Sport in 2019-2020: Vol. 5, No. 1-4 (2019), Vol. 6, No. 1-4 (2020)".

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