Passiflora incarnata as an Adjunctive Treatment for Anxiety and Sleep Disorders
DOI:
https://doi.org/10.12775/QS.2024.35.56361Keywords
Passiflora Incarnata, Anxiety, sleep, depressionAbstract
Background: Passiflora incarnata (commonly known as passionflower) has a longstanding history in ethnopharmacology for its sedative and anxiolytic properties. Recent scientific advancements have expanded its applications, particularly in managing neuropsychiatric disorders such as anxiety, depression, and sleep disturbances.
Objective: This review synthesizes current evidence regarding the pharmacological mechanisms, clinical applications, and safety profile of Passiflora incarnata in neuropsychiatric contexts.
Methods: A systematic search of peer-reviewed literature from 2016 to 2024 was conducted to assess preclinical and clinical studies investigating the therapeutic potential of Passiflora incarnata.
Results: The review identified significant evidence supporting its anxiolytic, sedative, and antidepressant properties, mediated through GABAergic modulation, serotonergic pathways, and other neurochemical mechanisms. Clinical trials demonstrated efficacy in managing perioperative anxiety, sleep disturbances, and benzodiazepine tapering. Its safety profile was favorable, with minimal adverse effects reported.
Conclusion: Passiflora incarnata offers a promising herbal alternative or adjunct in the treatment of neuropsychiatric disorders, though further high-quality research is required to standardize its use.
References
Janda, K., Wojtkowska, K., Jakubczyk, K., Antoniewicz, J., & Skonieczna-Żydecka, K. (2020). Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review. Nutrients, 12(12), 3894. https://doi.org/10.3390/nu12123894
Farah Al-Mamoori,et al. Beneficial Neuro-Pharmacological Effect of Passion Flower (Passiflora Incarnate L). ARC Journal of Neuroscience. 2019; 4(1):22-26. http://dx.doi.org/10.20431/2456-057X.0401003
da Fonseca, L. R., Rodrigues, R. A., Ramos, A. S., da Cruz, J. D., Ferreira, J. L. P., Silva, J. R. A., & Amaral, A. C. F. (2020). Herbal Medicinal Products from Passiflora for Anxiety: An Unexploited Potential. TheScientificWorldJournal, 2020, 6598434. https://doi.org/10.1155/2020/6598434
Miroddi, M., Calapai, G., Navarra, M., Minciullo, P. L., & Gangemi, S. (2013). Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials. Journal of ethnopharmacology, 150(3), 791–804. https://doi.org/10.1016/j.jep.2013.09.047
Hou, X. J., Zhao, F., Wang, C. D., Liu, J. L., Zhang, R., Zhu, Y. L., Wang, C., Wang, L. Y., & Zhang, J. J. (2021). Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 46(8), 1943–1950. https://doi.org/10.19540/j.cnki.cjcmm.20200915.401
Christoffoli, M. T., Bachesk, A. B., Farah, G. J., & Ferreira, G. Z. (2021). Assessment of Passiflora incarnata L for conscious sedation of patients during the extraction of mandibular third molars: a randomized, split-mouth, double-blind, crossover study. Quintessence international (Berlin, Germany : 1985), 52(10), 868–878. https://doi.org/10.3290/j.qi.b1492199
Rodríguez-Landa, J. F., German-Ponciano, L. J., Puga-Olguín, A., & Olmos-Vázquez, O. J. (2022). Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin. Molecules (Basel, Switzerland), 27(11), 3551. https://doi.org/10.3390/molecules27113551
Nawrot, J., Gornowicz-Porowska, J., Budzianowski, J., Nowak, G., Schroeder, G., & Kurczewska, J. (2022). Medicinal Herbs in the Relief of Neurological, Cardiovascular, and Respiratory Symptoms after COVID-19 Infection A Literature Review. Cells, 11(12), 1897. https://doi.org/10.3390/cells11121897
Zanardi, R., Carminati, M., Fazio, V., Maccario, M., Verri, G., & Colombo, C. (2023). Add-On Treatment with Passiflora incarnata L., herba, during Benzodiazepine Tapering in Patients with Depression and Anxiety: A Real-World Study. Pharmaceuticals (Basel, Switzerland), 16(3), 426. https://doi.org/10.3390/ph16030426
Velasquez, A. C. A., Tsuji, M., Dos Santos Cordeiro, L., Petinati, M. F. P., Rebellato, N. L. B., Sebastiani, A. M., da Costa, D. J., & Scariot, R. (2024). Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial. Oral and maxillofacial surgery, 28(3), 1313–1320. https://doi.org/10.1007/s10006-024-01259-6
Carminati, M., Tondello, M., & Zanardi, R. (2024). Passiflora incarnata L., herba, in benzodiazepine tapering: long-term safety and efficacy in a real-world setting. Frontiers in psychiatry, 15, 1471083. https://doi.org/10.3389/fpsyt.2024.1471083
Wang, W., Zhai, G. Q., Xin, M., Li, J., Liao, J. J., Liang, J., & Li, C. B. (2024). Integrated network pharmacology and transcriptomics to reveal the mechanism of Passiflora against depressive disorder: An observational study. Medicine, 103(41), e39309. https://doi.org/10.1097/MD.0000000000039309
Zampieri, V. C., Gonçalves, I. L., Lira, A. L., Zeni, J., Backes, G. T., & Hsu, A. K. W. (2024). Exploring the Effects of a Calming Herbal Tea Blend on Perioperative Anxiety: A Randomized Clinical Trial. Journal of Medicinal Food. Advance online publication. https://doi.org/10.1089/jmf.2024.0170
Kim, G. H., Lim, K., Yang, H. S., Lee, J. K., Kim, Y., Park, S. K., Kim, S. H., Park, S., Kim, T. H., Moon, J. S., Hwang, I. K., Yoon, Y. S., Seo, H. S., Nam, S. M., Kim, M. Y., Yoon, S. G., Seong, J. K., & Yi, S. S. (2019). Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models. Journal of Chemical Neuroanatomy, 98, 27–40. https://doi.org/10.1016/j.jchemneu.2019.03.005
Kim, G. H., Kim, Y., Yoon, S., Kim, S. J., & Yi, S. S. (2019). Sleep-inducing effect of Passiflora incarnata L. extract by single and repeated oral administration in rodent animals. Food Science & Nutrition, 8(1), 557–566. https://doi.org/10.1002/fsn3.1341
Canella, C., Bachmann, C., Wolfensberger, B., & Witt, C. M. (2019). Patients' experiences attributed to the use of Passiflora incarnata: A qualitative, phenomenological study. Journal of ethnopharmacology, 231, 295–301. https://doi.org/10.1016/j.jep.2018.11.022
Sarris J. (2018). Herbal medicines in the treatment of psychiatric disorders: 10-year updated review. Phytotherapy research : PTR, 32(7), 1147–1162. https://doi.org/10.1002/ptr.6055
Ozturk, Z., & Kalayci, C. C. (2018). Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complementary therapies in medicine, 36, 30–32. https://doi.org/10.1016/j.ctim.2017.11.008
Rokhtabnak, F., Ghodraty, M. R., Kholdebarin, A., Khatibi, A., Seyed Alizadeh, S. S., Koleini, Z. S., Zamani, M. M., & Pournajafian, A. (2016). Comparing the Effect of Preoperative Administration of Melatonin and Passiflora incarnata on Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery. Anesthesiology and pain medicine, 7(1), e41238. https://doi.org/10.5812/aapm.41238
Schunck, R. V. A., Macedo, I. C., Laste, G., de Souza, A., Valle, M. T. C., Salomón, J. L. O., Nunes, E. A., Campos, A. C. W., Gnoatto, S. C. B., Bergold, A. M., Konrath, E. L., Dallegrave, E., Arbo, M. D., Torres, I. L. S., & Leal, M. B. (2017). Standardized Passiflora incarnata L. extract reverts the analgesia induced by alcohol withdrawal in rats. Phytotherapy Research, 31(8), 1199–1208. https://doi.org/10.1002/ptr.5839
Dantas, L. P., de Oliveira-Ribeiro, A., de Almeida-Souza, L. M., & Groppo, F. C. (2017). Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Medicina oral, patologia oral y cirugia bucal, 22(1), e95–e101. https://doi.org/10.4317/medoral.21140
Aman, U., Subhan, F., Shahid, M., Akbar, S., Ahmad, N., Ali, G., Fawad, K., & Sewell, R. D. (2016). Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms. BMC complementary and alternative medicine, 16, 77. https://doi.org/10.1186/s12906-016-1048-6
Jawna-Zboińska, K., Blecharz-Klin, K., Joniec-Maciejak, I., Wawer, A., Pyrzanowska, J., Piechal, A., Mirowska-Guzel, D., & Widy-Tyszkiewicz, E. (2016). Passiflora incarnata L. Improves Spatial Memory, Reduces Stress, and Affects Neurotransmission in Rats. Phytotherapy research : PTR, 30(5), 781–789. https://doi.org/10.1002/ptr.5578
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Copyright (c) 2024 Izabela Kaźmierczyk, Mateusz Bychowski, Julia Kwaśna, Adrianna Załęska, Kacper Lenart, Mateusz Górski, Michał Homza, Natalia Zakrzewska, Szymon Bednarek, Joanna Kulicka
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