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Quality in Sport

The Role of Vitamin D in Acne Vulgaris: A Comprehensive Review of Recent Advances
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  • The Role of Vitamin D in Acne Vulgaris: A Comprehensive Review of Recent Advances
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The Role of Vitamin D in Acne Vulgaris: A Comprehensive Review of Recent Advances

Authors

  • Julia Kwaśna Medical University of Gdańsk https://orcid.org/0009-0006-2314-2329
  • Mateusz Bychowski Medical University of Łódź https://orcid.org/0009-0004-9034-2756
  • Mateusz Górski Medical University of Łódź https://orcid.org/0009-0003-3473-132X
  • Adrianna Załęska Medical University of Łódź https://orcid.org/0009-0004-6772-3956
  • Izabela Kaźmierczyk Medical University of Łódź https://orcid.org/0009-0006-7798-7765
  • Kacper Lenart Medical University of Łódź https://orcid.org/0009-0003-5092-8835
  • Michał Homza Medical University of Łódź https://orcid.org/0009-0002-4651-5520
  • Natalia Zakrzewska Medical University of Łódź https://orcid.org/0009-0003-0405-2764
  • Szymon Bednarek Medical University of Łódź https://orcid.org/0009-0001-3189-8322
  • Joanna Kulicka Medical University of Łódź https://orcid.org/0009-0009-1614-482X

DOI:

https://doi.org/10.12775/QS.2024.35.56315

Keywords

acne vulgaris, vitamin D deficiency, IL-1β, acne severity

Abstract

Acne vulgaris is a common dermatological condition affecting millions worldwide, particularly adolescents and young adults. Recent research suggests a potential link between vitamin D levels and acne severity, highlighting the role of vitamin D in immune regulation and inflammation. This review analyzes studies published from 2020 onward, focusing on the relationship between vitamin D deficiency and acne, as well as the therapeutic potential of vitamin D supplementation.


A systematic search on PubMed identified 10 significant studies, including 7 original research articles and 3 systematic reviews or meta-analyses. The findings indicate a notable prevalence of vitamin D deficiency among acne patients, with several studies showing significantly lower serum 25-hydroxyvitamin D levels compared to healthy controls. Furthermore, clinical trials demonstrated that topical vitamin D can effectively reduce inflammatory markers, suggesting its therapeutic potential.


Despite these findings, the relationship between vitamin D levels and acne severity is complex, with some studies showing no significant correlation. This inconsistency underscores the need for further investigation into the mechanisms linking vitamin D deficiency to acne. Overall, this review emphasizes the potential of vitamin D as a therapeutic target in acne management and calls for more robust studies to clarify its role in mitigating acne-related inflammation and improving patient outcomes.

References

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Alhetheli, G., Elneam, A. I. A., Alsenaid, A., & Al-Dhubaibi, M. (2020). Vitamin D Levels in Patients with and without Acne and Its Relation to Acne Severity: A Case-Control Study. Clinical, cosmetic and investigational dermatology, 13, 759–765. https://doi.org/10.2147/CCID.S271500

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Published

2024-12-16

How to Cite

1.
KWAŚNA, Julia, BYCHOWSKI, Mateusz, GÓRSKI, Mateusz, ZAŁĘSKA, Adrianna, KAŹMIERCZYK, Izabela, LENART, Kacper, HOMZA, Michał, ZAKRZEWSKA, Natalia, BEDNAREK, Szymon and KULICKA, Joanna. The Role of Vitamin D in Acne Vulgaris: A Comprehensive Review of Recent Advances. Quality in Sport. Online. 16 December 2024. Vol. 35, p. 56315. [Accessed 19 June 2025]. DOI 10.12775/QS.2024.35.56315.
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Vol. 35 (2024)

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Medical Sciences

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Copyright (c) 2024 Julia Kwaśna, Mateusz Bychowski, Mateusz Górski, Adrianna Załęska, Izabela Kaźmierczyk, Kacper Lenart, Michał Homza, Natalia Zakrzewska, Szymon Bednarek, Joanna Kulicka

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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