The role of asthma’s basic therapy in the development of endothelial dysfunction in children

Veronika M. Dudnyk, Katerina V. Khromykh

DOI: http://dx.doi.org/10.12775/PPS.2015.01.02.004

Abstract


Purpose - estimation of basic anti-inflammatory therapy with inhaled glucocorticoids in the development of endothelial dysfunction in children with asthma. Materials and methods. Comprehensively examined 224 children with asthma, aged 6 - 17 years, with determination of homocysteine and vascular endothelial growth factor. 40 healthy children were examined as a control group. Results. Established that the likelihood of adverse effects when using the highest GCI monotherapy (OR 8,889; 95% CI 4,803 - 16,449) and combination therapy with mast cell membranes stabilizeres (OR 1,111; 95% CI1,051 - 2,734). Determined that the risk factors increase homocysteine than 17.36 (11.3 - 24.5) mmol / l and VEGF above 431.66 (238.04 - 658.09) pg / ml in serum of children with asthma were using of doses aerosol inhalators without conveying device and without increasing of IGC dose.


Keywords


asthma; children; endothelial dysfunction.

Full Text:

PDF

References


Tawakol, A., Omland, T., Gerhard, M. et al. Hyperhomocyst(e)inemia is associate with

impaired endothelium-dependant vasodilatation in humans. Circulation 1997; 95: 1119-21.

Simpson A., Custovic A., Tepper R., Graves P., Stern D. A. Jones M. et al. Genetic

Variation in Vascular Endothelial Growth Factor-A and Lung Function. Am. J Respir. Crit. Care

Med. 2012; 185(11); 1197–1204

Wanner A., Mendes E. S. Airway Endothelial Dysfunction in Asthma and Chronic

Obstructive Pulmonary Disease: A Challenge for Future Research . Am. J. of Respiratory and Crit.

Care Med. 2010; 182; 1344–1351.


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Refbacks

  • There are currently no refbacks.


The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. Zgodnie z Rozporządzeniem ministra nauki i szkolnictwa wyższego z dnia 22 lutego 2019 r. w sprawie ewaluacji jakości działalności naukowej (w szczególności art. 12 ust. 1 pkt 1 w zw. z art. 8 pkt 2), czasopismo Pedagogy and Psychology of Sport ewaluowane jest punktacją w wysokości 5 punktów. e-ISSN: 2450-6605 Numer DOI: 10.12775/PPS Indexing: Index Copernicus Master List https://journals.indexcopernicus.com/search/journal/issue?issueId=all&journalId=46499 DOAJ ERIH Plus Polska Bibliografia Naukowa PBN Akademicka Platforma Czasopism Naukowych Google Scholar BASE CrossRef WorldCat Arianta Baidu Scholar J-Gate JournalTOCs Microsoft Academic POL-index

Partnerzy platformy czasopism