The role of asthma’s basic therapy in the development of endothelial dysfunction in children
DOI:
https://doi.org/10.12775/PPS.2015.01.02.004Keywords
asthma, children, endothelial dysfunction.Abstract
Purpose - estimation of basic anti-inflammatory therapy with inhaled glucocorticoids in the development of endothelial dysfunction in children with asthma. Materials and methods. Comprehensively examined 224 children with asthma, aged 6 - 17 years, with determination of homocysteine and vascular endothelial growth factor. 40 healthy children were examined as a control group. Results. Established that the likelihood of adverse effects when using the highest GCI monotherapy (OR 8,889; 95% CI 4,803 - 16,449) and combination therapy with mast cell membranes stabilizeres (OR 1,111; 95% CI1,051 - 2,734). Determined that the risk factors increase homocysteine than 17.36 (11.3 - 24.5) mmol / l and VEGF above 431.66 (238.04 - 658.09) pg / ml in serum of children with asthma were using of doses aerosol inhalators without conveying device and without increasing of IGC dose.
References
Tawakol, A., Omland, T., Gerhard, M. et al. Hyperhomocyst(e)inemia is associate with
impaired endothelium-dependant vasodilatation in humans. Circulation 1997; 95: 1119-21.
Simpson A., Custovic A., Tepper R., Graves P., Stern D. A. Jones M. et al. Genetic
Variation in Vascular Endothelial Growth Factor-A and Lung Function. Am. J Respir. Crit. Care
Med. 2012; 185(11); 1197–1204
Wanner A., Mendes E. S. Airway Endothelial Dysfunction in Asthma and Chronic
Obstructive Pulmonary Disease: A Challenge for Future Research . Am. J. of Respiratory and Crit.
Care Med. 2010; 182; 1344–1351.
Downloads
Published
How to Cite
Issue
Section
License
The periodical offers access to content in the Open Access system under the Creative Commons non-exclusive license (CC BY-ND 4.0).Stats
Number of views and downloads: 217
Number of citations: 0
