Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Quality in Sport

Unlocking the Power of Cinnamon: A Detailed Review of Cinnamon Therapeutic Effects in Chronic Disease Management
  • Home
  • /
  • Unlocking the Power of Cinnamon: A Detailed Review of Cinnamon Therapeutic Effects in Chronic Disease Management
  1. Home /
  2. Archives /
  3. Vol. 28 (2024) /
  4. Medical Sciences

Unlocking the Power of Cinnamon

A Detailed Review of Cinnamon Therapeutic Effects in Chronic Disease Management

Authors

  • Joanna Kulicka Medical University of Lodz, Poland https://orcid.org/0009-0009-1614-482X
  • Mateusz Bychowski Medical University of Lodz, Poland https://orcid.org/0009-0004-9034-2756
  • Julia Kwaśna Medical University of Gdansk, Poland https://orcid.org/0009-0006-2314-2329
  • Adrianna Załęska Medical University of Lodz, Poland https://orcid.org/0009-0004-6772-3956
  • Izabela Kaźmierczyk Medical University of Lodz, Poland https://orcid.org/0009-0006-7798-7765
  • Kacper Lenart Medical University of Lodz, Poland https://orcid.org/0009-0003-5092-8835
  • Mateusz Górski Medical University of Lodz, Poland https://orcid.org/0009-0003-3473-132X
  • Michał Homza Medical University of Lodz, Poland https://orcid.org/0009-0002-4651-5520
  • Natalia Zakrzewska Medical University of Lodz, Poland https://orcid.org/0009-0003-0405-2764
  • Szymon Bednarek Medical University of Lodz, Poland https://orcid.org/0009-0001-3189-8322

DOI:

https://doi.org/10.12775/QS.2024.28.56834

Keywords

Cinnamon, Cinnamaldehyde, Antioxidants, Anti-inflammatory, Neuroprotection, Skin health, Type 2 diabetes, Cardiovascular disease, Reproductive health, PCOS

Abstract

Cinnamon, a widely used spice, has gained attention for its therapeutic properties, including antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. This review synthesizes current evidence on cinnamon's potential health benefits, particularly in managing metabolic, cardiovascular, dermatological, neurological, and reproductive health conditions. A systematic search of databases like PubMed, Google Scholar, and Scopus was conducted using keywords such as "cinnamon," "cinnamaldehyde," "antioxidants," and "type 2 diabetes." A total of 32 studies were selected, covering preclinical studies, clinical trials, and reviews.

The review focuses on bioactive compounds in cinnamon, such as cinnamaldehyde, cinnamic acid, and polyphenols, which help reduce oxidative stress, modulate immune responses, and improve metabolic parameters. Cinnamon also shows promise in promoting skin health, enhancing wound healing, and supporting reproductive health, especially in conditions like PCOS. However, most studies are based on animal models or in vitro experiments, with limited human clinical trials. More rigorous clinical research is needed to confirm cinnamon’s efficacy, safety, and appropriate dosages for long-term use.

In conclusion, while preclinical data is promising, further human studies are crucial to fully establish cinnamon’s therapeutic potential.

References

Aioub AAA, Abdelnour SA, Hashem AS, et al. Cinnamon nanoemulsion mitigates acetamiprid-induced hepatic and renal toxicity in rats: biochemical, histopathological, immunohistochemical, and molecular docking analysis. BMC Vet Res. 2024;20(1):256. Published 2024 Jun 12. doi:10.1186/s12917-024-04084-x

Arif M, Alam M, Malhi SM, et al. In vivo evaluation of medicinal effects of Myristica fragrans, Cinnamomum zeylanicum, Mucuna pruriens on male murine fertility. Pak J Pharm Sci. 2024;37(3):601-611.

Arisha SM, Sakr SA, Abd-Elhaseeb FR. Cinnamomum zeylanicum alleviate testicular damage induced by high fat diet in albino rats; histological and ultrastructural studies [retracted in: Heliyon. 2023 Jun 07;9(6):e17025. doi: 10.1016/j.heliyon.2023.e17025]. Heliyon. 2020;6(11):e05584. Published 2020 Nov 23. doi:10.1016/j.heliyon.2020.e05584

Chakrabarti S, Jana M, Roy A, Pahan K. Upregulation of Suppressor of Cytokine Signaling 3 in Microglia by Cinnamic Acid. Curr Alzheimer Res. 2018;15(10):894-904. doi:10.2174/1567205015666180507104755

Choockong C, Itharat A, Pipatrattanaseree W, et al. The most commonly used spices in Thai traditional medicine: in vitro evaluation of anti-hyperglycemic, antioxidant, polyphenol content, and nitric oxide production inhibitory activities. Res Pharm Sci. 2024;19(1):13-28. Published 2024 Feb 6. doi:10.4103/1735-5362.394817

Cansız D, Özokan G, Bilginer A, et al. Effects of benzoic acid synthesized from Cinnamomum cassia by green chemistry on valproic acid-induced neurotoxicity in zebrafish embryos. Toxicol Mech Methods. 2024;34(7):833-843. doi:10.1080/15376516.2024.2364899

Cochran L, Nadolny R, Garcia K, et al. Available Treatments and Adjunctive Therapies for Polycystic Ovarian Syndrome (PCOS) Patients of Reproductive Age: A Scoping Review. Cureus. 2024;16(9):e70501. Published 2024 Sep 30. doi:10.7759/cureus.70501

Jaramillo Jimenez BA, Awwad F, Desgagné-Penix I. Cinnamaldehyde in Focus: Antimicrobial Properties, Biosynthetic Pathway, and Industrial Applications. Antibiotics (Basel). 2024;13(11):1095. Published 2024 Nov 18. doi:10.3390/antibiotics13111095

Isik B, Suleyman B, Mammadov R, et al. Protective effect of cinnamon extract against cobalt-induced multiple organ damage in rats. Front Pharmacol. 2024;15:1384181. Published 2024 May 9. doi:10.3389/fphar.2024.1384181

Khurshid S, Farwa U, Mazhar Z, Naeem H, Ishaq Y. Evaluation of Aloe Vera Gel Combined with Cinnamon Oil with Antibacterial Activity for Wound Healing Application. Int J Low Extrem Wounds. Published online June 4, 2024. doi:10.1177/15347346241259102

Kumar S, Kumari R, Mishra S. Pharmacological properties and their medicinal uses of Cinnamomum: a review. J Pharm Pharmacol. 2019;71(12):1735-1761. doi:10.1111/jphp.13173

Maalouly G, Martin CM, Baz Y, Saliba Y, Baramili AM, Fares N. Antioxidant and Anti-Apoptotic Neuroprotective Effects of Cinnamon in Imiquimod-Induced Lupus. Antioxidants (Basel). 2024;13(7):880. Published 2024 Jul 22. doi:10.3390/antiox13070880

Miranda CS, Marinho E, Seabra CL, et al. Antimicrobial, antioxidant and cytocompatible coaxial wet-spun fibers made of polycaprolactone and cellulose acetate loaded with essential oils for wound care. Int J Biol Macromol. 2024;277(Pt 4):134565. doi:10.1016/j.ijbiomac.2024.134565

Mohammadabadi T, Jain R. Cinnamon: a nutraceutical supplement for the cardiovascular system. Arch Med Sci Atheroscler Dis. 2024;9:e72-e81. Published 2024 Mar 30. doi:10.5114/amsad/184245

Monteiro ÁB, Nunes de Andrade HH, da Cruz Guedes E, et al. Neuroprotective effect of cinnamic alcohol: A bioactive compound of Cinnamomum spp. essential oil. Neurochem Int. 2024;179:105807. doi:10.1016/j.neuint.2024.105807

Peng J, Song X, Yu W, et al. The role and mechanism of cinnamaldehyde in cancer. J Food Drug Anal. 2024;32(2):140-154. doi:10.38212/2224-6614.3502

Patel SK, Vikram A, Pathania D, et al. Allergic potential & molecular mechanism of skin sensitization of cinnamaldehyde under environmental UVB exposure. Chemosphere. Published online October 8, 2024. doi:10.1016/j.chemosphere.2024.143508

Pirami H, Khavanin A, Nadri F, Tajpoor A, Mehrifar Y, Tirani ZM. The combined effects of noise and vibration stress on sex hormone levels, fertility capacity, and the protective role of cinnamon extract in rats: an experimental study. Arch Environ Occup Health. 2022;77(9):764-773. doi:10.1080/19338244.2021.2011085

Qarani W, Husna F, Yulia W, et al. Antioxidant and antiaging activities of Cinnamomum burmannii, Michelia champaca and their combinations. Narra J. 2023;3(2):e111. doi:10.52225/narra.v3i2.111

Ranasinghe P, Pigera S, Premakumara GA, Galappaththy P, Constantine GR, Katulanda P. Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complement Altern Med. 2013;13:275. Published 2013 Oct 22. doi:10.1186/1472-6882-13-275

Ranasinghe P, Jayawardena R, Pigera S, et al. Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. BMC Complement Altern Med. 2017;17(1):550. Published 2017 Dec 28. doi:10.1186/s12906-017-2067-7

Rezaei Z, Momtaz S, Gharazi P, et al. Cinnamic Acid Ameliorates Acetic Acid-induced Inflammatory Response through Inhibition of TLR-4 in Colitis Rat Model. Antiinflamm Antiallergy Agents Med Chem. 2024;23(1):21-30. doi:10.2174/0118715230278980231212103709

Riós Pérez MF, Quintero Lira A, Piloni Martini J, et al. Physicochemical Characterization of Yogurt Fortified with Microencapsulated Cinnamon (Cinnamomum zeylanicum) and Its Effects on Metabolic Syndrome Induced in Rabbits (Oryctolagus cuniculus). J Med Food. 2024;27(8):758-774. doi:10.1089/jmf.2023.0153

Salari M, Nakhaee S, Ataie Z, Farrokhfall K. The effects of advanced age on electrocardiographic parameters, lipid profile and redox balance in male rats: role of long-term cinnamon consumption. Iran J Vet Res. 2024;25(2):107-116. doi:10.22099/IJVR.2024.47879.6948

Shu C, Ge L, Li Z, et al. Antibacterial activity of cinnamon essential oil and its main component of cinnamaldehyde and the underlying mechanism. Front Pharmacol. 2024;15:1378434. Published 2024 Mar 11. doi:10.3389/fphar.2024.1378434

Su YS, Cheng MJ, Kwan AL, et al. The crude extract obtained from Cinnamomum macrostemon Hayata regulates oxidative stress and mitophagy in keratinocytes. Biosci Biotechnol Biochem. 2024;88(5):529-537. doi:10.1093/bbb/zbae022

Wang YC, Wang V, Chen BH. Analysis of bioactive compounds in cinnamon leaves and preparation of nanoemulsion and byproducts for improving Parkinson's disease in rats. Front Nutr. 2023;10:1229192. Published 2023 Aug 2. doi:10.3389/fnut.2023.1229192

Xiaomei Z, Xiaoyan F. Effect of cinnamon as a Chinese herbal medicine on markers of cardiovascular risk in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. Eur J Obstet Gynecol Reprod Biol. 2024;300:253-261. doi:10.1016/j.ejogrb.2024.07.032

Yusha'u Y, Aminu Hanafi A, Muhammad Adam U. Antidepressant-Like Effects of Cinnamomum verum on Open-Space Forced Swim-Induced Depression in Mice. Niger J Physiol Sci. 2023;38(2):223-227. Published 2023 Dec 31. doi:10.54548/njps.v38i2.11

Zhang K, Ji J, Li N, Yin Z, Fan G. Integrated Metabolomics and Gut Microbiome Analysis Reveals the Efficacy of a Phytochemical Constituent in the Management of Ulcerative Colitis. Mol Nutr Food Res. 2024;68(3):e2200578. doi:10.1002/mnfr.202200578

Zarezadeh M, Musazadeh V, Foroumandi E, Keramati M, Ostadrahimi A, Mekary RA. The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes or with polycystic ovary syndrome: an umbrella meta-analysis on interventional meta-analyses. Diabetol Metab Syndr. 2023;15(1):127. Published 2023 Jun 15. doi:10.1186/s13098-023-01057-2

Zhang L, Lin S, Wang Y, et al. Cinnamon and its bioactive compounds in preventing obesity and metabolic disorders. Metabolomics. 2024;17(1):38. doi:10.1007/s11306-023-01647-6

Downloads

  • PDF

Published

2024-12-27

How to Cite

1.
KULICKA, Joanna, BYCHOWSKI, Mateusz, KWAŚNA, Julia, ZAŁĘSKA, Adrianna, KAŹMIERCZYK, Izabela, LENART, Kacper, GÓRSKI, Mateusz, HOMZA, Michał, ZAKRZEWSKA, Natalia and BEDNAREK, Szymon. Unlocking the Power of Cinnamon: A Detailed Review of Cinnamon Therapeutic Effects in Chronic Disease Management. Quality in Sport. Online. 27 December 2024. Vol. 28, p. 56834. [Accessed 28 June 2025]. DOI 10.12775/QS.2024.28.56834.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 28 (2024)

Section

Medical Sciences

License

Copyright (c) 2024 Joanna Kulicka, Mateusz Bychowski, Julia Kwaśna, Adrianna Załęska, Izabela Kaźmierczyk, Kacper Lenart, Mateusz Górski, Michał Homza, Natalia Zakrzewska, Szymon Bednarek

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Stats

Number of views and downloads: 327
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

Cinnamon, Cinnamaldehyde, Antioxidants, Anti-inflammatory, Neuroprotection, Skin health, Type 2 diabetes, Cardiovascular disease, Reproductive health, PCOS
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop