Relationships between changes in entropy of the EEG and parameters of the immunity
KeywordsEEG, HRV, Immunity, Entropy, Relationships, Balneotherapy.
AbstractBackground. Previously, we have shown that the entropy of the normalized parameters of the HRV and spectral power density (SPD) of loci of EEG significantly correlate with the entropy and parameters of immunity, which testifies to their modulating regulatory effects. The purpose of this study is to analyze the relationships between changes in entropy and immunity under the influence of natural adaptogens. Material and methods. In basal conditions in 37 men and 14 women with chronic pyelonephritis and cholecystitis in remission as well as without clinical diagnose but with dysfunction of neuro-endocrine-immune complex and metabolism, we recorded twice, before and after balneotherapy at the spa Truskavets’, EEG (“NeuroCom Standard”) and HRV (“Cardiolab+VSR”). Than we evaluated immune status on a set of I and II levels recommended by the WHO. The Entropy of normalized SPD for each locus of EEG and HRV as well as Immunocytogram and Leukocytogram calculated using Shannon’s formula. Results. Preliminary analysis revealed different orientation of entropy changes in patients, so three clusters were created. Balneotherapy has a generalized negentropic effect on EEG of 2/3 patients. On the other hand, the members of the other two clusters have substantially increased EEG entropy overall, but there are significant differences with respect to individual loci. The immunotropic effects of balneotherapy are unrelated to changes in integral entropy of EEG. As a result of discriminant analysis were selected as characteristic entropy changes at only 9 loci out of 16, accompanied by changes in 10 partial parameters of immunity and integral immune index, as well as Popovych’s Leukocytogram Strain Index-2. Conclusion. Balneotherapy causes multivariate entropy changes of individual EEG loci, conditioned by a number of predictors. This is accompanied by characteristic changes in certain parameters of immunity in line with the concept of immune homunculus.
Baevskiy RM, Ivanov GG. Heart Rate Variability: theoretical aspects and possibilities of clinical application [in Russian]. Ultrazvukovaya i funktsionalnaya diagnostika. 2001; 3: 106-127.
Barylyak LG., Malyuchkova RV, Tolstanov OB, Tymochko OB, Hryvnak RF, Uhryn MR. Comparative estimation of informativeness of leucocytary index of adaptation by Garkavi and by Popovych. Medical Hydrology and Rehabilitation. 2013; 11(1): 5-20.
Berntson GG, Bigger JT jr, Eckberg DL, Grossman P, Kaufman PG, Malik M, Nagaraja HN, Porges SW, Saul JP, Stone PH, Van der Molen MW. Heart Rate Variability: Origines, methods, and interpretive caveats. Psychophysiology. 1997; 34: 623-648.
Cahn BR, Polish J. Psychological bulletin meditation states and traits: EEG, ERP and neuroimaging studies. Psychol. Bull. 2006; 132: 180-211.
Chavan SS, Pavlov VA, Tracey KJ. Mechanism and therapeutic relevance of neuro-imune communication. Immunity. 2017; 46: 927-942.
Chavan SS, Tracey KJ. Essencial Neuroscience in Immunology. J Immunol. 2017; 198: 3389-3397.
Gozhenko AI, Popadynets’ OO, Zukow WA, Popovych IL. Differences in parameters of the EEG and HRV in the humans with various levels of the entropy of EEG, HRV, immunocytogram and leukocytogram. In: Collection of Proceedings of the Scientific and Practical Conference: Galician Readings "Contemporary ideas on the pathogenesis of inflammation: local and systemic mechanisms" (Ivano-Frankivs’k, 19-20 September). Ivano-Frankivs’k: IFNMU; 2019: 73-74.
Heart Rate Variability. Standards of Measurement, Physiological Interpretation, and Clinical Use. Task Force of ESC and NASPE. Circulation. 1996; 93(5): 1043-1065.
Ivassivka SV. Biological Active Substances of Water Naftussya, their Genesis and Mechanisms of Physiological Effects [in Ukrainian]. Kyiv: Naukova dumka. 1997. 110 p.
Ivassivka SV, Bilas VR, Popovych AI. Influence applications of ozokerite on phone of chronic stress on parameters of neuro-endocrine-immune complex and hydro-electrolyte exchange at rats. Communication 1: Stresslimiting,sanogene and neutral effects [in Ukrainian]. Medical Hydrology and Rehabilitation. 2008; 6(4): 65-72.
Ivassivka SV, Bilas VR, Popovych AI. Stresslimiting effects of ozokerite on neuro-endocrine-immune complex at rats. International Scientific Congress and 61-st Session of the General Assembly of the World Federation of Hydrotherapy Climatotherapy (FEMTEC). Congress materials (China, November 26-28, 2008). 216-217.
Ivassivka SV, Bubnyak AB, Kovbasnyuk ММ, Popovych IL. Genesis and role of phenols in waters from Naftussya layer [in Ukrainian]. In: Problems of pathology in experiment and clinic. Scientific works of Drohobych Medical Institute. Vol. XV. Drohobych. 1994. 6-11.
Іvassivka SV, Popovych IL, Aksentijchuk BI, Bilas VR. Nature of Balneofactors of Water Naftussya and Essence its Curative and Prophilactive Effects [in Ukrainian]. Truskavets’: Truskavets’kurort. 1999. 125 p.
Klecka WR. Discriminant Analysis [trans. from English in Russian] (Seventh Printing, 1986). In: Factor, Discriminant and Cluster Analysis. Moskva: Finansy i Statistika; 1989: 78-138.
Kostyuk PG, Popovych IL, Іvassivka SV (editors). Chornobyl’, Adaptive and Defensive Systems, Rehabilitation [in Ukrainian]. Kyiv: Computerpress. 2006. 348 p.
Matthews SC, Paulus MP, Simmons AN et al. Functional subdivision with anterior cingulate cortex and their relationship to autonomic nervous system function. Neuroimage. 2004; 22(3): 1151-1156.
Pavlov VA, Chavan SS, Tracey KJ. Molecular and functional neuroscience in immunity. Annu Rev Immunol. 2018; 36: 783-812.
Petsyukh SV, Petsyukh MS, Kovbasnyuk MM, Barylyak LG, Zukow W. Relationships between Popovych’s Adaptation Index and parameters of ongoiging HRV and EEG in patients with chronic pyelonephrite and cholecystite in remission. Journal of Education, Health and Sport. 2016; 6(2): 99-110.
Popadynets’ OO, Gozhenko AI, Zukow W, Popovych IL. Relationships between the entropies of EEG, HRV, immunocytogram and leukocytogram. Journal of Education, Health and Sport. 2019; 9(5): 651-666.
Popadynets’ OO, Gozhenko AI, Zukow W, Popovych IL. Interpersonal differences between of the entropies of EEG, HRV, immunocytogram and leukocytogram. Journal of Education, Health and Sport. 2019; 9(6): 534-545.
Popadynets’ OO, Gozhenko AI, Zukow W, Popovych IL. Peculiarities of spectral parameters of EEG, HRV and routine parameters of immunity in patients with various levels of the entropy of EEG, HRV, immunocytogram and leukocytogram. Journal of Education, Health and Sport. 2019; 9(8): 617-636.
Popadynets’ OO, Gozhenko AI, Badiuk NS, Zukow W, Popovych IL. Interpersonal differences between caused by adaptogens changes in the entropies of EEG, HRV, immunocytogram and leukocytogram. In: Rehabilitation Medicine and Health-Resort Institutions Development. Proceedings of the 19th International Applied Research Conference (Kyїv, 11-12 December 2019). Edited by O. Gozhenko, W. Zukow. Toruń, Kyiv. 2019: 51-53.
Popovych AI. Features of the immunotropic effects of partial components of the balneotherapeutic complex of spa Truskavets’. Journal of Education, Health and Sport. 2018; 8(12): 919-935.
Popovych AI. Features of the neurotropic effects of partial components of the balneotherapeutic complex of spa Truskavets’. Journal of Education, Health and Sport. 2019; 9(1): 396-409.
Popоvych IL. Information effects of bioactive water Naftyssya in rats: modulation entropic, prevention desynchronizing and limitation of disharmonizing actions water immersion stress for information components of neuro-endocrine-immune system and metabolism, which correlates with gastroprotective effect [in Ukrainian]. Medical Hydrology and Rehabilitation. 2007; 5(3): 50-70.
Popovych IL. Stresslimiting Adaptogene Mechanism of Biological and Curative Activity of Water Naftussya [in Ukrainian]. Kyiv. Computerpress; 2011: 300 p.
Popovych IL, Barylyak LG. Influence of course using of bioactive water Naftussya on stress level at women with endocrine and gynecological pathology [in Ukrainian]. Medical Hydrology and Rehabilitation. 2009; 7(3): 100-118.
Popovych IL, Flyunt IS, Alyeksyeyev OI, Barylyak LG, Bilas VR. Sanogenetic Bases of Rehabilitation on Spa Truskavets’ Urological Patients from Chornobylian Contingent [in Ukrainian]. Kyiv. Computerpress; 2003: 192 p.
Popovych IL, Kul’chyns’kyi AB, Gozhenko AI, Zukow W, Kovbasnyuk MM, Korolyshyn TA. Interrelations between changes in parameters of HRV, EEG and phagocytosis at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2018; 8(2): 135-156.
Popovych IL, Kul’chyns’kyi AB, Korolyshyn TA, Zukow W. Interrelations between changes in parameters of HRV, EEG and cellular immunity at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2017; 7(10): 11-23.
Popovych IL, Kozyavkina OV, Kozyavkina NV, Korolyshyn TA, Lukovych YuS, Barylyak LG. Correlation between Indices of the Heart Rate Variability and Parameters of Ongoing EEG in Patients Suffering from Chronic Renal Pathology. Neurophysiology. 2014; 46(2): 139-148.
Popovych IL, Lukovych YuS, Korolyshyn TA, Barylyak LG, Kovalska LB, Zukow W. Relationship between the parameters heart rate variability and background EEG activity in healthy men. Journal of Health Sciences. 2013; 3(4): 217-240.
Prinsloo GE, Rauch HG, Karpul D, Derman WE. The effect of a Single Session of Short Duration Heart Rate Variability Biofeedback on EEG: A Pilot Study. Appl. Psychophysiol. Biofeedback. 2013; 38(1): 45-56.
Romodanov AP (editor). Postradiation Encephalopathy. Experimental Researches and Clinical Observations [in Ukrainian and Russian]. Kyiv. USRI of Neurosurgery; 1993: 224 p.
Shannon CE. Works on the theory of informatics and cybernetics [transl. from English to Russian]. Moskwa: Inostrannaya literatura; 1963: 329 p.
Tang YY, Ma Y, Fan Y et al. Central and autonomic nervous system interaction is altered by short-term meditation. Proc. Natl. Acad. Sci. USA. 2009; 106(22): 8865-8870.
Thayer JF, Sternberg EM. Neural aspects of immunomodulation: Focus on the vagus nerve. Brain Behav Immun. 2010; 24(8): 1223-1228.
Tracey KJ. Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest. 2007; 117(2): 289-296.
Tracey KJ. Understanding immunity requires more than immunology. Nature Immunology. 2010; 11(7): 561-564.
Vanneste S, De Ridder D. Brain Areas Controlling Heart Rate Variability in Tinnitus and Tinnitus-Related Distress. PloS ONE. 2013; 8(3): e59728.
Winkelmann T, Thayer JF, Pohlak ST, Nees F, Grimm O, Flor H. Structural brain correlates of heart rate variability in healthy young adult population. Brain Structure and Function. 2017; 222(2): 1061-1068.
Yoo HJ, Thayer JF, Greenig S, Lee TH,, Ponzio A, Min J, Sakaki M, Nga L, Mater M, Koenig J. Brain structural concomitants of resting state heart rate variability in the young and old: evidence from two independent samples. Brain Structure and Function. 2018; 223(2): 727-737.
Yushkovs’ka OG. Using information theory to study adaptive responses in the body athletes [in Ukrainian]. Medical Rehabilitation, Kurortology, Physiotherapy. 2001; 1(25): 40-43.
Zukow W, Popadynets’ OO, Gozhenko AI, Popovych IL. Interindividual differences in parameters of the EEG and HRV in the humans with various levels of the entropy of EEG, HRV, immunocytogram and leukocytogram. Journal of Education, Health and Sport. 2019; 9(7): 448-466.
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