Critical insights into the genomics-guided Nanomedicine for Rare Alport Syndrome Variants: Disruption of Collagen IV in Alport syndrome

Abstract

The disruption of collagen IV plays a central role in pathogenesis of Alport syndrome which involves multiple aspects including genomics guided nanomedicine for rare Alport variants which are not widely explored. The existing articles provides insights on cell-based factors but the challenges regarding transport of therapies to the glomerular basement membrane still remains a major issue. Not only this but there is a lack of variant specific approach in the aforementioned articles. This critical insight aims to overcome the current translational barriers and advance personalized therapy for almost syndrome.