Effect of chrysin on histomorphometrical parameters of bones in ovariectomized rats
DOI:
https://doi.org/10.12775/HERB.2017.003Keywords
osteoporosis, rats, ovariectomy, chrysin, phytoestrogens, histomorphometric parametersAbstract
Osteoporosis is a disease caused by many factors, for example by estrogens deficiency in menopausal women. It is characterized by decreased mechanical strength of the bones resulting from alterations in bone microarchitecture. To prevent postmenopausal osteoporosis development, hormonal replacement therapy can be used. There are however many side effects of such therapy, thus safe alternative is needed. Scientific reports indicate that plant -derived substances, including flavonoids, may be helpful in postmenopausal osteoporosis prevention or treatment. These substances are called ‘phytoestrogens’. The aim of the study
was to examine if chrysin – a plant-derived flavonoid – reveals protective effect on bone tissue microarchitecture in rats with experimental osteoporosis. The study was conducted on female Wistar rats divided into groups: SHAM – sham operated, OVX – ovariectomized rats and OVX+CHR – ovariectomized rats treated with chrysin at a dose of 50 mg/kg. Tested flavonoid was administered orally for 4 weeks. Obtained bones were weighted and measured, then histological specimens were prepared and histomorphometric parameters were analyzed. The results indicate, that chrysin administered to ovariectomized rats leads
to meager improvement of analyzed parameters.
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