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Pedagogy and Psychology of Sport

Acetazolamide in prevention of altitude disease
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Acetazolamide in prevention of altitude disease

Authors

  • Paweł Choroszewicz Scientific Circle of Exercise Physiology at Department of Hygiene, Epidemiology and Ergonomics. Division of Ergonomics and Exercise Physiology, Nicolaus Copernicus Univeristy in Toruń, Collegium Medicum in Bydgoszcz
  • Anna Maria Dobosiewicz Scientific Circle of Exercise Physiology at Department of Hygiene, Epidemiology and Ergonomics. Division of Ergonomics and Exercise Physiology, Nicolaus Copernicus Univeristy in Toruń, Collegium Medicum in Bydgoszcz
  • Nataliia Badiuk State Enterprise Ukrainian Research Institute for Medicine of Transport, Ministry of Health of Ukraine, Odesa https://orcid.org/0000-0002-8290-0605

DOI:

https://doi.org/10.12775/PPS.2020.06.02.009

Keywords

HAPE, HACE, AMS, acetazolamide

Abstract

Mountain climbing is associated with many risky, life-threatening situations. One of the most common attacking diseases at altitudes above 2500 m is altitude disease (HAI). This disease consists of: acute alpine disease, cerebral oedema and pulmonary oedema at altitude. The best way to prevent altitude diseases is by means of alcomatisation and slow increase in altitude. Climbers should follow the principle "climb high, sleep low". Sometimes, however, time or inability to descend do not allow for acclimatization. In such conditions, it is necessary to use pharmaceuticals that prevent the occurrence of an illness of altitude. The following article discusses research on the most commonly used drug in the prevention of acute mountain disease - acetazolamide. This drug was first used in the 60s of the XX century, demonstrating its effectiveness in the prevention of mountain disease. Since then, it has been the subject of many studies.

References

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Basnyat B., Gertsche JH., Johnson EW., Castro-Marin F., Inoue Y., Yeh Clement.: Efficacy of Low-Dose Acetazolamide (125 Mg BID) for the Prophylaxis of Acute Mountain Sickness: A Prospective, Double-Blind, Randomized, Placebo-Controlled Trial, High Alt Med Biol 2003; 4(1): 45-52.

Basnyat B., Hargove J., Holck PS., Srivastav S., Alekh K., Ghimire LV., Pandey K., Griffitsh A., Shankar R., Kaul K., Paudyal A., Stasiuk D., Basnyat R., Davis Ch., Southard A., Robinson C., Shandley T., Johnson DW., Zafren K., Williams S., Weiss EA., Farrar JJ., Swenson ER.: Acetazolamide fails to decrease pulmonary artery pressure at high altitude in partially acclimatized humans, High Alt Med Biol 2008; 9(3): 209-216.

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Schmickl ChN., Owens RL., Orr JE., Edwards BA., Malhotra A.: Side effects of acetazolamide: a systematic review and meta-analysis assessing overall risk and dose dependence, BMJ Open Respir Res 2020; 7(1): e000557.

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Tissot van Patot M., Leadbetter H., Keyes LE., Maakeastad KM., Olson S., Hackett HP.: Prophylactic low-dose acetazolamid reduces the incidence and severity of acute mountain sickness, High Alt Med Biol. 2008; 9(4): 289-293.

Wright AD., Brearey SP., Imray Che.: High Hopes at High Altitudes: Pharmacotherapy for Acute Mountain Sickness and High-Altitude Cerebral and Pulmonary Oedema, Expert Opin Pharmacother 2008; 9(1): 119-127.

Zawadzki A.: Medycyna ratunkowa i katastrof. Warszawa PZWL 2006, 123–125.

Pedagogy and Psychology of Sport

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Published

2020-05-29

How to Cite

1.
CHOROSZEWICZ, Paweł, DOBOSIEWICZ, Anna Maria and BADIUK, Nataliia. Acetazolamide in prevention of altitude disease. Pedagogy and Psychology of Sport. Online. 29 May 2020. Vol. 6, no. 2, pp. 95-103. [Accessed 4 July 2025]. DOI 10.12775/PPS.2020.06.02.009.
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Vol. 6 No. 2 (2020)

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Review Articles

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