Features of circulating in the blood desquamated endotheliocytes at the patients with ischemic heart disease and combined with hypertonic disease

Abstract

Introduction and aim. In the process of implementing the project “Nosologically determined features of the state of desquamated circulating endothelial cells and the lipid spectrum of plasma”, we first conducted a comparative study of 38 patients of both sexes with stage II hypertension (AH II), which in 20 of them was accompanied by chronic alcoholism as well as 21 healthy volunteers. It was found that alcoholism is accompanied by minimal for the sample subnormal levels of markedly and terminally altered circulating endothelial cells (ACEC), LDLP cholesterol, triglycerides, prothrombin, Klimov’s and Dobiásová’s&Frolich’s atherogenity indices, ankle-brachial index of blood pressure (as atherogenity marker) as well as glucose, platelets and leukocytes. Instead, such patients have the maximum for the sample levels of HDLP cholesterol, erythrocytes sedimentation rate, body mass index, urea and creatinine. At the same time, the levels of hemoglobin, erythrocytes and cholesterol total as well as negentropy of endotheliocytogram and lipidogram did not differ from the controls, despite the presence of AH II. Both diastolic and systolic hypertension was less pronounced than in sober patients. The aim of this study was to determine the characteristics of CECs and plasma lipid spectrum in patients with Ischemic Heart Disease (IHD) and comorbidity IHD&AH II.

Material and methods. The object of clinical observation was 20 patients of both sexes with IHD and 44 with comorbidity IHD&AH II as well as 21 healthy volunteers. The battery of tests remained the same.

Results. In patients with comorbidity IHD&AH II the levels of ACEC in total and markedly ACEC in particular as well as systolic and diastolic BP significantly exceeded those in patients with IHD. The difference between the levels of terminally ACEC was less pronounced, but statistically significant. In contrast, patients with IHD had significantly higher levels of initially ACEC, metabolic syndrome index, total cholesterol and, especially, Klimov’s atherogenity index. There were no differences between the groups regarding moderately increased levels of LDLP cholesterol, glucose and prothrombin as well as moderately decreased levels of urea and ankle-brachial index. However, in patients with IHD, a drastic increase in triglyceride levels and Dobiásová’s&Frolich’s atherogenity index and, to a lesser extent, body mass index was found in combination with a decrease in HDLP cholesterol and negentropy of lipidogram, while in patients with comorbidity IHD&AH II, the listed variables did not differ from the controls.

Conclusion. In the observed cohort of patients, ischemic heart disease was accompanied by a significant increase in the level of desquamated circulating endothelial cells with varying degrees of changes, especially markedly altered, and plasma atherogenicity, as well as, to a lesser extent, glycemia and prothrombin. The burden of IHD by hypertension had an ambiguous effect on the listed variables.