The Impact of Fasting and Dietary Interventions on the Development and Treatment of Non-Hodgkin’s Lymphomas and Other Cancers - a review
DOI:
https://doi.org/10.12775/QS.2024.17.52875Keywords
diet, fasting, cancer, lymphomas, non-Hodgkin’s lymphomaAbstract
Introduction: The present study investigated the role of fasting and diet in the development and treatment of cancers, with a focus on non-Hodgkin’s lymphomas. Dietary components and regimens have an impact on the risk of development of malignances as well as on the treatment of the disease. Cancerous subtypes react differently to various dietary compounds and regimes. Although not widely used- fasting can be valuable help in cancer treatment. In this article we show how diet modifications and restrictions can affect existing therapies.
Aim of the study: By analyzing current literature, the study aimed to understand how various dietary components and regimens influence cancer risk and treatment efficacy.
Methods: Extensive research was conducted using PubMed and Google Scholar. References from selected articles were included in the analysis.
Results: Consuming high amount of fruits and vegetables, unsaturated fats and supplementing vitamin D can reduce the risk of malignancies, with red meat, dairy products and saturated fats intake increasing it. Fasting affects lipid, glucose, protein and neuroendocrine metabolism in the way that helps the treatment of cancers. It slows down tumor growth, reduces some symptoms and improves the effects of chemotherapy. Exploring this topic further could propagate suitable diets for cancer subtypes as well as popularize fasting, which is not yet a widely known adition to standard anti-cancer treatments.
References
Arafat, H. M., Omar, J., Shafii, N., Naser, I. A., Al Laham, N. A., Muhamad, R., Al-Astani, T. A. D., Shaqaliah, A. J., Shamallakh, O. M., Shamallakh, K. M., & Abusalah, M. A. H. (2023). The association between breast cancer and consumption of dairy products: A systematic review. Annals of Medicine, 55(1), 2198256. https://doi.org/10.1080/07853890.2023.2198256
Aschebrook-Kilfoy, B., Ollberding, N. J., Kolar, C., Lawson, T. A., Smith, S. M., Weisenburger, D. D., & Chiu, B. C.-H. (2012). Meat intake and risk of non-Hodgkin lymphoma. Cancer Causes & Control: CCC, 23(10), 1681–1692. https://doi.org/10.1007/s10552-012-0047-2
Bauersfeld, S. P., Kessler, C. S., Wischnewsky, M., Jaensch, A., Steckhan, N., Stange, R., Kunz, B., Brückner, B., Sehouli, J., & Michalsen, A. (2018). The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: A randomized cross-over pilot study. BMC Cancer, 18(1), 476. https://doi.org/10.1186/s12885-018-4353-2
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003). Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. The New England Journal of Medicine, 348(17), 1625–1638. https://doi.org/10.1056/NEJMoa021423
Cancemi, G., Cicero, N., Allegra, A., & Gangemi, S. (2023). Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders. Antioxidants (Basel, Switzerland), 12(9), 1674. https://doi.org/10.3390/antiox12091674
Chan, L. N., & Müschen, M. (2017). B-cell identity as a metabolic barrier against malignant transformation. Experimental Hematology, 53, 1–6. https://doi.org/10.1016/j.exphem.2017.06.004
de Cabo, R., & Mattson, M. P. (2019). Effects of Intermittent Fasting on Health, Aging, and Disease. The New England Journal of Medicine, 381(26), 2541–2551. https://doi.org/10.1056/NEJMra1905136
de Groot, S., Lugtenberg, R. T., Cohen, D., Welters, M. J. P., Ehsan, I., Vreeswijk, M. P. G., Smit, V. T. H. B. M., de Graaf, H., Heijns, J. B., Portielje, J. E. A., van de Wouw, A. J., Imholz, A. L. T., Kessels, L. W., Vrijaldenhoven, S., Baars, A., Kranenbarg, E. M.-K., Carpentier, M. D., Putter, H., van der Hoeven, J. J. M., … Dutch Breast Cancer Research Group (BOOG). (2020). Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nature Communications, 11(1), 3083. https://doi.org/10.1038/s41467-020-16138-3
Di Francesco, A., Di Germanio, C., Bernier, M., & de Cabo, R. (2018). A time to fast. Science (New York, N.Y.), 362(6416), 770–775. https://doi.org/10.1126/science.aau2095
Fallahzadeh, H., Cheraghi, M., Amoori, N., & Alaf, M. (2014). Red meat intake and risk of non-Hodgkin lymphoma: A meta-analysis. Asian Pacific Journal of Cancer Prevention: APJCP, 15(23), 10421–10425. https://doi.org/10.7314/apjcp.2014.15.23.10421
Goldhamer, A. C., Klaper, M., Foorohar, A., & Myers, T. R. (2015). Water-only fasting and an exclusively plant foods diet in the management of stage IIIa, low-grade follicular lymphoma. BMJ Case Reports, 2015, bcr2015211582. https://doi.org/10.1136/bcr-2015-211582
Hurtado-Barroso, S., Trius-Soler, M., Lamuela-Raventós, R. M., & Zamora-Ros, R. (2020). Vegetable and Fruit Consumption and Prognosis Among Cancer Survivors: A Systematic Review and Meta-Analysis of Cohort Studies. Advances in Nutrition (Bethesda, Md.), 11(6), 1569–1582. https://doi.org/10.1093/advances/nmaa082
Kim, Y. H., Lee, J. H., Yeung, J. L.-H., Das, E., Kim, R. Y., Jiang, Y., Moon, J. H., Jeong, H., Thakkar, N., Son, J. E., Trzaskalski, N., Hui, C.-C., Doh, K.-O., Mulvihill, E. E., Kim, J.-R., Kim, K.-H., & Sung, H.-K. (2019). Thermogenesis-independent metabolic benefits conferred by isocaloric intermittent fasting in ob/ob mice. Scientific Reports, 9(1), 2479. https://doi.org/10.1038/s41598-019-39380-2
La Vecchia, C., & Tavani, A. (1998). Fruit and vegetables, and human cancer. European Journal of Cancer Prevention: The Official Journal of the European Cancer Prevention Organisation (ECP), 7(1), 3–8.
Michalsen, A. (2010). Prolonged fasting as a method of mood enhancement in chronic pain syndromes: A review of clinical evidence and mechanisms. Current Pain and Headache Reports, 14(2), 80–87. https://doi.org/10.1007/s11916-010-0104-z
Myers, T. R., Zittel, M., & Goldhamer, A. C. (2018). Follow-up of water-only fasting and an exclusively plant food diet in the management of stage IIIa, low-grade follicular lymphoma. BMJ Case Reports, 2018, bcr2018225520, bcr-2018–225520. https://doi.org/10.1136/bcr-2018-225520
Potre, C., Borsi, E., Potre, O., Ionita, I., Samfireag, M., Costachescu, D., Secosan, C., Lazar, S., & Ristescu, A. I. (2023). A Systematic Review Assessing the Impact of Vitamin D Levels on Adult Patients with Lymphoid Malignancies. Current Oncology (Toronto, Ont.), 30(4), 4351–4364. https://doi.org/10.3390/curroncol30040331
Puchalska, P., & Crawford, P. A. (2017). Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics. Cell Metabolism, 25(2), 262–284. https://doi.org/10.1016/j.cmet.2016.12.022
Raucci, F., Vernieri, C., Di Tano, M., Ligorio, F., Blaževitš, O., Lazzeri, S., Shmahala, A., Fragale, G., Salvadori, G., Varano, G., Casola, S., Buono, R., Visco, E., de Braud, F., & Longo, V. D. (2024). Cyclic Fasting-Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia. Cancer Research, 84(7), 1133–1148. https://doi.org/10.1158/0008-5472.CAN-23-0295
Rohrmann, S., Linseisen, J., Jakobsen, M. U., Overvad, K., Raaschou-Nielsen, O., Tjonneland, A., Boutron-Ruault, M. C., Kaaks, R., Becker, N., Bergmann, M., Boeing, H., Khaw, K.-T., Wareham, N. J., Key, T. J., Travis, R., Benetou, V., Naska, A., Trichopoulou, A., Pala, V., … Vineis, P. (2011). Consumption of meat and dairy and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 128(3), 623–634. https://doi.org/10.1002/ijc.25387
Safdie, F. M., Dorff, T., Quinn, D., Fontana, L., Wei, M., Lee, C., Cohen, P., & Longo, V. D. (2009). Fasting and cancer treatment in humans: A case series report. Aging, 1(12), 988–1007. https://doi.org/10.18632/aging.100114
Schreck, K. C., Hsu, F.-C., Berrington, A., Henry-Barron, B., Vizthum, D., Blair, L., Kossoff, E. H., Easter, L., Whitlow, C. T., Barker, P. B., Cervenka, M. C., Blakeley, J. O., & Strowd, R. E. (2021). Feasibility and Biological Activity of a Ketogenic/Intermittent-Fasting Diet in Patients With Glioma. Neurology, 97(9), e953–e963. https://doi.org/10.1212/WNL.0000000000012386
Skibola, C. F. (2007). Obesity, diet and risk of non-Hodgkin lymphoma. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 16(3), 392–395. https://doi.org/10.1158/1055-9965.EPI-06-1081
Skuladottir, H., Tjoenneland, A., Overvad, K., Stripp, C., & Olsen, J. H. (2006). Does high intake of fruit and vegetables improve lung cancer survival? Lung Cancer (Amsterdam, Netherlands), 51(3), 267–273. https://doi.org/10.1016/j.lungcan.2005.06.009
Slavin, J. L., & Lloyd, B. (2012). Health benefits of fruits and vegetables. Advances in Nutrition (Bethesda, Md.), 3(4), 506–516. https://doi.org/10.3945/an.112.002154
Sutton, E. F., Beyl, R., Early, K. S., Cefalu, W. T., Ravussin, E., & Peterson, C. M. (2018). Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metabolism, 27(6), 1212-1221.e3. https://doi.org/10.1016/j.cmet.2018.04.010
Tang, C.-C., Huang, T.-C., Tien, F.-M., Lin, J.-M., Yeh, Y.-C., & Lee, C.-Y. (2021). Safety, Feasibility, and Effects of Short-Term Calorie Reduction during Induction Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Pilot Study. Nutrients, 13(9), 3268. https://doi.org/10.3390/nu13093268
Thompson, H. J., & McTiernan, A. (2011). Weight cycling and cancer: Weighing the evidence of intermittent caloric restriction and cancer risk. Cancer Prevention Research (Philadelphia, Pa.), 4(11), 1736–1742. https://doi.org/10.1158/1940-6207.CAPR-11-0133
Tinsley, G. M., & La Bounty, P. M. (2015). Effects of intermittent fasting on body composition and clinical health markers in humans. Nutrition Reviews, 73(10), 661–674. https://doi.org/10.1093/nutrit/nuv041
Urena-Torres, P., & Souberbielle, J. (2014). Pharmacologic Role of Vitamin D Natural Products. Current Vascular Pharmacology, 12(2), 278–285. https://doi.org/10.2174/15701611113119990020
Varady, K. A., Bhutani, S., Klempel, M. C., Kroeger, C. M., Trepanowski, J. F., Haus, J. M., Hoddy, K. K., & Calvo, Y. (2013). Alternate day fasting for weight loss in normal weight and overweight subjects: A randomized controlled trial. Nutrition Journal, 12(1), 146. https://doi.org/10.1186/1475-2891-12-146
Wang, J., Li, X., & Zhang, D. (2016). Dairy Product Consumption and Risk of Non-Hodgkin Lymphoma: A Meta-Analysis. Nutrients, 8(3), 120. https://doi.org/10.3390/nu8030120
Yoshii, R., Higashida, K., & Nakai, N. (2023). Intermittent fasting reduces mouse body fat while maintaining muscle mass by regulating protein synthesis and autophagy. Nutrition (Burbank, Los Angeles County, Calif.), 115, 112130. https://doi.org/10.1016/j.nut.2023.112130
Zubrzycki, A., Cierpka-Kmiec, K., Kmiec, Z., & Wronska, A. (2018). The role of low-calorie diets and intermittent fasting in the treatment of obesity and type-2 diabetes. Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society, 69(5). https://doi.org/10.26402/jpp.2018.5.02
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Krzysztof Bilecki, Paulina Cuper, Ilona Jastrzębska, Michał Andrzej Kozicz, Hubert Gugulski, Michał Bado, Patrycja Nowoświat, Michał Goncerz
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 163
Number of citations: 0
